NCMRR-DC Core Molecular & Functional Outcome Measures in Rehabilitation Medicine

NCMRR-DC核心分子

• 批准号: 8675744
• 负责人: SUSAN M KNOBLACH
• 金额: $ 94.99万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8675744
• 关键词: Adult; Age; Ancillary Study; Appointment; Award; Back; Bioinformatics; Biological Markers; Brain; Cerebral Palsy; Charge; Child; Clinical; Communities; Computer software; Data; District of Columbia; Educational workshop; Ensure; Environment; Equipment; Evaluation; Faculty; Feedback; Functional disorder; Funding; Funding Applicant; Genes; Genetic; Genomics; Genotype; Goals; Health Sciences; Healthcare Systems; Housing; Human; Human Resources; Institution; International; Investments; Limb structure; Medical; Medical center; Medicine; Messenger RNA; Methods; MicroRNAs; Modeling; Molecular; Monitor; Mus; Occupational; Outcome; Outcome Measure; Outcomes Research; Patients; Pharmaceutical Preparations; Phenotype; Physical Medicine; Pilot Projects; Preclinical Drug Evaluation; Premature Infant; Principal Investigator; Procedures; Process; Proteins; Proteome; Proteomics; Quality of life; Reagent; Rehabilitation Research; Rehabilitation therapy; Research; Research Personnel; Resources; Sampling; Services; Site; Software Tools; Spinal Cord; Spinal Dysraphism; Surveys; Systems Biology; Technology; Testing; Training; Trauma; United States National Institutes of Health; Universities; Washington; Writing; cohort; cost; design; disability; functional outcomes; genome wide association study; improved; lectures; medical schools; meetings; neuromuscular; new technology; outreach; pre-clinical; programs; protein protein interaction; public health relevance; respiratory; success; symposium

DESCRIPTION (provided by applicant): Medical rehabilitation is a research and clinical concern across the age span. Premature infants require rehabilitation of multiple types (physical, respiratory, occupational), children with cerebral palsy and spina bifida have extensive rehabilitation needs. Adults with spinal cord, brain, and limb trauma all require extensive rehabilitation support. Research to improve functional outcomes, and understand the pathophysiology of specific disabilities is important, both for patient quality of life, as well as burden on the health care system. The goal of our NCMRR-DC Core is to provide technical services and training across both molecular and functional outcome measures in rehabilitation research. During the previous award period, our NCMRR Core provided services and training to 108 principal investigators in 32 institutions, with processing and analysis of >4,500 samples. Didactic and outreach efforts included >3,500 hrs of on-site training of external investigators, 95 invited lectures, 29 presentations at national and international conferences, and organization of workshops to write and disseminate standard operating procedures for functional outcome measures. In this competitive renewal application, the PIs have extended their molecular outcomes services and training to include murine and human functional outcomes. These include clinical evaluator services and training, a murine functional testing facility, and facilitation of ancillary studies in pre-existing human cohorts emphasizing functional outcomes. These new resources have been established over the last 4 years, have been heavily utilized by the international rehabilitation research community, and are now proposed as a part of the NCMRR-DC Core.

描述（由申请人提供）：医疗康复是一个跨年龄段的研究和临床问题。早产儿需要多种类型的康复（身体，呼吸，职业），脑瘫和脊柱裂儿童有广泛的康复需求。患有脊髓、脑和肢体创伤的成年人都需要广泛的康复支持。研究以改善功能结果，并了解特定残疾的病理生理学是很重要的，无论是病人的生活质量，以及对医疗保健系统的负担。我们的NCMRR-DC核心的目标是在康复研究中提供分子和功能结果测量的技术服务和培训。在上一个授予期间，我们的NCMRR核心为32个机构的108名主要研究者提供了服务和培训，处理和分析了超过4，500个样本。教学和外联工作包括对外部调查人员进行超过3 500小时的现场培训，95次特邀讲座，在国家和国际会议上作29次演讲，并组织讲习班编写和传播功能成果措施的标准作业程序。在这项竞争性更新申请中，PI已将其分子结果服务和培训扩展到包括小鼠和人类功能结果。这些措施包括临床评价服务和培训，鼠功能测试设施，并促进辅助研究，在预先存在的人类队列强调功能的结果。这些新资源是在过去4年中建立的，已被国际康复研究界大量利用，现在被提议作为NCMRR-DC核心的一部分。

项目成果

Directional secretomes reflect polarity-specific functions in an in vitro model of human bronchial epithelium.

• DOI: 10.1165/rcmb.2013-0188oc
• 发表时间: 2013-09
• 期刊: American journal of respiratory cell and molecular biology
• 影响因子: 6.4
• 作者: D. Pillai;Binu-John Sankoorikal;Eric Johnson;A. N. Seneviratne;Jessica Zurko;K. Brown;Y. Hathout;M. Rose

GeneShelf: a web-based visual interface for large gene expression time-series data repositories.

GeneShelf：一​​个基于网络的大型基因表达时间序列数据存储库的可视化界面。

• DOI: 10.1109/tvcg.2009.146
• 发表时间: 2009
• 期刊: IEEE transactions on visualization and computer graphics
• 影响因子: 5.2
• 作者: Kim,Bohyoung;Lee,Bongshin;Knoblach,Susan;Hoffman,Eric;Seo,Jinwook
• 通讯作者: Seo,Jinwook

Clinical outcome measures for trials in Duchenne muscular dystrophy: report from International Working Group meetings.

• DOI: 10.4155/cli.11.113
• 发表时间: 2011-09
• 期刊: Clinical investigation
• 作者: Bushby K;Connor E
• 通讯作者: Connor E

CK-MM Polymorphism is Associated With Physical Fitness Test Scores in Military Recruits.

CK-MM 多态性与新兵体能测试分数相关。

• DOI: 10.7205/milmed-d-14-00331
• 发表时间: 2015
• 期刊: Military medicine
• 影响因子: 1.2
• 作者: Sprouse,Courtney;Tosi,LauraL;Gordish-Dressman,Heather;Abdel-Ghani,MaiS;Panchapakesan,Karuna;Niederberger,Brenda;Devaney,JosephM;Kelly,KarenR
• 通讯作者: Kelly,KarenR

HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs).

• DOI: 10.18632/oncotarget.13807
• 发表时间: 2017-01-10
• 期刊: Oncotarget
• 作者: Paget S;Dubuissez M;Dehennaut V;Nassour J;Harmon BT;Spruyt N;Loison I;Abbadie C;Rood BR;Leprince D
• 通讯作者: Leprince D