Interdepartmental Neuroscience Center

跨部门神经科学中心

• 批准号: 8771878
• 负责人: XANDRA OWENS BREAKEFIELD
• 金额: $ 80.18万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8771878
• 关键词: Area; Brain Neoplasms; Cancer Grant Supplements (P30); Collaborations; Core Facility; Development; Diagnosis; Drug Addiction; Equipment; Evaluation; Faculty; Fostering; Funding; General Hospitals; Goals; Growth; Guidelines; Image Analysis; Individual; Laboratories; Massachusetts; Microscopy; Movement Disorders; National Institute of Neurological Disorders and Stroke; Neurodegenerative Disorders; Neurosciences; Neurosciences Research; Pain; Production; Research; Research Personnel; Research Support; Resources; Services; Surveys; Wages; base; design; gene therapy; interest; nervous system disorder; new technology; nucleic acid quantitation; programs; response; spinal cord and brain injury; tool development; viral vector development

The goal of this application is to renew Core facilities to support neuroscience research at the Massachusetts General Hospital (MGH). The MGH Interdepartmental Neuroscience Center consists of about 50 faculty with shared interests in basic and applied neuroscience. The focus of the research is on high-impact, national priority areas such as neurodegenerative diseases, developmental neurological disorders, movement disorders, traumatic/ischemic brain and spinal cord injury, brain tumors, pain, drug addiction, gene therapy and basic neuroscience. The research base at the Center has grown enormously since the Center's inception in 1988. The growth is accompanied by an equally strong and rapid increase in demand for shared equipment and facilities. In response to this critical shortage, the Center's investigators have raised institutional and external funding to develop some core services. In 2003, with help from the NINDS P30 award a new core facilities program was established. This program has become extremely valuable for sustaining neuroscience research, especially that of new investigators and for fostering new collaborations. The present application seeks to renew support for this core facilities program. We conducted detailed surveys of the needs of NINDS-funded laboratories and evaluated utilization of the existing core resources. Based on the results of the surveys and evaluations, we seek support to renew and enhance the following cores: A) Microscopy and image analysis, B) Nucleic acid quantitation and C) Viral vector development and production. An administrative core to support the program is also proposed. The cores will serve the needs of 90 NINDS funded projects and also non-NINDS funded projects as per program guidelines. The Cores are designed to support ongoing research, especially of our junior faculty, and to stimulate development of novel technology and research by a) offering service, equipment and expertise not available in individual laboratories and b) fostering synergistic interactions among the investigators. A detailed plan for efficient and equitable dispensation of services is proposed. The Cores have received institutional commitment of funds for equipment, salary and space and do not duplicate existing shared facilities.

该应用程序的目标是更新核心设施，以支持马萨诸塞州总医院 (MGH) 的神经科学研究。 MGH 跨部门神经科学中心由约 50 名对基础和应用神经科学有着共同兴趣的教员组成。研究重点是高影响力的国家优先领域，如神经退行性疾病、发育性神经障碍、运动障碍、创伤/缺血性脑和脊髓损伤、脑肿瘤、疼痛、药物成瘾、基因治疗和基础神经科学。自 1988 年成立以来，该中心的研究基础得到了巨大的发展。这种发展伴随着对共享设备和设施的需求同样强劲和快速的增长。为了应对这一严重短缺，该中心的研究人员筹集了机构和外部资金来开发一些核心服务。 2003 年，在 NINDS P30 奖项的帮助下，建立了一个新的核心设施计划。该计划对于维持神经科学研究，特别是新研究人员的研究和促进新的合作变得极其有价值。本申请旨在继续支持这一核心设施计划。我们对NINDS资助的实验室的需求进行了详细调查，并对现有核心资源的利用情况进行了评估。根据调查和评估的结果，我们寻求支持来更新和增强以下核心：A）显微镜和图像分析，B）核酸定量和C）病毒载体开发和生产。还提出了支持该计划的行政核心。根据计划指南，这些核心将满足 90 个 NINDS 资助项目以及非 NINDS 资助项目的需求。核心旨在支持正在进行的研究，特别是我们的初级教师的研究，并通过以下方式刺激新技术和研究的发展：a）提供单个实验室所不具备的服务、设备和专业知识；b）促进研究人员之间的协同互动。提出了有效和公平分配服务的详细计划。核心项目已获得机构承诺的设备、工资和空间资金，并且不会重复现有的共享设施。