DHA Supplementation and Pregnancy Outcome

DHA 补充和怀孕结果

• 批准号: 8609043
• 负责人: SUSAN E CARLSON
• 金额: $ 46.89万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-04 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8609043
• 关键词: 6 year old; Achievement; Adaptive Behaviors; Address; Adult; Affect; Age; Age-Months; Aging; Attention; Attention deficit hyperactivity disorder; Behavior; Belief; Biological; Birth; Child; Child Development; Child health care; Childhood; Clinical Trials; Cognition; Cognitive; Data; Data Collection; Development; Dietary intake; Docosahexaenoic Acids; Double-Blind Method; Drug Formulations; Enrollment; Environment; Event; Fatty Acid Desaturases; Goals; Health; Human; Individual; Infant; Informal Social Control; Intake; Intelligence; Investments; Language; Language Development; Learning; Length; Life; Link; Literature; Measures; Memory; Mental Depression; Nursery Schools; Nutritional; Observational Study; Outcome; Outcome Study; Parents; Performance; Personal Satisfaction; Phase; Physiological; Placebos; Play; Policies; Pregnancy; Pregnancy Outcome; Pregnant Women; Prenatal Nutrition; Prevalence; Problem behavior; Process; Psychopathology; Psychophysiology; Public Policy; Randomized Clinical Trials; Readiness; Reading; Records; Regulation; Reporting; Role; Sampling; Schedule; School-Age Population; Schools; Single Nucleotide Polymorphism; Social Welfare; Supplementation; Testing; Ursidae Family; Visual Acuity; Visual attention; Woman; base; cognitive function; cohort; evidence base; executive function; fetal programming; follow-up; frontal lobe; language processing; literacy; nutrition; offspring; postnatal; prenatal; skills; success

DESCRIPTION (provided by applicant): This application seeks to renew project R01 HD047315, which supported the conduct of a randomized clinical trial of a high level of supplementation of docosahexaenoic acid (DHA) during the prenatal period (ClinicalTrials.gov ID: NCT00266825). We achieved the enrollment and follow-up goals of the original RCT and, most importantly for the current proposal, we have retained the planned large cohort of children born to women enrolled in the parent trial. Infants enrolled and followed to 18 months of age in this trial are now entering a particularly important period of cognitive and intellectual development, and the successful retention of the current sample allows for an unprecedented opportunity to determine if prenatal supplementation of DHA affects preschool and school-age outcomes that predict successful school performance and adaptive behaviors. The different skills that emerge at these ages build on early components of cognition, which have been positively associated with higher DHA status in both observational studies and clinical trials. We propose to test these infants on a semi-annual basis from 24 through 72 months of age employing outcomes that assess four domains of development that are critical to health, adjustment, and well-being through adulthood: (a) higher-order cognition (memory, attention, and executive function), (b) language processing and preliteracy skills, (c) adaptive regulation (self-regulation skills related to behavioral problems, school performance, and child psychopathology), and (d) intelligence. The proposed assessments will allow us to determine whether prenatal nutritional supplementation with DHA affects child health and development. The findings could contribute to evidence-based policy on prenatal nutrition. In addition, the evidence from this renewal would address hypotheses concerning fetal programming and human behavior that are currently at the forefront within the field of health, development and nutrition.

描述（由申请人提供）：本申请寻求更新R01 HD047315项目，该项目支持在产前期间进行高水平补充二十二碳六烯酸（DHA）的随机临床试验（ClinicalTrials.gov ID: NCT00266825）。我们达到了最初的随机对照试验的入组和随访目标，最重要的是，我们保留了在父母试验中登记的妇女所生的孩子的计划大队列。在这项试验中招募并随访到18个月大的婴儿，现在正进入认知和智力发展的一个特别重要的时期，当前样本的成功保留为确定产前补充DHA是否影响学前和学龄阶段的结果提供了前所未有的机会，这些结果可以预测成功的学业表现和适应行为。在这些年龄段出现的不同技能建立在早期认知的基础上，在观察性研究和临床试验中，这与较高的DHA水平呈正相关。我们建议每半年对这些婴儿进行一次测试，从24个月到72个月，采用评估四个发展领域的结果，这些领域对成年后的健康、适应和福祉至关重要：(a)高阶认知（记忆、注意力和执行功能），(b)语言处理和识字前技能，(c)适应性调节（与行为问题、学校表现和儿童精神病理学相关的自我调节技能），以及(d)智力。拟议的评估将使我们能够确定产前补充DHA是否会影响儿童的健康和发育。这些发现可能有助于制定以证据为基础的产前营养政策。此外，这一更新的证据将解决目前在健康、发育和营养领域处于前沿的关于胎儿计划和人类行为的假设。