Aging Aminal & Longevity Assessment Core

老龄化动物和寿命评估核心的目的是为中心调查人员和 研究人员在大学外衰老时拥有广谱的统一维护，无特定病原体 用于研究衰老的啮齿动物模型，根据它们的需要。核心将继续发挥核心作用 在内森休克衰老中心。核心中心的所有动物都将得到NIA或其他老龄补助金的支持。这个 CORE将繁殖、维护和监测老化的啮齿动物群体，确定它们的寿命和与年龄相关的 改变体重、身体成分和食物摄入量，并将这些动物分发给中心成员和 其他用于衰老的基础研究。此外，在试点研究中，核心将维持两个人的小群体 中心研究人员最近发现的小鼠模型具有非凡的理解潜力 衰老的基本机制：1)雷帕霉素处理的遗传异种小鼠和2)两组 重组近交系小鼠品系对卡路里限制反应的极端分布 (CR)？一组菌株对CR表现出特征的寿命延长，而另一组 会导致寿命缩短的菌株。这些以及由该核心实现的其他改进强调了其 作为生物老年学发现的推动者的重要性。核心计划的具体目标如下： 1培育和维护新的和已建立的啮齿动物模型，用于研究衰老和/或 与年龄相关的疾病过程。 对基因、营养或药物操纵的模型进行寿命研究 满足由NIA和其他赠款来源资助的调查人员的要求。 为基线先导研究提供具有特殊生物老年学意义的动物模型。 向广大生物老年病学界提供含有雷帕霉素和其他药物的饮食。 教育和建议教师、研究员和对老龄化感兴趣的学生关于以下方面的特殊要求 老龄化研究中的畜牧业。

The purpose of the Aging Animal and Longevity Assessment Core is to provide Center investigators and researchers in aging outside the University with a broad spectrum of uniformly maintained, specific-pathogen free rodent models for the study of aging, according to their needs. The Core will continue to play a central role in the Nathan Shock Aging Center. All animals in the Core will be supported by NIA or other aging grants. The Core will breed, maintain and monitor aging rodent colonies, determine their longevity and age-related changes in weight, body composition and food intake, and distribute these animals to Center members and others for basic research on aging. In addition, the Core will maintain for pilot studies small populations of two murine models that Center investigators have recently found to have exceptional potential for understanding fundamental mechanisms of aging: 1) rapamycin-treated genetically heterogeneous mice and 2) two groups of recombinant inbred mouse strains at the extremes of the distribution of strain responses to calorie restriction (CR) ¿ one group of strains that shows characteristic life extension in response to CR and the other group of strains that responds with life shortening. These and other advances enabled by this Core underscore its importance as a generator of biogerontologic discovery. The Specific Aims of the Core are as follows: 1 To breed and maintain new and established rodent models for study of the mechanism of aging and/or age-related disease processes. To conduct lifespan studies of genetically, nutritionally, or pharmacologically manipulated models according to the requirements of investigators funded by the NIA and other granting sources. To provide animal models of exceptional biogerontological interest for baseline pilot studies. To provide diets containing rapamycin and other drugs to the biogerontological community at large. To educate and advise faculty, fellows, and students interested in aging on the special requirements of animal husbandry in aging research.