Investigating the role of the NR4A nuclear receptor family in melanocyte function and tumorigenesis

研究 NR4A 核受体家族在黑素细胞功能和肿瘤发生中的作用

• 批准号: nhmrc : 631510
• 负责人: A/Pr Richard Sturm
• 金额: $ 37.03万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-role-nr4a-function-tumorigenesis/98412
• 关键词: Investigating; role; NR4A; nuclear; receptor

Individuals with red hair and fair skin have a considerably greater risk of developing melanoma and non-melanoma skin cancer. Understanding the relationship that genes such as MC1R and NR4As have to skin functions such as tanning and protection from UV damage, will provide a greater insight into melanoma susceptibility and progression. Furthermore, understanding the role that abnormal NR4A regulation plays in melanoma formation will aid in the identification of new therapeutic targets.

红头发和白皙皮肤的人患黑色素瘤和非黑色素瘤皮肤癌的风险要大得多。了解MC1R和NR4A等基因与皮肤功能（如晒黑和保护免受紫外线损伤）的关系，将为黑色素瘤易感性和进展提供更深入的了解。此外，了解异常NR4A调节在黑色素瘤形成中的作用将有助于识别新的治疗靶点。