Ligand interactions of the MC1R receptor and cellular consequences for melanocyte responses to UV-damage

MC1R 受体的配体相互作用以及黑素细胞对紫外线损伤反应的细胞后果

• 批准号: nhmrc : 1023884
• 负责人: A/Pr Richard Sturm
• 金额: $ 38.56万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/ligand-interactions-mc1r-uv-damage/110306
• 关键词: Ligand; interactions; MC1R; receptor; cellular

Although it is evident that fair skin types are more susceptible to sun damage, the relationship between sun exposure, skin colour and skin cancer formation is less clear. The genes and processes that determine an individual's skin phototype and the mechanisms involved in the tanning response after UV-exposure of the skin are the focus of this investigation. A major regulator of the response to UV radiation in the skin is the melanocortin-1 receptor. It is essential to understand the complex interactions of this receptor that induce tanning.

虽然很明显，白皙的皮肤类型更容易受到阳光的伤害，但阳光照射，肤色和皮肤癌形成之间的关系尚不清楚。决定个人皮肤光型的基因和过程，以及紫外线暴露后皮肤晒黑反应的机制是这项调查的重点。皮肤中对UV辐射的反应的主要调节剂是黑皮质素-1受体。了解这种受体诱导晒黑的复杂相互作用至关重要。