Investigating the role of pigmentation pathway genes in moliness and melanoma risk

研究色素沉着途径基因在色素性和黑色素瘤风险中的作用

• 批准号: nhmrc : 552485
• 负责人: A/Pr Richard Sturm
• 金额: $ 62.92万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-role-pigmentation-melanoma-risk/100485
• 关键词: Investigating; role; pigmentation; pathway; genes

Melanoma is an important cause of death in Australia and our generally light pigmentation in a geographical area of high sun exposure is a major factor in this. Our research increasingly points to certain pigmentation genes having a direct biochemical influence on cancer risk in addition to their risk via pigmentation. Understanding how the genes that deternine skin, hair and eye colour act to modify moliness and melanoma risk is important for public health prevention schemes.

黑色素瘤是澳大利亚死亡的一个重要原因，而我们在高日照地理区域的色素沉着通常较浅，这是一个主要因素。我们的研究越来越多地指出，某些色素沉着基因除了通过色素沉着产生风险外，还对癌症风险产生直接的生化影响。了解决定皮肤、头发和眼睛颜色的基因是如何改变患上黄褐斑和黑色素瘤的风险的，对公共卫生预防计划很重要。