The Seventh International Mdm2 Workshop

第七届国际Mdm2研讨会

• 批准号: 8597241
• 负责人: James J Manfredi
• 金额: $ 0.4万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8597241
• 关键词: Address; Area; Award; Binding; Biochemical; Biological; Biology; Cancer Center; Collaborations; Complement; Doctor of Medicine; Doctor of Philosophy; Educational workshop; Embryonic Development; Ensure; Event; Funding; Gene Amplification; Goals; Human; Individual; Institutes; International; Knowledge; Malignant Neoplasms; Mentors; Minority; Missense Mutation; Molecular; Oncogene Proteins; Pathway interactions; Philadelphia; Play; Postdoctoral Fellow; Protein p53; Reagent; Recruitment Activity; Reporting; Research; Research Personnel; Role; Scientist; Senior Scientist; Site; Staging; Students; TP53 gene; Time; Translating; Travel; Tumor Suppressor Proteins; Underrepresented Minority; United Kingdom; Universities; Woman; Writing; abstracting; career; graduate student; human disease; in vivo; meetings; member; mouse model; overexpression; posters; public health relevance; role model; social; symposium; tumor; ubiquitin-protein ligase

DESCRIPTION (provided by applicant): The p53 protein has been well-characterized as playing a tumor suppressor role in human cancer. Indeed, a majority of human tumors have sustained missense mutation in the TP53 gene. Mdm2 is a negative regulator of p53 that has been shown to act by inhibiting the transcriptional activity of p53 via direct binding as well as serving as an E3 ubiquitin ligase to target p53 for degradation. Consistent with such findings, Mdm2 has been implicated as also playing a role in human tumors with its overexpression or gene amplification being observed in a variety of cancers. A p53 Workshop is held every two years to bring together the p53 field in order to report on the latest research and to facilitate collaboration and exchange of reagents. In 2010, the 15th International p53 Workshop was held in Philadelphia, PA. Twelve years ago, a complementing Mdm2 Workshop was organized to be held in alternating years with the p53 conference. The seventh such workshop is to be held in Cambridge, UK in August, 2013. The meeting is being co-organized by Drs. Karen Vousden (Beatson Institute) and Alan Fersht (University of Cambridge). The site of the conference is at the University of Cambridge in the United Kingdom. In this application, funds are being requested to support three important specific aims. The first aim is to facilitate the attendance o graduate students and postdoctoral researchers at the Sixth International Mdm2 Workshop and enhance their ability to interact with leaders in the field. The second aim is to ensure the attendance and participation of women and underrepresented minorities as invited speakers at the Workshop. This will be accomplished by the participation of two invited speakers who are both women and underrepresented minorities. The third aim is to enhance the attendance and participation of graduate students, postdoctoral researchers, and early-stage investigators who are from underrepresented groups including women and minorities. The goals of the three aims will largely be accomplished through the judicious use of travel awards. The International Mdm2 Workshop continues to be a unique venue in which researchers in the field of Mdm2 research can come together to share recent findings, facilitate collaborations, and enhance exchange of reagents. This stimulates scientific research by ensuring that Mdm2 investigators are aware of the most current research in this significant area. In so doing, duplicate efforts can be avoided, pitfalls can be shared, and knowledge in the field can move forward as rapidly as possible.

描述（由申请人提供）：p53蛋白在人类癌症中扮演肿瘤抑制作用。实际上，大多数人类肿瘤在TP53基因中持续了错义突变。 MDM2是p53的负调节剂，已显示通过通过直接结合抑制p53的转录活性以及用作E3泛素连接酶来靶向p53进行降解来起作用。与此类发现一致，MDM2也被牵涉到在人类肿瘤中发挥作用，其过表达或在各种癌症中都观察到了基因扩增。每两年举行一次p53研讨会，以将p53领域汇总在一起，以报告最新研究并促进试剂的协作和交换。 2010年，第15届国际P53研讨会于宾夕法尼亚州费城举行。十二年前，组织了一个补充的MDM2研讨会，该研讨会在P53会议上交替举行。第七届此类研讨会将于2013年8月在英国剑桥举行。会议由DRS共同组织。卡伦·沃斯登（Beatson Institute）和艾伦·弗斯特（Alan Fersht）（剑桥大学）。会议的地点位于英国剑桥大学。在此应用程序中，要求资金支持三个重要的特定目标。第六个国际MDM2研讨会的研究生和博士后研究人员的出勤率是促进出勤率，并增强了他们与该领域领导者互动的能力。第二个目的是确保妇女和人数不足的少数民族的出席和参与，作为讲习班的演讲者。这将通过两位受邀演讲者的参与来实现，这些演讲者既是妇女又是代表性不足的少数群体。第三个目的是提高研究生，博士后研究人员和早期研究人员的出勤和参与，这些研究人员来自包括妇女和少数群体在内的代表性不足的团体。这三个目标的目标将在很大程度上通过明智地使用旅行奖来实现。国际MDM2研讨会仍然是一个独特的场所，在该场所中，MDM2研究领域的研究人员可以共同分享最新发现，促进合作并增强试剂的交换。这是通过确保MDM2研究人员意识到这一重要领域最新研究的刺激科学研究。通过这样做，可以避免重复的努力，可以共享陷阱，并且该领域的知识可以尽快前进。