NIAMS Multidisciplinary Clinical Research Center

描述（申请人提供）：西北大学（NU）多学科临床研究中心（MCRC）的目标是：1）进行旨在预防或控制风湿性疾病和与这些疾病相关的不良结局的前沿研究; 2）提供学术环境，a）支持MCRC研究人员的多学科研究，和B）组织和激励风湿性疾病的研究在NU。目前在NU的MCRC作为一个综合单位运作，以解决广泛的临床研究工作。MCRC继续联合NU Feinberg医学院的医学系，预防医学系和医疗保健研究所，以及NU临床和转化科学研究所（NUCATS，NU的CTSA实体）。我们的MCRC的拟议新周期说明了这些关系的力量和新的合作发展与医学社会科学系和NU假肢和矫形中心。正如这个应用程序将显示，我们有一个优秀的，组织良好的研究基地，以及我们纳入和利用独特的机构资源。反过来，我们的中心继续通过为我们的机构开发新资源来丰富环境。 拟议的NU MCRC新周期包括一个管理核心，一个方法/数据管理核心和3个项目：项目1：身体活动变化和保留：膝关节OA的生活质量和结局;项目2：定义治疗目标以延迟膝关节OA的关节丢失和不良结局;项目3：评估队列研究中检测风湿性关节炎病例的算法。 该提案的具体目标是：确保这2个核心和4个项目的资金;利用MCRC资金进一步加强NU的风湿病研究;并参与国家努力，以提高学术界和广大社区对风湿性疾病的公共卫生负担和可能的公共卫生，医疗，和康复的解决方案，这些条件及其后果。我们有能力完成我们提出的工作，并继续作为一个组织和科学的重点，以激励风湿病研究在NU。

DESCRIPTION (provided by applicant): The goals of the Northwestern University (NU) Multidisciplinary Clinical Research Center (MCRC) are to: 1) conduct cutting-edge research aimed at the prevention or control of rheumatic diseases and poor outcomes associated with these conditions; 2) provide the academic environment that a) supports the multidisciplinary research of MCRC investigators, and b) organizes and galvanizes rheumatic disease research at NU. The current MCRC at NU operates as an integrated unit to address a broad range of clinical research endeavors. The MCRC continues to unite the NU Feinberg School of Medicine Division of Rheumatology in the Department of Medicine, the Department of Preventive Medicine, and the Institute for Healthcare Studies, as well as the NU Clinical and Translational Sciences Institute (NUCATS, NU's CTSA entity). The proposed new cycle of our MCRC illustrates the strength of these relationships and new collaboration development with the Department of Medical Social Sciences and the NU Prosthetics and Orthotics Center. As this application will show, we have an outstanding, well-organized research base as well as unique institutional resources that we incorporate and leverage. In turn, our Center continues to enrich the environment by developing new resources for our institution. The proposed new cycle of the NU MCRC includes an Administrative Core, a Methodology/Data Management Core, and 3 projects: Project 1: Physical Activity Changes & Thresholds: Quality of Life and Outcomes in Knee 0A; Project 2: Defining Targets for Therapy to Delay Cartilage Loss and Poor Outcome in Knee OA; Project 3: Evaluation of an Algorithm to Detect Rheumatoid Arthritis Cases in Cohort Studies. The specific objectives of this proposal are to: secure funding for these 2 Cores and 4 projects; to leverage this MCRC funding to further enhance rheumatic disease research at NU; and to participate in the national effort to increase awareness within the academic community and the community at large of the public health burden of the rheumatic diseases and the possible public health, medical, and rehabilitative solutions for these conditions and their consequences. We are strongly positioned to complete the work we propose and to continue to serve as an organizational and scientific focus to energize rheumatic disease research at NU.