Core Center for Clinical Research at Northwestern University

西北大学（NU）临床研究核心中心（CCCR）的总体目标 旨在促进旨在预防或控制风湿性和肌肉骨骼疾病的尖端临床研究， 条件和与之相关的不良结果。我们将提供广泛的支持， 寻求推动这一主题：预防战略和干预发展，以创造生活方式，行为， 医疗和康复方案。总体目标是：1）加速和加强资助的研究， 提高效率、严谨性、协作性、成本效益、生产力和影响力; 2）促进和增加 对所有与我们的使命相关的NU研究的价值;以及3）通过扩大社区来促进新的研究 在我们的使命领域开展工作，并在使命范围内扩大研究领域。该CCCR是 组织成管理、方法和资源核心。核心目标包括： 数据管理支持;与研究设计、研究实施、结局评估相关的专业知识，以及 数据分析;通过重点服务、协作和团队科学增强培训环境 培训;尖端能力，以满足研究社区在以下方面的持续和不断变化的需求： a）统计分析，B）流行病学，c）行为科学，d）营养科学，e）实施科学， f）经济评估，g）基因组学/生物信息学，和h）临床信息学。资源核心， 日常生活中的评估和干预科学与技术，将整合子核心（以人为本 结果评估和技术;身体活动、久坐行为的加速度计测量 和睡眠;和行为干预技术），这些目标：设计量身定制的多模式 评估和健康干预措施，纳入现实世界：a）自我报告的社会，身体和精神 健康、症状和生活满意度，以及运动、感觉和认知的基于表现的评估 功能; B）加速度测量以评估身体活动、久坐行为和睡眠;以及c）移动的，网络， 平板电脑和基于传感器的应用程序，这些应用程序使用GPS、活动日志和 可穿戴生物传感器，预测生理和心理状态;并实施技术平台 可以部署干预措施并管理多模式评估，整合到平台自我报告中， 基于性能和加速计评估。通过我们与预防医学的关系， 物理医学和康复，医学社会科学，物理治疗和人类运动 公共卫生和医学研究所以及NU临床和转化科学研究所 （CTSA）-这个CCCR将利用多元化的大学社区。反过来，我们的CCCR将创造强大的， 创新资源。因为这个CCCR a）以改善人们的感觉和功能为目标 在日常生活中，B）建立在可穿戴和便携式技术革命的基础上，以及c）集成 优秀的计划，它是有很好的定位，有实质性的影响内外我们的机构。

The overarching goal of the proposed Northwestern University (NU) Core Center for Clinical Research (CCCR) is to promote cutting-edge clinical research aimed at prevention or control of rheumatic and musculoskeletal conditions and poor outcomes associated with them. While we will provide broad support, we will particularly seek to drive this theme: prevention strategy and intervention development to create lifestyle, behavioral, medical, and rehabilitative solutions. Overall aims are: 1) accelerate and enhance funded research, by improving efficiency, rigor, collaboration, cost-effectiveness, productivity, and impact; 2) catalyze and add value to all NU research relevant to our mission; and 3) promote new research, by expanding the community working in the areas of our mission and by expanding research fields within the mission. This CCCR is organized into Administrative, Methodologic, and Resource Cores. Methodologic Core aims include, to provide: data management support; expertise pertaining to research design, study conduct, outcome assessment, and data analysis; an enhanced training environment through focused services, collaboration, team science training; cutting-edge capabilities to meet ongoing and evolving needs of the Research Community regarding: a) statistical analysis, b) epidemiology, c) behavioral science, d) nutritional science, e) implementation science, f) economic evaluation, g) genomics/bioinformatics, and h) clinical informatics. The Resource Core, Assessment & Intervention Science & Technology in Daily Life, will integrate Sub-Cores (Person-Centered Outcomes Assessment and Technology; Accelerometer Measurement of Physical Activity, Sedentary Behavior and Sleep; and Behavioral Intervention Technologies), with these aims: design tailored multi-modal assessment and health interventions, incorporating real-world: a) self-report of social, physical, and mental health, symptoms, and life satisfaction, and performance-based assessment of motor, sensory, and cognitive function; b) accelerometry to assess physical activity, sedentary behavior, and sleep; and c) mobile, web, tablet, and sensor-based applications that identify real-world behavioral markers using GPS, activity logs, and wearable biosensors, to predict physiological and psychological states; and implement technology platforms that can deploy interventions and administer multi-modal assessment, integrating into the platform self-report, performance-based, and accelerometer assessment. Through our relationships – with Preventive Medicine, Physical Medicine and Rehabilitation, Medical Social Sciences, Physical Therapy and Human Movement Sciences, the Institute for Public Health and Medicine, and the NU Clinical and Translational Sciences Institute (CTSA) – this CCCR will draw on a diverse university community. In turn, our CCCR will create powerful and innovative resources. Because this CCCR a) is centered on the goal to improve how persons feel and function in their daily lives, b) builds upon the wearable and portable technology revolution, and c) integrates outstanding programs, it is well-positioned to have substantial impact within and beyond our institution.