Core Center for Clinical Research at Northwestern University

西北大学临床研究核心中心

• 批准号: 9755201
• 负责人: Leena Sharma
• 金额: $ 75.83万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-19 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9755201
• 关键词: Accelerometer; Area; Behavior Therapy; Behavioral; Behavioral Sciences; Bioinformatics; Biosensor; Clinical Informatics; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Consultations; Custom; Data; Data Analyses; Data Collection; Development; Discipline; Educational process of instructing; Educational workshop; Ensure; Environment; Epidemiology; Evaluation; Faculty; Fostering; Funding; Genomics; Goals; Health; Human; Individual; Information Technology; Infrastructure; Institutes; Institution; Internet; Intervention; Kinesiology; Knowledge; Lead; Leadership; Life; Life Style; Measurement; Medical; Medicine; Mental Health; Mentors; Methodology; Methods; Mission; Monitor; Motor; Musculoskeletal; Nutritional Science; Operations Research; Outcome; Outcome Assessment; Patient Self-Report; Performance; Persons; Physical Medicine; Physical Rehabilitation; Physical activity; Physical therapy; Physiological; Positioning Attribute; Prevention; Prevention strategy; Preventive Intervention; Preventive Medicine; Productivity; Public Health; Rehabilitation therapy; Reporting; Research; Research Design; Research Personnel; Resource Sharing; Resources; Risk; Role; Science; Scientist; Sensory; Services; Sleep; Social Sciences; Statistical Data Interpretation; Structure; Symptoms; Tablets; Target Populations; Technology; Training; Translational Research; Universities; Vision; Work; base; cognitive function; cost effectiveness; data management; data sharing; design; economic evaluation; empowered; implementation science; improved; innovation; instrument; member; multimodality; operation; person centered; physical conditioning; portability; programs; prospective; psychologic; satisfaction; sedentary lifestyle; sensor; social; synergism; technological innovation; therapy development

The overarching goal of the proposed Northwestern University (NU) Core Center for Clinical Research (CCCR) is to promote cutting-edge clinical research aimed at prevention or control of rheumatic and musculoskeletal conditions and poor outcomes associated with them. While we will provide broad support, we will particularly seek to drive this theme: prevention strategy and intervention development to create lifestyle, behavioral, medical, and rehabilitative solutions. Overall aims are: 1) accelerate and enhance funded research, by improving efficiency, rigor, collaboration, cost-effectiveness, productivity, and impact; 2) catalyze and add value to all NU research relevant to our mission; and 3) promote new research, by expanding the community working in the areas of our mission and by expanding research fields within the mission. This CCCR is organized into Administrative, Methodologic, and Resource Cores. Methodologic Core aims include, to provide: data management support; expertise pertaining to research design, study conduct, outcome assessment, and data analysis; an enhanced training environment through focused services, collaboration, team science training; cutting-edge capabilities to meet ongoing and evolving needs of the Research Community regarding: a) statistical analysis, b) epidemiology, c) behavioral science, d) nutritional science, e) implementation science, f) economic evaluation, g) genomics/bioinformatics, and h) clinical informatics. The Resource Core, Assessment & Intervention Science & Technology in Daily Life, will integrate Sub-Cores (Person-Centered Outcomes Assessment and Technology; Accelerometer Measurement of Physical Activity, Sedentary Behavior and Sleep; and Behavioral Intervention Technologies), with these aims: design tailored multi-modal assessment and health interventions, incorporating real-world: a) self-report of social, physical, and mental health, symptoms, and life satisfaction, and performance-based assessment of motor, sensory, and cognitive function; b) accelerometry to assess physical activity, sedentary behavior, and sleep; and c) mobile, web, tablet, and sensor-based applications that identify real-world behavioral markers using GPS, activity logs, and wearable biosensors, to predict physiological and psychological states; and implement technology platforms that can deploy interventions and administer multi-modal assessment, integrating into the platform self-report, performance-based, and accelerometer assessment. Through our relationships – with Preventive Medicine, Physical Medicine and Rehabilitation, Medical Social Sciences, Physical Therapy and Human Movement Sciences, the Institute for Public Health and Medicine, and the NU Clinical and Translational Sciences Institute (CTSA) – this CCCR will draw on a diverse university community. In turn, our CCCR will create powerful and innovative resources. Because this CCCR a) is centered on the goal to improve how persons feel and function in their daily lives, b) builds upon the wearable and portable technology revolution, and c) integrates outstanding programs, it is well-positioned to have substantial impact within and beyond our institution.

拟议的西北大学临床研究核心中心(CCCR)的总体目标 是促进旨在预防或控制风湿病和肌肉骨骼疾病的尖端临床研究 条件和与之相关的不良后果。虽然我们将提供广泛的支持，但我们将特别 寻求推动这一主题：预防战略和干预发展，以创造生活方式，行为， 医疗和康复解决方案。总体目标是：1)加快和加强资助的研究，通过 提高效率、严谨性、协作性、成本效益、工作效率和影响力；2)催化和增加 对所有与我们的使命相关的NU研究的价值；以及3)通过扩大社区来促进新的研究 在我们的任务领域开展工作，并在任务范围内扩大研究领域。本CCCR是 组织成管理、方法和资源核心。方法论的核心目标包括： 数据管理支持；与研究设计、研究实施、结果评估和 数据分析；通过重点服务、协作、团队科学改善培训环境 培训；满足研究界在以下方面的持续和不断变化的需求的前沿能力： A)统计分析，b)流行病学，c)行为科学，d)营养科学，e)实施科学， F)经济评估，g)基因组学/生物信息学，h)临床信息学。资源核心， 日常生活中的评估和干预科技，将整合子核(以人为中心 结果评估和技术.体力活动和久坐行为的加速度计测量 和睡眠；以及行为干预技术)，具有这些目标：设计定制的多模式 评估和健康干预，结合现实世界：a)社会、身体和精神自我报告 健康、症状和生活满意度，以及基于性能的运动、感觉和认知评估 功能；b)加速测量法，以评估体力活动、久坐行为和睡眠；以及c)移动、网络、 平板电脑和基于传感器的应用程序，使用GPS、活动日志和 可穿戴生物传感器，用于预测生理和心理状态；并实施技术平台 可以部署干预措施和管理多模式评估，整合到平台自我报告中， 基于性能和加速度计评估。通过我们的关系--与预防医学， 物理医学与康复、医学社会科学、物理治疗与人体运动 科学、公共卫生和医学研究所以及国立大学临床和翻译科学研究所 (CTSA)-这项CCCR将利用多样化的大学社区。反过来，我们的CCCR将创造出强大的 创新资源。因为这个cccr a)以改善人们的感觉和功能为目标。 在日常生活中，b)建立在可穿戴和便携式技术革命的基础上，c)集成 作为优秀的项目，它处于有利地位，将在我们机构内外产生重大影响。