RBL-Innate Immunity Core

RBL-先天免疫核心

• 批准号: 8446490
• 负责人: DEBORAH M ANDERSON
• 金额: $ 9.84万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8446490
• 关键词: Achievement; Cell Separation; Containment; Development; Distant; Education; Emerging Communicable Diseases; Funding; Future; Goals; Growth; Immune response; Immunologic Techniques; Infection; Infectious Diseases Research; Institution; Investigation; Laboratories; Life; Mission; Missouri; National Institute of Allergy and Infectious Disease; Natural Immunity; Organism; Research; Research Activity; Research Personnel; Research Priority; Research Project Grants; Research Support; Resources; Sampling; Services; Therapeutic; Training; Universities; User Compliance; Washington; biodefense; combat; engineering design; flexibility; frontier; novel; pathogen; research and development

In 2002, the Blue Ribbon Panel established the research priorities for biodefense, including the prioritization of pathogens and the development of broad spectrum therapeutics to combat infections. This included two central themes: 1) the development of research capacity for organisms requiring high containment laboratories and 2) the centralization of research focus in the ten federally designated regions. In Region VII Washington University directs the Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research (MRCE). Laboratory expansion in region VII occurred at the University of Missouri and the NIAID Regional Biocontainment Laboratory (RBL). In this proposal we describe the alignment of research goals and activities between the MRCE and RBL through the establishment of an Innate Immunity Core at the University of Missouri. Research Projects in the MRCE have a common theme to understand mechanisms of immune responses to priority pathogens, and participating researchers from five institutions collaborate to further this frontier. The MU RBL provides state of the art containment design and engineering as well as centralized resources and education for infectious disease research. Through the Innate Immunity Core (IIC) we will create experimental opportunities requiring access to live cell sorting and other immunological techniques on infected samples. Moreover, the IIC and the RBL are strucutred to permit flexibility and adaptation to the changing frontier of infectious disease research. Thus, the IIC provides a unique capability in region VII that creates opportunities for novel scientific achievements that further the research mission of the MRCE.

2002年，蓝带小组确定了生物防御的研究重点，包括优先考虑 病原体和广谱治疗剂的发展，以打击感染。其中包括两名 中心主题：1）发展对需要高度封闭的生物体的研究能力 实验室和2）集中的研究重点在十个联邦指定的地区。第七区 华盛顿大学指导中西部地区生物防御和新兴技术卓越中心 传染病研究（MRCE）。第七区的实验室扩大发生在维也纳大学， 密苏里州和NIAID区域生物防护实验室（RBL）。在本提案中，我们描述了 研究目标和活动之间的MRCE和RBL通过建立一个统一的 密苏里州大学的先天免疫核心。MRCE的研究项目有一个共同的主题 了解对优先病原体的免疫反应机制，参与研究的研究人员来自 五个机构合作推进这一领域。MU RBL提供最先进的安全壳设计 以及传染病研究的集中资源和教育。通过 先天免疫核心（IIC），我们将创造实验机会，需要获得活细胞分选， 其他免疫学技术。此外，IIC和RBL的结构允许 灵活性和适应性不断变化的传染病研究前沿。因此，IIC提供了一个 第七区域的独特能力，为新的科学成就创造机会， MRCE的研究使命。