疟疾寄生虫恶性疟原虫的性别特异性基因表达-猫眼课题宝

疟疾寄生虫恶性疟原虫的性别特异性基因表达

批准号：

8495258

负责人：

LIWANG CUI

金额：

$17.51万

依托单位：

PENNSYLVANIA STATE UNIVERSITY, THE

依托单位国家：

美国

项目类别：

财政年份：

2012

资助国家：

美国

项目状态：

已结题

起止时间：

2012-06-22 至 2014-05-31

来源：

https://reporter.nih.gov/project-details/8495258

关键词：

Address Adverse effects Antimalarials Biology Blood Cell Separation Commit Complex Coupled Culicidae Data Data Analyses Development Erythrocytes Female Gender Gene Expression Gene Expression Profile Gene Proteins Genes Genomics Glean Glucosephosphate Dehydrogenase Deficiency Goals Green Fluorescent Proteins Health Human Insecticides Interruption Invaded Knowledge Lead Life Cycle Stages Malaria Methods Molecular Parasites Pathway interactions Patients Pharmaceutical Preparations Phase Plasmodium Plasmodium berghei Plasmodium falciparum Population Post-Transcriptional Regulation Preparation Primaquine Process Proteins Proteome Proteomics Reporter Reporter Genes Research Rodent Role Sampling Sex Differentiation Sexual Development Shapes Sorting - Cell Movement Staging Systems Biology Technology Tubulin Vaccines Vision asexual comparative economic impact improved male novel promoter scale up sex socioeconomics success tool transcriptome sequencing transcriptomics transmission process vector vector mosquito

项目摘要

项目成果

LIWANG CUI的其他基金

相似基金

相关文献

中文摘要

翻译

点击翻译按钮获取中文摘要

英文摘要

DESCRIPTION (provided by applicant): With improved financial and technical supports, many malaria endemic nations are once again considering malaria elimination as their national goal of malaria control. To achieve this ambitious goal, one of the greatest challenges is interruption of malaria transmission worldwide. Sexual development of malaria parasite is essential for transmission of the parasite through mosquitoes. Despite its central role in the life cycle of malaria parasites, the mechanism of sexual development is still poorly understood, and this knowledge gap severely hinders the development of novel tools to interrupt malaria transmission. This project, built on our recent success in creating Plasmodium falciparum lines with male or female gametocytes tagged with a reporter gene, aims to determine the molecular differences between the two sexes of gametocytes. The comprehensive transcriptomic and proteomic data generated from this study will enable systems biology approaches to address the fundamental biology of sexual differentiation in malaria parasites. This information is also deemed critical for the development of novel drugs and vaccines for the interruption of malaria transmission.

期刊论文(0)

专著(0)

科研奖励(0)

会议论文

Training in Malaria Research in Myanmar

批准号：

10239898
项目类别：
资助金额：

$24.84万
财政年份：

2021
负责人：

LIWANG CUI
依托单位：

UNIVERSITY OF SOUTH FLORIDA

Training in Malaria Research in Myanmar

批准号：

10376369
项目类别：
资助金额：

$23.7万
财政年份：

2021
负责人：

LIWANG CUI
依托单位：

UNIVERSITY OF SOUTH FLORIDA

Transcriptomes and Proteomes of Plasmodium Vivax

批准号：

9241966
项目类别：
资助金额：

$16.97万
财政年份：

2016
负责人：

LIWANG CUI
依托单位：

PENNSYLVANIA STATE UNIVERSITY, THE

Molecular Mechanisms of Artemisinin Resistance

批准号：

10062860
项目类别：
资助金额：

$19.02万
财政年份：

2016
负责人：

LIWANG CUI
依托单位：

UNIVERSITY OF SOUTH FLORIDA

Puf-Mediated Translation Control in Plasmodium

批准号：

9109554
项目类别：
资助金额：

$36.79万
财政年份：

2014
负责人：

LIWANG CUI
依托单位：

PENNSYLVANIA STATE UNIVERSITY, THE

Puf-Mediated Translation Control in Plasmodium

批准号：

9314354
项目类别：
资助金额：

$36.75万
财政年份：

2014
负责人：

LIWANG CUI
依托单位：

PENNSYLVANIA STATE UNIVERSITY, THE

Antimalarial Drug Resistance in P. falciparum

批准号：

8500147
项目类别：
资助金额：

$31.34万
财政年份：

2013
负责人：

LIWANG CUI
依托单位：

PENNSYLVANIA STATE UNIVERSITY, THE

Administration of Southeast Asia Malaria Research Center

批准号：

8500153
项目类别：
资助金额：

$22.06万
财政年份：

2013
负责人：

LIWANG CUI
依托单位：

PENNSYLVANIA STATE UNIVERSITY, THE

Malaria Vector Population Genetic Division and Vector Competence in Hainan Island

批准号：

8210435
项目类别：
资助金额：

$6.92万
财政年份：

2012
负责人：

LIWANG CUI
依托单位：

PENNSYLVANIA STATE UNIVERSITY, THE

Sex-Specific Gene Expression in Malaria Parasite Plasmodium falciparum

批准号：

8385372
项目类别：
资助金额：

$22.35万
财政年份：

2012
负责人：

LIWANG CUI
依托单位：

PENNSYLVANIA STATE UNIVERSITY, THE

Malaria Vector Population Genetic Division and Vector Competence in Hainan Island

批准号：

8460098
项目类别：
资助金额：

$5.93万
财政年份：

2012
负责人：

LIWANG CUI
依托单位：

PENNSYLVANIA STATE UNIVERSITY, THE

Administration of Southeast Asia Malaria Research Center

批准号：

8311802
项目类别：
资助金额：

$16.62万
财政年份：

2011
负责人：

LIWANG CUI
依托单位：

PENNSYLVANIA STATE UNIVERSITY, THE

Antimalarial Drug Resistance in P. falciparum

批准号：

8311800
项目类别：
资助金额：

$43.77万
财政年份：

2011
负责人：

LIWANG CUI
依托单位：

PENNSYLVANIA STATE UNIVERSITY, THE

Southeast Asia Malaria Research Center

批准号：

10380169
项目类别：
资助金额：

$233.63万
财政年份：

2010
负责人：

LIWANG CUI
依托单位：

UNIVERSITY OF SOUTH FLORIDA

Southeast Asia Malaria Research Center

批准号：

8101219
项目类别：
资助金额：

$210.06万
财政年份：

2010
负责人：

LIWANG CUI
依托单位：

PENNSYLVANIA STATE UNIVERSITY, THE

Project-004

批准号：

10821540
项目类别：
资助金额：

$11.47万
财政年份：

2010
负责人：

LIWANG CUI
依托单位：

UNIVERSITY OF SOUTH FLORIDA

Malaria HATs in Transcription Regulation

批准号：

8133254
项目类别：
资助金额：

$14.31万
财政年份：

2010
负责人：

LIWANG CUI
依托单位：

PENNSYLVANIA STATE UNIVERSITY, THE

Antimalarial Drug Resistance in P. falciparum

批准号：

8005218
项目类别：
资助金额：

$28.57万
财政年份：

2010
负责人：

LIWANG CUI
依托单位：

PENNSYLVANIA STATE UNIVERSITY, THE

Administration of Southeast Asia Malaria Research Center

批准号：

8005222
项目类别：
资助金额：

$14.61万
财政年份：

2010
负责人：

LIWANG CUI
依托单位：

PENNSYLVANIA STATE UNIVERSITY, THE

Mechanism of artemisinin resistance in selected malaria parasite lines

批准号：

7779346
项目类别：
资助金额：

$22.2万
财政年份：

2010
负责人：

LIWANG CUI
依托单位：

PENNSYLVANIA STATE UNIVERSITY, THE

海外基金