Transcriptomes and Proteomes of Plasmodium Vivax
Transcriptomes and Proteomes of Plasmodium Vivax
批准号:
9241966
负责人:
LIWANG CUI
金额:
$16.97万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-03-15 至 2018-09-30
关键词:
AchievementAddressAffectAreaBenignBiologicalBiologyBloodCase ManagementCentral AsiaChloroquine resistanceClinicalClinical ManagementClinical PathologyCommunitiesCoupledCulicidaeCulture TechniquesDNA Microarray ChipDataDevelopmentDevelopmental BiologyDiseaseEpidemiologyErythrocytesGene ExpressionGenomeGenomicsGeographyHepatocyteHourHumanIn VitroInterruptionInvadedKineticsKnowledgeLeadLiverMalariaMass Spectrum AnalysisMeasuresMethodsMonkeysMorbidity - disease rateParasitesPharmaceutical PreparationsPlasmodiumPlasmodium falciparumPlasmodium vivaxPlayPopulationPost-Transcriptional RegulationPreparationPrevalencePrimaquineProductionProteinsProteomeProteomicsPublishingRecurrent diseaseResearchResourcesReticulocytesRoleSamplingSexual DevelopmentSoutheastern AsiaSporozoitesSurface AntigensSymptomsSystemSystems BiologyTechniquesTechnologyTimeVivax MalariaWorkanalytical toolasexualbasecomparativecomparative genomicsdrug discoverygene producthumanized mouseimprovedinnovationliver developmentmalaria transmissionmortalitymouse modelneglectnovel therapeuticsnovel vaccinesparasite genomepublic health relevancetranscriptometranscriptome sequencingtranscriptomicstransmission processtransmission-blocking vaccinetrendvaccine developmentvaccine discovery
中文摘要
英文摘要
DESCRIPTION (provided by applicant): Plasmodium vivax is the second most prevalent and the most geographically widespread malaria parasite, causing enormous morbidity and mortality in affected populations. Research on P. vivax malaria has lagged significantly behind, largely due to the lack of a continuous in vitro culture system. This parasite selectively invades reticulocytes, making long-term culture difficult. P. vivax gametocytes, which are responsible for transmission, are produced before the onset of the clinical symptoms. Though the first P. vivax genome was published in 2008, systematic comparison of the transcriptomes and proteomes of the asexual erythrocytic cycle is lacking and we know little about the developmental biology of P. vivax gametocytes. This project, built on recent advancement in humanized mouse model to study the liver stages of this parasite and our improved in vitro culture techniques for synchronous blood stages, aims to determine the temporal transcriptomes and proteomes during P. vivax asexual erythrocytic development and gametocytogenesis using RNA sequencing and mass spectrometry technologies, respectively. The comprehensive transcriptomic and proteomic data generated from this study will enable systems biology approaches to address the fundamental biology of asexual and sexual development of this neglected malaria parasite. This information is also deemed critical for the discovery of novel drugs and vaccines for the interruption of P. vivax transmission.
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批准号:10239898
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资助金额:$24.84万
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Administration of Southeast Asia Malaria Research Center
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资助金额:$22.06万
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财政年份:2012
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Sex-Specific Gene Expression in Malaria Parasite Plasmodium falciparum
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Malaria Vector Population Genetic Division and Vector Competence in Hainan Island
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资助金额:$5.93万
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财政年份:2012
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依托单位:
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财政年份:2011
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Southeast Asia Malaria Research Center
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海外基金