Training in Malaria Research in Myanmar

缅甸疟疾研究培训

• 批准号: 10239898
• 负责人: LIWANG CUI
• 金额: $ 24.84万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-15 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10239898
• 关键词: Accounting; Achievement; Address; Antimalarials; Area; Artemisinins; Beds; Country; Discipline; Disease; Educational workshop; Effectiveness; Ensure; Epidemiology; Faculty; Florida; Goals; Heterogeneity; Insecticide Resistance; Insecticides; Knowledge; Malaria; Measures; Medicine; Mentors; Monitor; Morbidity - disease rate; Myanmar; Needs Assessment; Plasmodium falciparum; Plasmodium vivax; Postdoctoral Fellow; Public Health; Research; Research Personnel; Residual state; Resistance; Scientist; Southeastern Asia; Technical Expertise; Technology; Training; Training Programs; Universities; base; career; clinical efficacy; design; doctoral student; innovation; member; mortality; multidisciplinary; programs; pyrethroid; resistance mechanism; vector; vector control; vector mosquito

Project Summary Malaria in the Greater Mekong Subregion (GMS) of Southeast Asia remains an important public health problem. Motivated by recent achievements in the reduction of malaria-related morbidity and mortality, six GMS countries have endorsed a regional malaria elimination plan with the ultimate goal to wholly eliminate malaria by 2030. However, this ambitious plan encounters a battery of challenges that must be addressed urgently. In the GMS, malaria shows tremendous heterogeneity in disease distribution, with Myanmar accounting for nearly half of the region confirmed malaria cases. The recent emergence of artemisinin resistance in Plasmodium falciparum and deteriorating efficacy of the frontline treatment for Plasmodium vivax are major concerns for malaria elimination. Furthermore, the emergence of insecticide resistance in major malaria vectors compromises the effectiveness of the core vector control measures such as insecticide-treated bed nets and indoor residual spraying. Despite the need for strengthened research to address these problems, there is a critical shortage in a well-trained workforce in malaria research in Myanmar. Therefore, this training program will address key knowledge gaps in malaria research, focusing on three scientific areas. Specifically, we aim to understand the changing malaria epidemiology in this region, to closely monitor the clinical efficacies of antimalarial drugs and elucidate the underlying resistance mechanisms, and to determine the extent, distribution, and mechanisms of pyrethroid resistance in major malaria vector mosquitoes. Within this training program, mentors of diverse scientific disciplines from the University of South Florida and University of Medicine Magway will join forces to offer multidisciplinary training in innovative approaches that address critical problems in the current malaria elimination campaign in this region. Based on training needs assessment, we propose to use a double-track training mechanism: 1) long-term training of three junior faculty members, three postdoctoral fellows and six PhD students, and 2) short-term training of endemic country scientists through annual short courses and workshops. The overall training paradigm designed in this application will ensure that all trainees obtain the required set of technical skills and intellectual expertise to conduct independent research on malaria. In addition, this training program will serve as an important platform for the transfer of enabling technologies to endemic-area scientists. By advancing the careers of these trainees, this program aims to build a critical mass of investigators and a necessary intellectual network in Myanmar to focus on malaria research.

项目摘要 东南亚大湄公河次区域（GMS）的疟疾仍然是一个重要的公共卫生问题， 问题.鉴于最近在减少与疟疾有关的发病率和死亡率方面取得的成就， 大湄公河次区域国家核可了一项区域消除疟疾计划，其最终目标是彻底消除 疟疾到2030年然而，这一雄心勃勃的计划遇到了一系列必须解决的挑战 紧急。在大湄公河次区域，疟疾在疾病分布上表现出巨大的异质性，缅甸和 占该地区确诊疟疾病例的近一半。最近出现的青蒿素 恶性疟原虫的耐药性和间日疟原虫一线治疗效果的恶化 是消灭疟疾的主要问题。此外，杀虫剂抗药性的出现， 疟疾病媒损害了核心病媒控制措施的有效性， 蚊帐和室内滞留喷洒。尽管需要加强研究来解决这些问题， 缅甸严重缺乏训练有素的疟疾研究工作人员。因此，本次培训 该计划将解决疟疾研究中的关键知识差距，重点是三个科学领域。具体地说， 我们的目标是了解该地区疟疾流行病学的变化，密切监测临床疗效， 抗疟药物的耐药性，阐明潜在的耐药机制，并确定程度， 主要疟疾病媒蚊子对拟除虫菊酯的抗药性分布和机制。在这次培训中 计划，来自南佛罗里达大学和佛罗里达大学的不同科学学科的导师。 医学马圭将联手提供创新方法的多学科培训，以解决关键的 目前该地区消灭疟疾运动中存在的问题。根据培训需求评估，我们 建议采用双轨制培养机制：1）长期培养三名初级教员， 博士后研究员和6名博士生，以及2）通过以下方式对地方病国家的科学家进行短期培训： 年度短期课程和讲习班。本应用程序中设计的整体培训模式将确保 所有受训人员都获得了进行独立研究所需的技术技能和知识专长 关于疟疾此外，这一培训方案将作为一个重要平台， 技术到地方科学家。通过推进这些学员的职业生涯，该计划旨在建立 在缅甸建立足够数量的调查人员和必要的知识网络，以专注于疟疾研究。