Sex-Specific Gene Expression in Malaria Parasite Plasmodium falciparum

疟疾寄生虫恶性疟原虫的性别特异性基因表达

基本信息

  • 批准号:
    8385372
  • 负责人:
  • 金额:
    $ 22.35万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-06-22 至 2014-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): With improved financial and technical supports, many malaria endemic nations are once again considering malaria elimination as their national goal of malaria control. To achieve this ambitious goal, one of the greatest challenges is interruption of malaria transmission worldwide. Sexual development of malaria parasite is essential for transmission of the parasite through mosquitoes. Despite its central role in the life cycle of malaria parasites, the mechanism of sexual development is still poorly understood, and this knowledge gap severely hinders the development of novel tools to interrupt malaria transmission. This project, built on our recent success in creating Plasmodium falciparum lines with male or female gametocytes tagged with a reporter gene, aims to determine the molecular differences between the two sexes of gametocytes. The comprehensive transcriptomic and proteomic data generated from this study will enable systems biology approaches to address the fundamental biology of sexual differentiation in malaria parasites. This information is also deemed critical for the development of novel drugs and vaccines for the interruption of malaria transmission. PUBLIC HEALTH RELEVANCE: Sexual development is obligatory for the transmission of malaria parasites through mosquito vectors. Interruption of malaria transmission is considered one of the greatest challenges during the malaria elimination phase. However, the mechanism of sexual differentiation in malaria parasites is still poorly understood. This project is built onour recent success to genetically manipulate the sexual stage parasites and to sort out the two sexes of the gametocyte stages, aiming to determine the differences between the male and female parasite using advanced high-throughput gene expression and protein identification approaches.
随着财政和技术支持的改善,许多疟疾流行国家再次考虑将消除疟疾作为其疟疾控制的国家目标。为了实现这一宏伟目标,最大的挑战之一是在全世界阻断疟疾传播。疟原虫的性发育对于疟原虫通过蚊子传播至关重要。尽管它在生命中扮演着重要角色 尽管疟疾寄生虫的周期很短,但性发育机制仍然知之甚少,这种知识差距严重阻碍了中断疟疾传播的新工具的开发。这个项目,建立在我们最近成功地创建恶性疟原虫线与男性或女性配子体标记的报告基因,旨在确定配子体的两性之间的分子差异。从这项研究中产生的综合转录组学和蛋白质组学数据将使系统生物学方法能够解决疟疾寄生虫性别分化的基本生物学问题。这一信息对于开发阻断疟疾传播的新药和疫苗也至关重要。 公共卫生相关性:性发育是通过蚊子传播疟疾寄生虫的必要条件。阻断疟疾传播被认为是消除疟疾阶段最大的挑战之一。然而,疟原虫性别分化的机制仍然知之甚少。该项目是建立在我们最近成功地遗传操纵有性阶段寄生虫,并整理出配子体阶段的两性,旨在确定男性和女性之间的差异寄生虫使用先进的高通量基因表达和蛋白质鉴定方法。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

LIWANG CUI其他文献

LIWANG CUI的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('LIWANG CUI', 18)}}的其他基金

Training in Malaria Research in Myanmar
缅甸疟疾研究培训
  • 批准号:
    10239898
  • 财政年份:
    2021
  • 资助金额:
    $ 22.35万
  • 项目类别:
Training in Malaria Research in Myanmar
缅甸疟疾研究培训
  • 批准号:
    10376369
  • 财政年份:
    2021
  • 资助金额:
    $ 22.35万
  • 项目类别:
Transcriptomes and Proteomes of Plasmodium Vivax
间日疟原虫的转录组和蛋白质组
  • 批准号:
    9241966
  • 财政年份:
    2016
  • 资助金额:
    $ 22.35万
  • 项目类别:
Molecular Mechanisms of Artemisinin Resistance
青蒿素耐药的分子机制
  • 批准号:
    10062860
  • 财政年份:
    2016
  • 资助金额:
    $ 22.35万
  • 项目类别:
Puf-Mediated Translation Control in Plasmodium
疟原虫中 Puf 介导的翻译控制
  • 批准号:
    9109554
  • 财政年份:
    2014
  • 资助金额:
    $ 22.35万
  • 项目类别:
Puf-Mediated Translation Control in Plasmodium
疟原虫中 Puf 介导的翻译控制
  • 批准号:
    9314354
  • 财政年份:
    2014
  • 资助金额:
    $ 22.35万
  • 项目类别:
Antimalarial Drug Resistance in P. falciparum
恶性疟原虫的抗疟药物耐药性
  • 批准号:
    8500147
  • 财政年份:
    2013
  • 资助金额:
    $ 22.35万
  • 项目类别:
Administration of Southeast Asia Malaria Research Center
东南亚疟疾研究中心管理局
  • 批准号:
    8500153
  • 财政年份:
    2013
  • 资助金额:
    $ 22.35万
  • 项目类别:
Malaria Vector Population Genetic Division and Vector Competence in Hainan Island
海南岛疟疾媒介群体遗传划分及媒介能力
  • 批准号:
    8210435
  • 财政年份:
    2012
  • 资助金额:
    $ 22.35万
  • 项目类别:
Sex-Specific Gene Expression in Malaria Parasite Plasmodium falciparum
疟疾寄生虫恶性疟原虫的性别特异性基因表达
  • 批准号:
    8495258
  • 财政年份:
    2012
  • 资助金额:
    $ 22.35万
  • 项目类别:

相似海外基金

Unraveling Adverse Effects of Checkpoint Inhibitors Using iPSC-derived Cardiac Organoids
使用 iPSC 衍生的心脏类器官揭示检查点抑制剂的副作用
  • 批准号:
    10591918
  • 财政年份:
    2023
  • 资助金额:
    $ 22.35万
  • 项目类别:
Optimization of mRNA-LNP vaccine for attenuating adverse effects and analysis of mechanism behind adverse effects
mRNA-LNP疫苗减轻不良反应的优化及不良反应机制分析
  • 批准号:
    23K15383
  • 财政年份:
    2023
  • 资助金额:
    $ 22.35万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Elucidation of adverse effects of combined exposure to low-dose chemicals in the living environment on allergic diseases and attempts to reduce allergy
阐明生活环境中低剂量化学品联合暴露对过敏性疾病的不良影响并尝试减少过敏
  • 批准号:
    23H03556
  • 财政年份:
    2023
  • 资助金额:
    $ 22.35万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Green tea-based nano-enhancer as an adjuvant for amplified efficacy and reduced adverse effects in anti-angiogenic drug treatments
基于绿茶的纳米增强剂作为抗血管生成药物治疗中增强疗效并减少不良反应的佐剂
  • 批准号:
    23K17212
  • 财政年份:
    2023
  • 资助金额:
    $ 22.35万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Effects of Tobacco Heating System on the male reproductive function and towards to the reduce of the adverse effects.
烟草加热系统对男性生殖功能的影响以及减少不利影响。
  • 批准号:
    22H03519
  • 财政年份:
    2022
  • 资助金额:
    $ 22.35万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Mitigating the Adverse Effects of Ultrafines in Pressure Filtration of Oil Sands Tailings
减轻油砂尾矿压力过滤中超细粉的不利影响
  • 批准号:
    563657-2021
  • 财政年份:
    2022
  • 资助金额:
    $ 22.35万
  • 项目类别:
    Alliance Grants
1/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
1/4-破译ECT结果和不良反应的机制(DECODE)
  • 批准号:
    10521849
  • 财政年份:
    2022
  • 资助金额:
    $ 22.35万
  • 项目类别:
4/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
4/4-破译ECT结果和不良反应的机制(DECODE)
  • 批准号:
    10671022
  • 财政年份:
    2022
  • 资助金额:
    $ 22.35万
  • 项目类别:
2/4 Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
2/4 ECT 结果和不良反应的破译机制(DECODE)
  • 批准号:
    10670918
  • 财政年份:
    2022
  • 资助金额:
    $ 22.35万
  • 项目类别:
Adverse Effects of Using Laser Diagnostics in High-Speed Compressible Flows
在高速可压缩流中使用激光诊断的不利影响
  • 批准号:
    RGPIN-2018-04753
  • 财政年份:
    2022
  • 资助金额:
    $ 22.35万
  • 项目类别:
    Discovery Grants Program - Individual
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了