Sex-Specific Gene Expression in Malaria Parasite Plasmodium falciparum
疟疾寄生虫恶性疟原虫的性别特异性基因表达
基本信息
- 批准号:8385372
- 负责人:
- 金额:$ 22.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-06-22 至 2014-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdverse effectsAntimalarialsBiologyBloodCell SeparationCommitComplexCoupledCulicidaeDataData AnalysesDevelopmentErythrocytesFemaleGenderGene ExpressionGene Expression ProfileGene ProteinsGenesGenomicsGleanGlucosephosphate Dehydrogenase DeficiencyGoalsGreen Fluorescent ProteinsHealthHumanInsecticidesInterruptionInvadedKnowledgeLeadLife Cycle StagesMalariaMethodsMolecularParasitesPathway interactionsPatientsPharmaceutical PreparationsPhasePlasmodiumPlasmodium bergheiPlasmodium falciparumPopulationPost-Transcriptional RegulationPreparationPrimaquineProcessProteinsProteomeProteomicsRNAReporterReporter GenesResearchRodentRoleSamplingSex DifferentiationSexual DevelopmentShapesSorting - Cell MovementStagingSystems BiologyTechnologyTubulinVaccinesVisionasexualcomparativeeconomic impactimprovedmalenovelpromoterscale upsexsocioeconomicssuccesstooltranscriptomicstransmission processvectorvector mosquito
项目摘要
DESCRIPTION (provided by applicant): With improved financial and technical supports, many malaria endemic nations are once again considering malaria elimination as their national goal of malaria control. To achieve this ambitious goal, one of the greatest challenges is interruption of malaria transmission worldwide. Sexual development of malaria parasite is essential for transmission of the parasite through mosquitoes. Despite its central role in the life
cycle of malaria parasites, the mechanism of sexual development is still poorly understood, and this knowledge gap severely hinders the development of novel tools to interrupt malaria transmission. This project, built on our recent success in creating Plasmodium falciparum lines with male or female gametocytes tagged with a reporter gene, aims to determine the molecular differences between the two sexes of gametocytes. The comprehensive transcriptomic and proteomic data generated from this study will enable systems biology approaches to address the fundamental biology of sexual differentiation in malaria parasites. This information is also deemed critical for the development of novel drugs and vaccines for the interruption of malaria transmission.
PUBLIC HEALTH RELEVANCE: Sexual development is obligatory for the transmission of malaria parasites through mosquito vectors. Interruption of malaria transmission is considered one of the greatest challenges during the malaria elimination phase. However, the mechanism of sexual differentiation in malaria parasites is still poorly understood. This project is built onour recent success to genetically manipulate the sexual stage parasites and to sort out the two sexes of the gametocyte stages, aiming to determine the differences between the male and female parasite using advanced high-throughput gene expression and protein identification approaches.
随着财政和技术支持的改善,许多疟疾流行国家再次考虑将消除疟疾作为其疟疾控制的国家目标。为了实现这一宏伟目标,最大的挑战之一是在全世界阻断疟疾传播。疟原虫的性发育对于疟原虫通过蚊子传播至关重要。尽管它在生命中扮演着重要角色
尽管疟疾寄生虫的周期很短,但对性发育的机制仍然知之甚少,这一知识差距严重阻碍了阻断疟疾传播的新工具的开发。该项目建立在我们最近成功地用标记有报告基因的雄性或雌性配子体创建恶性疟原虫系的基础上,旨在确定两种性别的配子体之间的分子差异。从这项研究中产生的综合转录组学和蛋白质组学数据将使系统生物学方法能够解决疟疾寄生虫性别分化的基本生物学问题。这一信息对于开发阻断疟疾传播的新药和疫苗也至关重要。
公共卫生相关性:性发育是通过蚊子传播疟疾寄生虫的必要条件。阻断疟疾传播被认为是消除疟疾阶段最大的挑战之一。然而,疟原虫性别分化的机制仍然知之甚少。该项目是建立在我们最近成功地遗传操纵有性阶段寄生虫,并整理出配子体阶段的两性,旨在确定男性和女性之间的差异寄生虫使用先进的高通量基因表达和蛋白质鉴定方法。
项目成果
期刊论文数量(0)
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{{ truncateString('LIWANG CUI', 18)}}的其他基金
Transcriptomes and Proteomes of Plasmodium Vivax
间日疟原虫的转录组和蛋白质组
- 批准号:
9241966 - 财政年份:2016
- 资助金额:
$ 22.35万 - 项目类别:
Puf-Mediated Translation Control in Plasmodium
疟原虫中 Puf 介导的翻译控制
- 批准号:
9109554 - 财政年份:2014
- 资助金额:
$ 22.35万 - 项目类别:
Puf-Mediated Translation Control in Plasmodium
疟原虫中 Puf 介导的翻译控制
- 批准号:
9314354 - 财政年份:2014
- 资助金额:
$ 22.35万 - 项目类别:
Administration of Southeast Asia Malaria Research Center
东南亚疟疾研究中心管理局
- 批准号:
8500153 - 财政年份:2013
- 资助金额:
$ 22.35万 - 项目类别:
Malaria Vector Population Genetic Division and Vector Competence in Hainan Island
海南岛疟疾媒介群体遗传划分及媒介能力
- 批准号:
8210435 - 财政年份:2012
- 资助金额:
$ 22.35万 - 项目类别:
Sex-Specific Gene Expression in Malaria Parasite Plasmodium falciparum
疟疾寄生虫恶性疟原虫的性别特异性基因表达
- 批准号:
8495258 - 财政年份:2012
- 资助金额:
$ 22.35万 - 项目类别:
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