Global Health Research and Training in HIV and Tuberculosis

艾滋病毒和结核病的全球健康研究和培训

• 批准号: 8449115
• 负责人: Daniel W Fitzgerald
• 金额: $ 17.54万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8449115
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adverse effects; Africa; Antitubercular Agents; Biological Markers; Cardiovascular Diseases; Case-Control Studies; Cells; Centers for Disease Control and Prevention (U.S.); Cervical; Cervical Intraepithelial Neoplasia; Chemopreventive Agent; Chronic; Chronic Disease; Cirrhosis; Cities; Clinical; Clinical Trials; Clinical Trials Design; Code; Cohort Studies; Crowding; Data; Data Collection; Diagnosis; Dinoprostone; Disease Outbreaks; Drug resistance; Earthquakes; Environment; Enzymes; Epidemiology; Event; Faculty; Female; Foundations; Funding; Future; Gene Expression; Genital system; Genitourinary system; Goals; Good Clinical Practice; Grant; HIV; HIV Infections; HIV vaccine; Haiti; Health Services Research; Human Papillomavirus; Incidence; Infection; Inflammation; Inflammatory; International; Investigation; Kidney Diseases; Knowledge; Laboratories; Lead; Leadership; Learning; Longitudinal Studies; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Mass Spectrum Analysis; Master of Science; Mediator of activation protein; Metabolic; Metabolism; Mid-Career Clinical Scientist Award (K24); Monitor; Multi-Institutional Clinical Trial; Multidrug-Resistant Tuberculosis; National Institute of Allergy and Infectious Disease; Nested Case-Control Study; Outpatients; Patients; Pharmaceutical Preparations; Physicians; Pulmonary Tuberculosis; Randomized; Regimen; Research; Research Project Grants; Research Training; Risk; Role; Sampling; Schistosomiasis; Scientist; Serum; Site; Sputum; Tanzania; Technology; Telecommunications; Testing; Therapy Clinical Trials; Time; Training; Training Programs; Tuberculosis; United States; United States National Institutes of Health; Urine; Woman; Women' s Role; Work; antiretroviral therapy; career; case finding; clinical epidemiology; cohort; doctoral student; drug sensitivity; experience; global health; insight; international center; medical schools; novel; patient oriented research; pre-doctoral; prevent; small molecule; therapy design; time use; treatment center; tuberculosis drugs; tuberculosis treatment; tumorigenesis; young woman

DESCRIPTION (provided by applicant): My long-term career goal is to develop a global health research-training program for United States and international physician-scientists with a focus on HIV and tuberculosis. The goals of this K24 proposal are to train physician scientists and outstanding pre-doctoral students through the conduct of research primarily in Haiti, and also in Tanzania and to conduct a new research project on HIV induced chronic inflammation in Haiti. United States trainees will spend ~60% of their time at international research sites in Haiti and Tanzania, which have on-site Weill Cornell faculty, advanced telecommunications, and outstanding environments for research training. Physician-scientists may pursue a Master of Science (MS) in Clinical Epidemiology and Health Services Research at Weill Cornell Medical College. The research strategy includes a new research project in Haiti to be supported by the K24 award on HIV induced chronic inflammation (AIM 1), currently funded projects in Haiti (AIMS 2 - 5), and a currently funded project at a new research site in Mwanza, Tanzania (AIM 6). The common theme is that all the projects have patient-oriented research on AIDS and TB as the focus and will serve as training vehicles for research trainees. The projects include the following: 1. Chronic inflammation as a consequence of delayed ART: biomarkers and sequelae 2. Cervical cancer in HIV infected women: role of prostaglandin E2 3. Tuberculosis biomarkers for diagnosis and for monitoring therapy 4. HIV vaccine and ART clinical trials 5. Multidrug resistant tuberculosis surveillance and control 6. Female urogenital schistosomiasis and HIV interactions Five of the projects involve long-term study of cohorts in Haiti, and the sixth a cohot in Tanzania. There are both clinical and laboratory aspects to all studies which offer trainees broad experience. Trainees learn through the conduct of an independent project and the opportunity to interact with colleagues working on studies other than their own.

描述（由申请人提供）：我的长期职业目标是为美国和国际医师科学家制定全球健康研究培训计划，重点关注艾滋病毒和结核病。 K24 提案的目标是通过主要在海地和坦桑尼亚进行研究来培训医师科学家和优秀的博士前学生，并在海地开展一个关于艾滋病毒引起的慢性炎症的新研究项目。美国学员将有大约 60% 的时间在海地和坦桑尼亚的国际研究中心度过，这些中心拥有威尔康奈尔大学的现场教员、先进的电信和出色的研究培训环境。医生科学家可以在威尔康奈尔医学院攻读临床流行病学和健康服务研究理学硕士学位 (MS)。该研究战略包括由 K24 奖资助的关于艾滋病毒引起的慢性炎症 (AIM 1) 的海地新研究项目、目前在海地资助的项目 (AIMS 2 - 5) 以及目前在坦桑尼亚姆万扎新研究基地资助的项目 (AIM 6)。共同的主题是，所有项目都以以患者为中心的艾滋病和结核病研究为重点，并将作为研究实习生的培训工具。这些项目包括以下内容： 1. 延迟 ART 造成的慢性炎症：生物标志物和后遗症 2. HIV 感染妇女的宫颈癌：前列腺素 E2 的作用 3. 用于诊断和监测治疗的结核病生物标志物 4. HIV 疫苗和 ART 临床试验 5. 耐多药结核病监测和控制 6. 女性泌尿生殖道血吸虫病和 艾滋病毒相互作用 其中五个项目涉及对海地群体的长期研究，第六个项目涉及坦桑尼亚的群体研究。所有研究都涉及临床和实验室方面，为学员提供广泛的经验。学员通过独立项目的开展以及与从事其他研究的同事互动的机会来学习。