Chemistry/ Radiochemistry

导言。ICMlC@Stanford的化学/放射化学专业资源(SRI)是一个独特的 设施，旨在成为我们现有分子成像的不可或缺的组成部分和重要补充 斯坦福大学(Stanford)f http://mips.stanford.edu/).项目这个ICMIC@Stanford的主要使命 专业资源提供正电子发射的设计、合成和生产方面的专业知识 断层扫描(PET)、单光子发射计算机断层扫描(SPECT)和非放射性 ICMIC@Stanford的成像探针(即近红外荧光(NIRF)、磁共振) 调查人员。 斯坦福大学分子成像计划(MIPS)是2003年在医学院内建立的一个跨学科研究计划，由Sanjiv Sam Gambhir博士和Christopher Contag博士指导。该计划与跨学科生物科学领域的生物X计划(http://biox.stanford.edu/)和BNNG)紧密联系在一起，这些计划由来自斯坦福大学工程学院、医学院和人文科学学院的科学家共同完成。MIPS拥有放射性制药设施、小型动物成像设施(http://sci3.stanford.edu/)，)和放射科的临床成像设备，包括计算机断层扫描(CT)、磁共振成像(MRI)、正电子发射断层扫描/CT(正电子发射断层扫描/CT)和单光子发射计算机断层扫描(SPECT)。核医学部(http://nuclearmedicine.stanford.edu/)是 还积极与MIPS挂钩。 除了克拉克、卢卡斯和爱德华兹大楼附近现有的化学/放射化学资源外，2004年4月，一台GE PETTRACE(16.5 MeV)回旋加速器被转移到放射化学核心设施(RCF)。2005年8月，MIPS打开了RCF的大门，并开始设置和验证包括回旋加速器在内的所有新仪器和设备。回旋加速器通常提供[[18]F]氟化物(氟-18：Ti/2=109，8min)、f�F]氟气(氟-18：Tv2=109.8分钟)、[^Cj二氧化碳(碳-11：Ti/2=20.4min)和f^Nj氨(氮-13：Ti/2=9.97min)，以满足目前MIPS的大部分PET放射化学需求。虽然我们的回旋加速器可以产生氧-15(ti/2=2.04分钟)，但常规生产不能 由于设施和正电子发射计算机断层扫描仪之间的距离较远，因此，铟-111(ti/2=2.8d)和Y-90(ti/2=h)可直接从珀金-埃尔默公司购买。镓-68(ti/2=68min)来自我们从回旋加速器(德国美因茨)购买的Ge-68/Ga-68发电机。钚-177是从密苏里大学研究反应堆中心获得的(见本节末尾凯西·卡特勒的支持信)。我们目前从威斯康星大学麦迪逊分校获得了铜(ti/2=12.8h)、Y-86(ti/2=14.6h)和锆-89(见R.Jerome Nickles的支持函)，从俄罗斯莫斯科的RITVERC GmbH获得了碘124(ti/2=4.2d)。我们正在探索安装固体靶和相关处理设备的可能性，以便在内部生产这些放射性同位素。

Introduction. The Chemistry/Radiochemistry Specialized Resource (SRI) ofthe ICMlC@Stanford is a unique facility, designed to be an integral component and important addition to our existing Molecular Imaging Program at Stanford (MIPS) fhttp://mips.stanford.edu/). The primary mission of this ICMIC@Stanford Specialized Resource is to provide expertise in design, synthesis, and production of positron emission tomography (PET), single photon emission computed tomography (SPECT), and non-radioactive imaging probes (i.e., Near-Infrared Fluorescence (NIRF), Magnetic Resonance) for ICMIC@Stanford investigators. The Molecular Imaging Program at Stanford (MIPS) is an interdisciplinary research program founded in 2003 within the School of Medicine and directed by Drs. Sanjiv Sam Gambhir and Christopher Contag. The Program is integrally linked with the Bio-X Program in interdisciplinary biosciences (http://biox.stanford.edu/) and bnngs together scientists from the Schools of Engineering, Medicine, and Humanities & Sciences at Stanford. MIPS has a radiopharmaceutical facility, a small animal imaging facility (http://sci3.stanford.edu/), and clinical imaging equipment in the Department of Radiology including computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography combined with CT (PET/CT), and single photon emission computed tomography (SPECT). The Division of Nuclear Medicine (http://nuclearmedicine.stanford.edu/) is also actively linked to MIPS. In addition to the nearby existing chemistry/radiochemistry resources located within the Clark, Lucas, and Edwards buildings, a GE PETtrace (16.5 MeV) cyclotron was moved into the Radiochemistry Core Facility (RCF) in April 2004. In August 2005, MIPS opened the doors to the RCF and began setting up and validating all the new instruments and equipment including the cyclotron. The cyclotron routinely provides [ [18] F]fluoride (fluorine-18: ti/2 = 109,8 min), f �F]fluorine gas (fluorine-18: tv2 = 109.8 min), [^^Cjcarbon dioxide (carbon-11: ti/2 = 20.4 min), and f ^Njammonia (nitrogen-13: ti/2 = 9.97 min) to meet most of the current PET radiochemistry needs in MIPS. Although our cyclotron can produce oxygen-15 (ti/2 = 2.04 min), routine production does not occur due to the long distance between the facility and the PET scanners, lndium-111 (ti/2 = 2.8 d) and yttrium- 90 (ti/2 = 64 h) are purchased directly from Perkin-Elmer. Gallium-68 (ti/2 = 68 min) is milked from our Ge-68/Ga-68 generator that was purchased from Cyclotron Instruments (Mainz, Germany). Lutetium-177 is acquired from the University of Missouri Research Reactor Center (see Letter of Support from Cathy Cutler at the end of this section). We currently obtain copper-64 (ti/2= 12.8 h), yttrium-86 (ti/2= 14.6 h), and zirconium-89 from the University of Wisconsin-Madison (see Letter of Support from R. Jerome Nickles), and iodine-124 (ti/2= 4.2 day) from RITVERC GmbH (Moscow, Russia). We are exploring possibilities of installing solid targets and associated processing apparatuses for in-house production of these radioisotopes.