Conduct of studies to evaluate the toxicity and carcinogenicity of multiwalled carbon nanotubes in laboratory animals for the National Toxicology Program (NTP)

为国家毒理学计划（NTP）开展研究，评估多壁碳纳米管对实验动物的毒性和致癌性

• 批准号: 10024928
• 负责人: BARNEY SPARROW
• 金额: $ 151.46万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2020-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10024928
• 关键词: Adverse effects; Carbon Nanotubes; Chemicals; Chronic; Data; Development; Ensure; Environmental Exposure; Evaluation; Exposure to; Goals; Hazard Identification; Hazardous Chemicals; Health; Histopathology; Human; Industrialization; Inhalation; Laboratory Animals; Lung; Mus; Nanotechnology; National Toxicology Program; Phase; Rattus; Reporting; Risk Assessment; Risk Factors; Toxic effect; Toxicity Tests; Toxicology; carcinogenicity; disorder prevention; immunotoxicity; public health research; sound

The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves characterization of the chronic toxicity and carcinogenicity of multiwalled carbon nanotubes (MWCNT) via whole body inhalation. MWCNT have a wide variety of industrial applications and the use is increasing rapidly. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of MWCNT in rats and mice and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to MWCNT. Keywords: toxicity, carcinogenicity, inhalation, nanotechnology multiwalled carbon nanotubes, lung

该项目的目标是为国家毒理学计划（NTP）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要适当进行毒理学研究，以确保所得数据可靠。该项目涉及多壁碳纳米管（MWCNT）通过全身吸入的慢性毒性和致癌性的表征。多壁碳纳米管具有广泛的工业应用，并且使用正在迅速增加。 该项目的数据将用于制定关于多壁碳纳米管在大鼠和小鼠中的潜在毒性和致癌性的合理科学结论，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。此外，公众可充分了解接触多壁碳纳米管所产生的风险因素。 关键词：毒性，致癌性，吸入，纳米技术多壁碳纳米管，肺