Nanoscale structure and phase composition of sound and carious enamel
完好牙釉质和龋牙釉质的纳米结构和相组成
基本信息
- 批准号:8954557
- 负责人:
- 金额:$ 14.72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-07-10 至 2016-12-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAcidsAdultAffectAnimalsApatitesArchitectureBacteriaBicuspidBiologicalBiometryBreathingCarbonatesCaries preventionCariogenic DietCerealsChemicalsChemistryChildChronic DiseaseClinicalCommunicable DiseasesComplexCorrosionDataDentalDental EnamelDental cariesDetectionDevelopmentDiffuseDiffusionDurapatiteEarly DiagnosisEnsureEquilibriumEtiologyEventEvolutionExpenditureFluoridesFutureGoalsHeterogeneityHomeostasisHumanImageImaging DeviceImaging TechniquesIndividualIonsKnowledgeLengthLesionLifeLinkLiteratureLongitudinal StudiesMagnesiumMicrobial BiofilmsMineralsMinorModelingMorbidity - disease rateMusNanostructuresOral cavityOrthodonticOutcomePhasePigmentsPilot ProjectsPlayProductionPublic HealthRattusResearchResidual stateResistanceResolutionRoentgen RaysRoleSalivaSchemeScienceSeveritiesSocietiesSolubilitySonSpectrum AnalysisStagingStructureSurfaceSurgical ManagementTechniquesTissuesTooth structureWhite SpotsWistar Ratsabsorptionbasecalcium phosphatecostdemineralizationdensitydental surgerydesignexperiencein vivoinnovationinsightmimeticsmineralizationminimally invasivemodel developmentnanocompositenanoscaleorganic acidpreventpublic health relevanceremineralizationresearch studyrestorationretinal rodssoundtomography
项目摘要
DESCRIPTION (provided by applicant): Caries, or tooth decay, is the consequence between an imbalance between demineralization of enamel due to production of organic acids by bacteria of the plaque biofilm, and remineralization from saliva. Caries has an extremely high morbidity, with 60-90% of children and nearly 100% of adults worldwide having had caries, ac- cording to the WHO. As the most prevalent chronic disease, caries is an important public health problem and contributes significantly to the exorbitant dental expenditure - about $110 billion/year in the US alone. There is, therefore, a clear and present need for innovating caries prevention, early detection, and minimally invasive restoration. A major bottleneck is our lack of understanding of the etiology of enamel caries at the nanoscale. This is a consequence of the difficulties encountered in characterizing structure and chemistry of enamel, a complex hierarchical nanocomposite with significant heterogeneity in structure and composition. Herein we show that atom probe tomography (APT), a chemical imaging tool with unrivaled spatial resolution (<0.4 nm) and unbiased chemical selectivity, is uniquely able to deliver quantitative structural and compositional information at the required resolution. Specifically, we discovered the presence magnesium-rich amorphous inter- granular phase (AIGP) that is also enriched in carbonate, and residual organic matter. We further show that this AIGP is preferentially dissolved in acid and provides a short circuit diffusion path for fluoride. Based on this preliminary data, we hypothesize that the Mg-rich AIGP plays an integral role in enamel de- and remineralization and the development of caries lesions. A major goal of this application is to quantitatively compare the distribution and composition of the AIGP in pristine outer enamel and the surface zone enamel of carious sub surface lesions. We will do so by carrying out analyses of enamel on human teeth extracted for orthodontic rea- sons, using both APT and correlative techniques. A second goal is to establish an in vivo rat model for the development of caries lesions in the PI's lab for future longitudinal studies.
项目成果
期刊论文数量(0)
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Derk Joester其他文献
Derk Joester的其他文献
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{{ truncateString('Derk Joester', 18)}}的其他基金
Enamel atlas: systems-level amelogenesis tools at multiple scales
牙釉质图谱:多尺度的系统级釉质生成工具
- 批准号:
10467066 - 财政年份:2021
- 资助金额:
$ 14.72万 - 项目类别:
Enamel atlas: systems-level amelogenesis tools at multiple scales
牙釉质图谱:多尺度的系统级釉质生成工具
- 批准号:
10416107 - 财政年份:2021
- 资助金额:
$ 14.72万 - 项目类别:
Enamel atlas: systems-level amelogenesis tools at multiple scales
牙釉质图谱:多尺度的系统级釉质生成工具
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10670353 - 财政年份:2021
- 资助金额:
$ 14.72万 - 项目类别:
SYNTHESIS AND AGGREGATION OF CALCIUM CARBONATE IN PHOSPHOLIPID VESICLES
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8361302 - 财政年份:2011
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$ 14.72万 - 项目类别:
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