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Investigation of the molecular basis of variation in thermal and organic acid inactivation of Salmonella enterica (KINGSLEY_Q18CASEN)

研究肠沙门氏菌热灭活和有机酸灭活变化的分子基础 (KINGSLEY_Q18CASEN)

基本信息

批准号：
1941421
负责人：
金额：
--
依托单位：
University of East Anglia
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1941421
关键词：
Investigation molecular basis variation thermal

项目摘要

The aim of this project is to investigate the molecular basis for the inactivation of Salmonella by combinations of mild thermal treatments and recommend critical limits to ensure pathogen inactivation and product safety. We will test the central hypothesis that genetic variation of pathogen strains results in differences in inactivation, especially at mild heating conditions, and therefore the associated risk to food safety and consumer health. The rationale for the study is that there is a gap in the scientific knowledge of the variation of physiological responses in pathogen strains. Scientific pathogen inactivation data are crucial in food production to ensure food safety, and an understanding of the genetic basis of this phenotypic variation will result in a rational selection of target strains for process validations and improved processing, and more reliable risk assessments. At present the selection of thermal treatments rely on test strains for which data and clear relevance are missing. The hypothesis is based on preliminary data indicating considerable variation in response to processing stresses, even in closely related Salmonella variants. The project value is that scientific data that will be translated into recommendations for consumers, regulators and industry to ensure safe supply and consumption of trendy plant protein products.

本项目的目的是研究通过温和热处理组合灭活沙门氏菌的分子基础，并推荐关键限值，以确保病原体灭活和产品安全。我们将测试中心假设，即病原体菌株的遗传变异导致灭活的差异，特别是在温和的加热条件下，因此对食品安全和消费者健康的相关风险。这项研究的基本原理是，在病原体菌株的生理反应的变化的科学知识存在差距。科学的病原体灭活数据在食品生产中至关重要，以确保食品安全，了解这种表型变异的遗传基础将导致合理选择目标菌株进行工艺验证和改进加工，以及更可靠的风险评估。目前，热处理的选择依赖于测试菌株，其数据和明确的相关性缺失。这一假设是基于初步数据，表明相当大的变化，在响应加工应力，即使在密切相关的沙门氏菌变种。该项目的价值在于，科学数据将转化为消费者、监管机构和行业的建议，以确保安全供应和消费时尚的植物蛋白产品。