PRIDE: Functional and Translational Genomics of Blood Disorders

 描述（由申请人提供）：我们今天在医疗保健领域面临的最重要挑战之一是美国生物医学研究人员缺乏多样性。为了解决这个问题，2006年，国家心肺和血液研究所（NHLBI）资助了一个增加多样性的暑期研究所计划（SIPID）培训计划，后来又资助了一个增加健康相关研究中个体多样性的计划（PRIDE）。我们是这两个创新项目的创始成员，血液疾病夏季研究所的功能和应用基因组学目前在格鲁吉亚摄政大学（GRU）的最后一年。我们招募和培训了47名初级教师学员，他们接受了密集的指导，包括实验室研究和资助方面的实践培训。项目评估表明，这些暑期学院已经实现了帮助学员在项目完成后两年内获得校外资助的主要目标。更新后的GRU-PRIDE计划将保留以前计划的所有成功元素，同时对课程和指导活动进行了一些创新性的更改。在此更新期间，我们计划的目标将是授权36名学员通过密集的指导和动手实验台研究培训经验来开发具有竞争力的研究项目;该计划的成功将部分由每个学员的能力来衡量在计划完成后两年内获得校外资金。为了实现这一目标，我们提出了以下目标：AIM 1举办GRU骄傲1夏季研究所：实施GRU骄傲1夏季研究所，包括与协调核心合作建立个人导师委员会，将在该奖项的第一年开始。暑期研究所由多学科教学课程，动手长凳研究培训和赠款写作讲习班组成，以扩大学员在基因组学研究领域的知识基础，因为它适用于血液疾病。目标2指导和网络活动：除了继续我们的指导委员会，我们将实施两项创新：一个学员虚拟网络和一个同行网络实验室。学员将在年中访问导师的机构，以完善他们的研究项目，赠款写作技能，职业规划和板凳培训技巧。目的3进行骄傲2夏季研究所：学员将参加骄傲2夏季研究所提供额外的功能和翻译基因组学研究培训，并提高他们的赠款写作技能。每个学员将被要求提交赠款申请，以获得NHLBI赞助或其他校外资金。GRU-PRIDE计划课程和学员的成功将与国家协调核心合作进行持续评估。

 DESCRIPTION (provided by applicant): One of the most important challenges we face in healthcare today is a lack of diversity in the US biomedical research workforce. To address this issue, in 2006 the National Heart Lung and Blood Institute (NHLBI) funded a Summer Institute Program to Increase Diversity (SIPID) training program, and later the Program to Increase Diversity Among Individuals Engaged in Health-Related Research (PRIDE). We were founding members of both innovative programs, with the Functional and Applied Genomics of Blood Disorders Summer Institute currently in its last year at Georgia Regents University (GRU). We recruited and trained 47 junior faculty mentees who received intense mentoring, including hands-on training in bench research and grantsmanship. Program evaluations suggest these Summer Institutes have achieved their primary goal of aiding mentees in obtaining extramural grant funding within two years of program completion. The renewed GRU-PRIDE program will keep all of the successful elements of the previous program, while offering several innovative changes to the curriculum and mentoring activities. The goal of our program during this renewal will be to empower 36 mentees to develop a competitive research project through an intensive mentoring and hands-on bench research training experience; success of this program will be measured, in part, by the ability of each mentee to acquire extramural funding within two years following program completion. To reach this goal we propose the following aims: AIM 1 Conduct GRU PRIDE 1 Summer Institute: implementation of the GRU PRIDE 1 Summer Institute, including the establishment of individual Mentorship Committees in collaboration with the Coordination Core will begin during the first year of this award. The Summer Institute is composed of a multidisciplinary didactic curriculum, hands-on bench research training and a grant-writing workshop to expand the knowledge base of mentees in the field of genomics research as it applies to blood disorders. AIM 2 Mentoring and Networking Activity: In addition to the continuation of our Mentorship Committees, we will implement two innovations: a mentee virtual network and a peer- networking laboratory. Mentees will make a mid-year visit to the mentor's institution to refine their research project, grant-writing skills, career planning, and bench training techniques. AIM 3 Conduct PRIDE 2 Summer Institute: Mentees will participate in the PRIDE 2 Summer Institute to provide additional functional and translational genomics research training and to improve their grant-writing skills. Each mentee will be required to submit a grant application to acquire NHLBI-sponsored or other extramural funding. The GRU-PRIDE program curriculum and mentee success will be evaluated continuously in collaboration with the national Coordination Core.