PRIDE-Functional and Translational Genomics of Blood Disorders

PRIDE-血液疾病的功能和转化基因组学

• 批准号: 10557179
• 负责人: Betty Sue Pace
• 金额: $ 34.41万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-20 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10557179
• 关键词: 3-Dimensional; Achievement; Address; African American; Applications Grants; Award; Behavioral Sciences; Biomedical Research; Black race; Collaborations; Committee Members; Data; Development; Disabled Persons; Educational Curriculum; Educational process of instructing; Ethnic Population; Extramural Activities; Faculty; Fostering; Funding; Funding Mechanisms; Goals; Grant; Grant Review; Health; Hematological Disease; Home; Individual; Inequity; Institution; Investigator-Initiated Research; Leadership; Mentors; Mentorship; Monitor; National Heart, Lung, and Blood Institute; Obesity; Pilot Projects; Principal Investigator; Private Sector; Process; Program Evaluation; Protein Analysis; Public Sector; Reporting; Research; Research Personnel; Research Project Grants; Research Training; Resources; Scientist; Signal Recognition Particle; Teacher Professional Development; Technical Expertise; Testing; Texas; Training; Training Programs; Training Support; Underrepresented Minority; United States; United States National Institutes of Health; Universities; Visit; Writing; career; cohort; design; empowerment; experience; faculty mentor; functional genomics; hands-on learning; health disparity; improved; innovation; matriculation; meetings; member; multidisciplinary; novel; peer; programs; racial population; skills; statistics; success; summer institute; translational genomics

Abstract The lack of diversity remains a significant challenge in biomedical and behavioral science research programs and faculty composition in US academic centers. The National Heart, Lung, and Blood Institute (NHLBI) funded the Summer Institute Program to Increase Diversity (SIPID) in 2006. Subsequently, the Program to Increase Diversity Among Individuals Engaged in Health-Related Research-Functional and Translational Genomics of Blood Disorders (PRIDE-FTG) was established at Augusta University. Through the PRIDE-FTG program, we provided mentored training for 76 underrepresented minority junior faculty investigators. Mentees learned hands-on bench research and grantsmanship skills during two consecutive Summer Institutes. Program evaluation supports the achievement of our primary goal of aiding mentees to submit an NIH or equivalent grant application within two years of program completion, demonstrated by a 41.7% NIH grant-funding rate as principal investigator. We propose to continue this mentored training with the next iteration of PRIDE-FTG, expanded to include several innovative components and collaboration with the Obesity Health Disparities- PRIDE program to pool federal resources. We will test the hypothesis that a mentored training program to build research and grant-writing skills will increase the ability of URM and disabled faculty, conducting blood disorders research to obtain extramural funding and transition to independent research careers. Four aims will be accomplished: AIM 1. Conduct Innovative Summer Institute 1 at Augusta University (Component 1). Mentees matriculating into the PRIDE-FTG program will participate in a multidisciplinary curriculum including hands-on-bench research training and grant-writing activities to develop funding strategies. AIM 2. Support Small Research Project Funding Initiative (Component 4). In collaboration with the PRIDE Steering Committee and NHLBI program staff, the PRIDE-FTG program will fund focused pilot projects to support competitive grant proposals addressing blood disorders research. AIM 3. Facilitate Mentoring and Networking Activities (Component 2). Mentorship Committees comprised of a mentee, a PRIDE research mentor and home institution mentor will be established. Peer-mentorship teams will launch within cohorts to promote research collaboration. The program will support a mid-year visit to the mentor’s institution and attendance at the consortium-wide PRIDE annual meeting. AIM 4: Conduct Innovative Summer Institute 2 (Component 3). Mentees will return to Augusta University to complete a one-on-one grant review to meet the primary goal of the PRIDE program to submit an NIH or equivalent grant application and participate in additional research experiences. The mentored training supported by the PRIDE-FTG program will influence the number of underrepresented and disabled scientists achieving successful biomedical research careers.

抽象的 缺乏多样性仍然是生物医学和行为科学研究项目的重大挑战 以及美国学术中心的师资构成。国家心肺血液研究所 (NHLBI) 资助 2006 年，增加多样性夏季学院计划 (SIPID)。随后，增加多样性计划 从事健康相关研究的个体的多样性——功能和转化基因组学 血液疾病 (PRIDE-FTG) 在奥古斯塔大学成立。通过 PRIDE-FTG 计划，我们 为 76 名代表性不足的少数族裔初级教员调查员提供指导培训。学员学习了 在连续两个暑期学院期间获得实践台架研究和资助技能。程序 评估支持实现我们的主要目标，即帮助受训者提交 NIH 或同等学历 项目完成后两年内申请资助，NIH 资助率为 41.7% 首席研究员。我们建议在 PRIDE-FTG 的下一次迭代中继续这种指导培训， 扩展到包括几个创新成分以及与肥胖健康差异组织的合作- PRIDE 计划汇集联邦资源。我们将测试以下假设：建立指导培训计划 研究和资助写作技能将提高 URM 和残疾教师的能力， 疾病研究以获得校外资助并过渡到独立研究职业。四大目标将 要完成的目标： 目标 1. 在奥古斯塔大学举办创新暑期学院 1（第 1 部分）。 入读 PRIDE-FTG 计划的学员将参加多学科课程，包括 实践研究培训和资助写作活动，以制定资助策略。目标 2. 支持 小型研究项目资助计划（第 4 部分）。与 PRIDE 指导委员会合作 和 NHLBI 项目工作人员，PRIDE-FTG 项目将资助重点试点项目，以支持竞争性拨款 针对血液疾病研究的提案。目标 3. 促进指导和网络活动 （第 2 部分）。导师委员会由一名受训者、一名 PRIDE 研究导师和家庭成员组成 将设立机构导师。同伴指导团队将在队列中启动以促进研究 合作。该计划将支持年中访问导师所在机构并参加 联盟范围内的 PRIDE 年会。目标 4：开展创新暑期学院 2（第 3 部分）。 学员将返回奥古斯塔大学完成一对一的资助审查，以实现以下主要目标 PRIDE 计划提交 NIH 或同等资助申请并参与其他研究 经验。 PRIDE-FTG 计划支持的指导培训将影响 代表性不足和残疾的科学家取得了成功的生物医学研究生涯。