UNZA-VANDERBILT PARTNERSHIP FOR HIV-NUTRITION RESEARCH TRAINING (UVP)

描述(由申请者提供)：UNZA-Vanderbilt艾滋病毒-营养-代谢研究培训伙伴关系(UVP)将赞比亚大学医学院/大学教学医院(UNZA/UTH)与Vanderbilt大学及其全球卫生研究所(VIGH)长期合作的机构优势结合在一起。我们建议解决艾滋病毒和营养/新陈代谢相互作用这一复杂领域的研究培训需求。我们的使命是在营养和代谢相关的并发症和艾滋病毒的共病方面培训UNZA艾滋病毒研究负责人，同时扩大UNZA/UTH的临床研究培训和调查能力。抗逆转录病毒疗法(ART)的扩大已经将艾滋病毒变成了一种具有长期并发症的慢性疾病。营养因素是其中许多因素的核心，特别是在低收入国家，影响胃肠道、肾脏、神经系统和心血管系统的艾滋病毒致病过程。UNZA-Vanderbilt的合作发现了营养对抗逆转录病毒治疗结果的多种影响。UNZA已将博士级别的培训确定为在该机构内发展高级研究能力和学术领导能力的关键机制。UVP将为UNZA高级受训人员和初级教员提供临床研究方面的长期培训，从而获得由UNZA授予的10个“三明治”博士学位，并得到Vanderbilt研究导师和资源的支持。它将支持创新的多学科指导性论文研究，重点是与营养和代谢相关的艾滋病毒并发症和共病。UVP提案的特点是与AITRP建立了长达16年的合作伙伴关系，使41名赞比亚人获得了高级学位。自2009年以来，Vanderbilt内科教师一直在UNZA/UTH工作，极大地促进了许多美国赠款资助的教育和培训工作(AITRP、MEPI、ZEPACT、FICRS-F、Fogarty GHF)。一项大规模的艾滋病毒-营养临床试验(NuStart)正在建立一个大型的规范和数据存储库，学员可以在此基础上进行研究和设计长期的后续研究。UVP将通过举办国内咨询和教师发展研讨会来加强UNZA博士计划，以加强博士指导标准，开发实质性的方法学核心课程，并评估可衡量的里程碑。它将通过为期四个月的弗吉尼亚大学博士后休假为注重研究的UNZA教职员工提供职业发展机会，并扩大UNZA和Vanderbilt调查人员之间的临床研究合作，以吸引外部研究资金。我们将通过跟踪主要学员的产出，为我们的AITRP校友提供持续的技能培养机会，进行定期项目评估，并让我们的AITRP校友作为积极的国内教师参与我们在赞比亚的持续培训，来记录该项目的长期成功。UVP将加强UNZA培训未来研究人员的能力，吸引外部研究资金，并产生高影响力的研究成果。可持续性将通过未来导师的指导最大化。1

DESCRIPTION (provided by applicant): The UNZA-Vanderbilt Training Partnership for HIV-Nutrition-Metabolic Research (UVP) brings the University of Zambia School of Medicine/University Teaching Hospital (UNZA/UTH) together with the long- standing collaborating institutional strengths of Vanderbilt U. and its Institute for Global Health (VIGH). We pro- pose to address research training needs in the complex area of HIV and nutrition/metabolism interactions. Our mission is to train UNZA HIV research leaders in nutritionally- and metabolically-related complications and comorbidities of HIV, while expanding UNZA/UTH's clinical research training and investigative capacities. Antiretroviral therapy (ART) scale-up has turned HIV into a chronic condition with long-term complications. Nutritional factors are central to many of these, especially in low-income countries, affecting HIV pathogenic processes in the gastrointestinal tract, kidneys, nervous system, and cardiovascular system. UNZA-Vanderbilt collaborations have discovered multiple nutritional influences on ART outcomes. UNZA has identified PhD-level training as a key mechanism for developing advanced research capacity and academic leadership within the institution. UVP will provide long-term training in clinical investigation for advanced UNZA trainees and junior faculty members, leading to 10 "sandwich" PhD degrees awarded by UNZA and undergirded by Vanderbilt research mentorship and resources. It will support innovative multidisciplinary mentored disserta- tion research focused on nutritionally- and metabolically-related complications and comorbidities of HIV. The UVP proposal is distinguished by a 16-year AITRP partnership that has enabled 41 Zambians to obtain advanced degrees. A Vanderbilt Internal Medicine faculty member has been embedded at UNZA/UTH since 2009, substantially facilitating many US grant-funded education and training efforts (AITRP, MEPI, ZEPACT, FICRS-F, Fogarty GHF). A large-scale HIV-nutrition clinical trial (NUSTART) is building a large spec- imen and data repository on which trainees can base research and design long-term follow-up studies. UVP will strengthen the UNZA PhD Program by conducting in-country consultations and faculty devel- opment workshops to strengthen PhD mentoring standards, develop substantial methodological core courses, and assess measureable milestones. It will provide career development opportunities for research-focused UNZA faculty members via four-month VU-based postdoctoral sabbaticals, and expand clinical research col- laborations between UNZA and Vanderbilt investigators, to attract extramural research funding. We will document the program's long-term success by tracking major trainee outputs; providing ongoing skill-building opportunities for our AITRP alumni; conducting regular program evaluations; and engaging our AITRP alumni as active in-country instructors in our ongoing Zambia-based training. UVP will strengthen UNZA's capacity to train future researchers, attract extramural research funding, and generate high- impact research outputs. Sustainability will be maximized through the mentoring of future mentors. 1