UNZA-VANDERBILT PARTNERSHIP FOR HIV-NUTRITION RESEARCH TRAINING (UVP)

UNZA-范德比尔特艾滋病毒营养研究培训合作伙伴关系 (UVP)

• 批准号: 9313359
• 负责人: DOUGLAS CORBETT HEIMBURGER
• 金额: $ 30.2万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9313359
• 关键词: Affect; African; Aging; Award; Cardiovascular system; Caring; Chronic; Clinical Nutrition; Clinical Trials; Collaborations; Comorbidity; Consultations; Country; Databases; Doctor of Philosophy; Educational workshop; Epidemiology; Extramural Activities; Faculty; Follow-Up Studies; Funding; Future; Gastrointestinal tract structure; Grant; HIV; Institutes; Kidney; Leadership; Life Style; Measures; Mentors; Mentorship; Metabolic; Nervous system structure; Nutritional; Nutritional Study; Output; Pathogenicity; Process; Program Evaluation; Research; Research Personnel; Research Training; Resources; SERPINI2 gene; Specimen; Teacher Professional Development; Teaching Hospitals; Training; Training Support; Training and Education; Universities; Zambia; antiretroviral therapy; base; career development; course development; global health; innovation; instructor; low income country; medical schools; member; multidisciplinary; nutrition; programs; sabbatical; skills; success; therapy outcome

 DESCRIPTION (provided by applicant): The UNZA-Vanderbilt Training Partnership for HIV-Nutrition-Metabolic Research (UVP) continues a longstanding training collaboration of the University of Zambia School of Medicine/University Teaching Hospital (UNZA/UTH) and Vanderbilt University (VU) and its Institute for Global Health (VIGH). With PEPFAR's successes turning HIV into a chronic condition, many Africans are living full lives with HIV, but they are facing non-communicable diseases that come with lifelong antiretroviral therapy (ART), lifestyle changes accompany- ing the epidemiologic transition, and aging. Nutritional factors are central to many of these, especially in low- income countries, affecting pathogenic processes in the gastrointestinal tract, kidneys, nervous system, and cardiovascular system. UNZA-VIGH collaborations have discovered multiple nutritional influences on ART outcomes. A recently completed large-scale HIV-nutrition clinical trial (NUSTART) has built large specimen and data repositories that are available for analyses and long-term follow-up studies. UNZA has identified PhD training as crucial for advancing its institutional research capacity and academic leadership. UVP will support this by training UNZA PhD-level HIV research leaders in nutritionally- and metabolically related complications and comorbidities of HIV, while expanding UNZA/UTH's research training and investigative capacities. UVP will provide long-term research training for advanced UNZA trainees and junior faculty members, leading to 11 "sandwich" PhD degrees awarded by UNZA and undergirded by Vanderbilt didactic courses, research mentorship, and institutional resources. It will support innovative multidisciplinary mentored dissertation research focused on the key metabolic and nutritional challenges in long-term HIV care. The UVP proposal is distinguished by a 17-year AITRP partnership that has enabled 41 Zambians to obtain advanced degrees (mainly Master's) and has substantially facilitated many US grant-funded education and training efforts described within (AITRP, MEPI, ZEPACT, FICRS-F, Fogarty GHF). UVP will enhance the UNZA PhD Program by conducting in-country consultations, skill-building short courses, and faculty development workshops to strengthen PhD mentoring standards and assess measureable milestones. It will provide career development opportunities for research-focused UNZA faculty members via 4-month VU-based postdoctoral sabbaticals, to expand research collaborations between UNZA and VU investigators and to attract extramural research funding. We will document the program's long-term success by tracking major trainee outputs; providing ongoing skill-building opportunities for our AITRP alumni; conducting regular program evaluations; and engaging our AITRP alumni as active in-country instructors in ongoing Zam- bia-based trainings. UVP will strengthen UNZA's capacity to train future researchers, attract extramural research funding, and generate high-impact research outputs in a vital HIV research arena. Sustainabil- ity will be maximized by mentoring future mentors within all UVP activities.

 描述（由申请人提供）：UNZA-范德比尔特艾滋病毒营养代谢研究培训合作伙伴关系 (UVP) 继续与赞比亚大学医学院/大学教学医院 (UNZA/UTH) 和范德比尔特大学 (VU) 及其全球健康研究所 (VIGH) 之间的长期培训合作。随着总统防治艾滋病紧急援助计划（PEPFAR）成功将艾滋病毒转变为慢性病，许多非洲人在感染艾滋病毒后过着充实的生活，但他们面临着终身抗逆转录病毒治疗（ART）、伴随流行病学转变的生活方式改变和老龄化带来的非传染性疾病。营养因素是其中许多因素的核心，特别是在低收入国家，影响胃肠道、肾脏、神经系统和心血管系统的致病过程。 UNZA-VIGH 合作发现了营养对 ART 结果的多种影响。最近完成的一项大规模艾滋病毒营养临床试验（NUSTART）已经建立了大型样本和数据存储库，可用于分析和长期后续研究。 UNZA 认为博士培训对于提高其机构研究能力和学术领导力至关重要。 UVP 将通过培训 UNZA 博士级艾滋病毒研究领导者进行营养和代谢相关的艾滋病毒并发症和合并症方面的培训，同时扩大 UNZA/UTH 的研究培训和调查能力来支持这一目标。 UVP 将为高级 UNZA 学员和初级教员提供长期研究培训，从而获得 UNZA 颁发的 11 个“三明治”博士学位，并得到范德比尔特大学教学课程、研究指导和机构资源的支持。它将支持创新的多学科指导论文研究，重点关注长期艾滋病毒护理中的关键代谢和营养挑战。 UVP 提案以长达 17 年的 AITRP 伙伴关系为特色，该伙伴关系使 41 名赞比亚人获得了高级学位（主要是硕士学位），并极大地促进了许多美国赠款资助的教育和培训工作（AITRP、MEPI、ZEPACT、FICRS-F、Fogarty GHF）。 UVP将通过开展国内咨询、技能建设短期课程和教师发展研讨会来加强UNZA博士项目，以加强博士指导标准并评估可衡量的里程碑。它将通过为期 4 个月的 VU 博士后休假，为专注于研究的 UNZA 教员提供职业发展机会，以扩大 UNZA 和 VU 研究人员之间的研究合作，并吸引校外研究资金。我们将通过跟踪主要学员的产出来记录该计划的长期成功；为我们的 AITRP 校友提供持续的技能培养机会；定期进行计划评估；并让我们的 AITRP 校友作为活跃的国内讲师参与正在进行的赞比亚培训。 UVP 将加强 UNZA 培训未来研究人员、吸引校外研究资金以及在重要的艾滋病毒研究领域产生高影响力研究成果的能力。通过在 UVP 的所有活动中指导未来的导师，可以最大限度地提高可持续性。