UNZA-VANDERBILT PARTNERSHIP FOR HIV-NUTRITION RESEARCH TRAINING (UVP)-HIV supplement

 描述(由申请人提供)：联合国艾滋病毒-营养-新陈代谢研究培训伙伴关系(UVP)继续赞比亚大学医学院/大学教学医院(UNZA/UTH)和范德比尔特大学(VU)及其全球卫生研究所(VIGH)之间的长期培训合作。随着PEPFAR将艾滋病毒转变为慢性病的成功，许多非洲人正过着艾滋病毒携带者的完整生活，但他们面临着非传染性疾病，这些疾病伴随着终身抗逆转录病毒治疗(ART)、伴随着流行病学转变而改变的生活方式以及老龄化。营养因素是其中许多疾病的核心，特别是在低收入国家，影响胃肠道、肾脏、神经系统和心血管系统的致病过程。UNZA-VIGH合作发现营养对抗逆转录病毒治疗结果有多种影响。最近完成的一项大规模艾滋病毒-营养临床试验(NuStart)建立了可用于分析和长期跟踪研究的大型标本和数据存储库。UNZA已将博士培训确定为提高其机构研究能力和学术领导力的关键。UVP将通过培训UNZA博士级别的艾滋病毒研究负责人有关与营养和代谢有关的并发症和艾滋病毒的共病来支持这一点，同时扩大UNZA/UTH的研究培训和调查能力。UVP将为UNZA高级受训人员和初级教员提供长期研究培训，从而获得UNZA授予的11个“三明治”博士学位，并得到范德比尔特教学课程、研究指导和机构资源的支持。它将支持创新的多学科导师论文研究，重点是长期艾滋病毒护理中的关键新陈代谢和营养挑战。UVP提案的特点是与AITRP建立了17年的合作伙伴关系，使41名赞比亚人获得了高级学位(主要是硕士学位)，并极大地促进了美国资助的许多教育和培训工作(AITRP、MEPI、ZEPACT、FICRS-F、Fogarty GHF)。UVP将通过举办国内咨询、技能建设短期课程和教师发展研讨会来加强UNZA博士计划，以加强博士指导标准和评估可衡量的里程碑。它将通过为期4个月的弗吉尼亚大学博士后休假，为注重研究的UNZA教员提供职业发展机会，扩大UNZA和弗吉尼亚大学调查人员之间的研究合作，并吸引外部研究资金。我们将通过跟踪主要学员的产出，为我们的AITRP校友提供持续的技能培养机会，进行定期的项目评估，并让我们的AITRP校友作为活跃的国内教员参与基于ZAM-BIA的持续培训，来记录该计划的长期成功。UVP将加强UNZA培训未来研究人员的能力，吸引外部研究资金，并在至关重要的艾滋病毒研究领域产生高影响力的研究成果。通过在所有UVP活动中指导未来的导师，将使可持续性最大化。

 DESCRIPTION (provided by applicant): The UNZA-Vanderbilt Training Partnership for HIV-Nutrition-Metabolic Research (UVP) continues a longstanding training collaboration of the University of Zambia School of Medicine/University Teaching Hospital (UNZA/UTH) and Vanderbilt University (VU) and its Institute for Global Health (VIGH). With PEPFAR's successes turning HIV into a chronic condition, many Africans are living full lives with HIV, but they are facing non-communicable diseases that come with lifelong antiretroviral therapy (ART), lifestyle changes accompany- ing the epidemiologic transition, and aging. Nutritional factors are central to many of these, especially in low- income countries, affecting pathogenic processes in the gastrointestinal tract, kidneys, nervous system, and cardiovascular system. UNZA-VIGH collaborations have discovered multiple nutritional influences on ART outcomes. A recently completed large-scale HIV-nutrition clinical trial (NUSTART) has built large specimen and data repositories that are available for analyses and long-term follow-up studies. UNZA has identified PhD training as crucial for advancing its institutional research capacity and academic leadership. UVP will support this by training UNZA PhD-level HIV research leaders in nutritionally- and metabolically related complications and comorbidities of HIV, while expanding UNZA/UTH's research training and investigative capacities. UVP will provide long-term research training for advanced UNZA trainees and junior faculty members, leading to 11 "sandwich" PhD degrees awarded by UNZA and undergirded by Vanderbilt didactic courses, research mentorship, and institutional resources. It will support innovative multidisciplinary mentored dissertation research focused on the key metabolic and nutritional challenges in long-term HIV care. The UVP proposal is distinguished by a 17-year AITRP partnership that has enabled 41 Zambians to obtain advanced degrees (mainly Master's) and has substantially facilitated many US grant-funded education and training efforts described within (AITRP, MEPI, ZEPACT, FICRS-F, Fogarty GHF). UVP will enhance the UNZA PhD Program by conducting in-country consultations, skill-building short courses, and faculty development workshops to strengthen PhD mentoring standards and assess measureable milestones. It will provide career development opportunities for research-focused UNZA faculty members via 4-month VU-based postdoctoral sabbaticals, to expand research collaborations between UNZA and VU investigators and to attract extramural research funding. We will document the program's long-term success by tracking major trainee outputs; providing ongoing skill-building opportunities for our AITRP alumni; conducting regular program evaluations; and engaging our AITRP alumni as active in-country instructors in ongoing Zam- bia-based trainings. UVP will strengthen UNZA's capacity to train future researchers, attract extramural research funding, and generate high-impact research outputs in a vital HIV research arena. Sustainabil- ity will be maximized by mentoring future mentors within all UVP activities.