UNZA-VANDERBILT PARTNERSHIP FOR HIV-NUTRITION RESEARCH TRAINING (UVP)-HIV supplement

 描述（由申请人提供）：UNZA-范德比尔特艾滋病毒营养代谢研究（UVP）培训伙伴关系继续赞比亚大学医学院/大学教学医院（UNZA/UTH）和范德比尔特大学（VU）及其全球卫生研究所（VIGH）的长期培训合作。随着PEPFAR成功地将艾滋病毒转变为慢性病，许多非洲人正在与艾滋病毒一起生活，但他们面临着终身抗逆转录病毒治疗（ART）带来的非传染性疾病，伴随流行病转变的生活方式改变以及老龄化。营养因素是其中许多疾病的核心，特别是在低收入国家，影响胃肠道、肾脏、神经系统和心血管系统的致病过程。UNZA-VIGH合作发现了多种营养对ART结果的影响。最近完成的一项大规模艾滋病毒营养临床试验（NUSTART）建立了大型标本和数据库，可用于分析和长期随访研究。 UNZA已确定博士培训对于提高其机构研究能力和学术领导力至关重要。艾滋病毒研究所将支持这项工作，在营养和代谢相关的艾滋病毒并发症和合并症方面培训非洲艾滋病毒研究所的博士级艾滋病毒研究领导人，同时扩大非洲艾滋病毒研究所/坦桑尼亚联合共和国的研究培训和调查能力。UVP将为UNZA高级学员和初级教员提供长期的研究培训，最终获得UNZA颁发的11个“三明治”博士学位，并得到范德比尔特教学课程、研究指导和机构资源的支持。它将支持创新的多学科指导论文研究，重点是长期艾滋病毒护理中的关键代谢和营养挑战。UVP提案的特点是与AITRP建立了17年的伙伴关系，使41名赞比亚人获得了高级学位（主要是硕士学位），并大大促进了许多美国赠款资助的教育和培训工作（AITRP，MEPI，ZEPACT，FICRS-F，Fogarty GHF）。 UVP将通过开展国内咨询，技能建设短期课程和教师发展研讨会来加强UNZA博士课程，以加强博士指导标准并评估可衡量的里程碑。它将通过4个月的VU博士后休假为以研究为重点的UNZA教职员工提供职业发展机会，以扩大UNZA和VU调查员之间的研究合作，并吸引校外研究资金。我们将通过跟踪主要学员的产出来记录该计划的长期成功;为我们的AITRP校友提供持续的技能培养机会;进行定期的计划评估;并让我们的AITRP校友作为活跃的国内讲师参与正在进行的扎姆-基于偏见的培训。该项目将加强UNZA培训未来研究人员的能力，吸引校外研究资金，并在重要的艾滋病毒研究竞技场产生高影响力的研究成果。通过在所有UVP活动中指导未来的导师，将可持续性最大化。

 DESCRIPTION (provided by applicant): The UNZA-Vanderbilt Training Partnership for HIV-Nutrition-Metabolic Research (UVP) continues a longstanding training collaboration of the University of Zambia School of Medicine/University Teaching Hospital (UNZA/UTH) and Vanderbilt University (VU) and its Institute for Global Health (VIGH). With PEPFAR's successes turning HIV into a chronic condition, many Africans are living full lives with HIV, but they are facing non-communicable diseases that come with lifelong antiretroviral therapy (ART), lifestyle changes accompany- ing the epidemiologic transition, and aging. Nutritional factors are central to many of these, especially in low- income countries, affecting pathogenic processes in the gastrointestinal tract, kidneys, nervous system, and cardiovascular system. UNZA-VIGH collaborations have discovered multiple nutritional influences on ART outcomes. A recently completed large-scale HIV-nutrition clinical trial (NUSTART) has built large specimen and data repositories that are available for analyses and long-term follow-up studies. UNZA has identified PhD training as crucial for advancing its institutional research capacity and academic leadership. UVP will support this by training UNZA PhD-level HIV research leaders in nutritionally- and metabolically related complications and comorbidities of HIV, while expanding UNZA/UTH's research training and investigative capacities. UVP will provide long-term research training for advanced UNZA trainees and junior faculty members, leading to 11 "sandwich" PhD degrees awarded by UNZA and undergirded by Vanderbilt didactic courses, research mentorship, and institutional resources. It will support innovative multidisciplinary mentored dissertation research focused on the key metabolic and nutritional challenges in long-term HIV care. The UVP proposal is distinguished by a 17-year AITRP partnership that has enabled 41 Zambians to obtain advanced degrees (mainly Master's) and has substantially facilitated many US grant-funded education and training efforts described within (AITRP, MEPI, ZEPACT, FICRS-F, Fogarty GHF). UVP will enhance the UNZA PhD Program by conducting in-country consultations, skill-building short courses, and faculty development workshops to strengthen PhD mentoring standards and assess measureable milestones. It will provide career development opportunities for research-focused UNZA faculty members via 4-month VU-based postdoctoral sabbaticals, to expand research collaborations between UNZA and VU investigators and to attract extramural research funding. We will document the program's long-term success by tracking major trainee outputs; providing ongoing skill-building opportunities for our AITRP alumni; conducting regular program evaluations; and engaging our AITRP alumni as active in-country instructors in ongoing Zam- bia-based trainings. UVP will strengthen UNZA's capacity to train future researchers, attract extramural research funding, and generate high-impact research outputs in a vital HIV research arena. Sustainabil- ity will be maximized by mentoring future mentors within all UVP activities.