Novel Nanorods for High Efficiency Medical Imaging Applications

用于高效医学成像应用的新型纳米棒

• 批准号: 8692559
• 负责人: Christopher J. Summers
• 金额: $ 46.8万
• 依托单位: PHOSPHORTECH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8692559
• 关键词: Area; Communities; Crystallography; Detection; Development; Devices; Diagnostic radiologic examination; Digital Radiography; Electronics; Encapsulated; Ensure; Exhibits; Film; Goals; Growth; Image; Length; Light; Mammography; Medical; Medical Imaging; Methods; Molecular Biology; Nanostructures; Optics; Performance; Phase; Polymers; Positron-Emission Tomography; Powder dose form; Preparation; Process; Production; Property; Proteins; Quantum Dots; Radiation; Radiation Monitoring; Reaction Time; Relative (related person); Research; Resolution; Roentgen Rays; Shapes; Small Business Innovation Research Grant; Solutions; Structure; System; Techniques; Testing; Time; United States National Institutes of Health; Visible Radiation; X-Ray Crystallography; absorption; arm; base; bioimaging; commercialization; cost; density; improved; interest; light emission; meetings; monitoring device; nano; nanocomposite; nanocrystal; nanomaterials; nanometer; nanorod; nanosecond; nanostructured; novel; particle; process optimization; public health relevance; response; retinal rods; scale up; screening; self assembly; sensor; simulation; success; tomography

DESCRIPTION (provided by applicant): This Phase II SBIR proposal aims at the continued development and commercialization of a new class of high-performance X-ray imaging screens based on the recently developed core/shell nanorod (NR) and nano-tetrapods (NTs) structures. These multi-dimensional nanocrystalline (NC) structures can be easily embedded with high densities in transparent polymer matrices. They will have wide ranging applications in digital radiography, mammography, tomography, protein crystallography, as well as a various large-area radiation imaging and detection applications, never before possible using conventional scintillators. The goals of Phase I were successfully achieved and we have demonstrated the potential for high spatial resolution, very fast time response, no afterglow, no self-absorption, and good X-ray conversion efficiency. The nano- composite scintillators were prepared and tested independently by both PhosphorTech and Radiation Monitoring Devices (RMD) and have outperformed conventional organic and inorganic bulk scintillators on several fronts. During Phase II, our plan is to continue refining these NC structures and related screening/growth techniques and demonstrate their ability to outperform even single crystal X-ray scintillators in terms of resolution, detection area, gain, and production cost. This will be achieved by creating NCs with optimal lengths and narrow size distribution and then incorporating them into polymer composites containing orderly arrangement of such structures at high packing densities. The orderly NC arrangement, which will be achieved by well-established low-cost solution-based self-assembly techniques, will dramatically enhance X-ray absorption and facilitate light channeling through the polymer matrix to the electronic sensors. Using such methods, it is possible to attain very long (tens of microns) vertically aligned NCs in a polymer matrix with inter- NC spacings (that can act as light channels) of only few nanometers, as opposed to the micron spacing limitations provided by conventional CsI and other single crystal (or bulk powder) scintillating structures. The low-cost solution processing methods employed in these systems will also enable both large-area and high resolution scintillators with significant cost reduction compared to conventional bulk and single crystal materials. In summary, these novel NC-based films will have significant applications in various types of radiation detection devices, and other biomedical imaging applications, enhancing their value to the NIH and to the molecular biology and medical communities as a whole.

描述（由申请人提供）：该第二阶段SBIR提案旨在基于最近开发的核/壳纳米棒（NR）和纳米四脚体（NT）结构继续开发和商业化一类新的高性能X射线成像屏幕。这些多维纳米晶（NC）结构可以很容易地以高密度嵌入透明聚合物基体中。它们将在数字X射线摄影、乳房X射线摄影、断层扫描、蛋白质晶体学以及各种大面积辐射成像和检测应用中具有广泛的应用，这在使用传统闪烁器之前是不可能的。第一阶段的目标已经成功实现，我们已经证明了高空间分辨率，非常快的时间响应，没有余辉，没有自吸收，以及良好的X射线转换效率的潜力。该纳米复合材料澄清剂由PhosphorTech和辐射监测设备（RMD）独立制备和测试，并在几个方面优于传统的有机和无机散装澄清剂。 在第二阶段，我们的计划是继续完善这些NC结构和相关的筛选/生长技术，并证明其在分辨率，检测面积，增益和生产成本方面优于单晶X射线衍射仪的能力。这将通过产生具有最佳长度和窄尺寸分布的NC，然后将它们掺入含有以高填充密度有序排列的这种结构的聚合物复合材料中来实现。有序的NC排列将通过成熟的低成本基于溶液的自组装技术来实现，将显著增强X射线吸收，并促进光通过聚合物基质到达电子传感器。使用这样的方法，可以在聚合物基质中获得非常长（数十微米）的垂直排列的NC，其中NC间距（其可以充当光通道）仅为几纳米，这与常规CsI和其他单晶（或块状粉末）结晶结构提供的微米间距限制相反。在这些系统中采用的低成本溶液处理方法还将使大面积和高分辨率的晶体管与传统的块体和单晶材料相比具有显著的成本降低。总之，这些新型NC基薄膜将在各种类型的辐射检测设备和其他生物医学成像应用中具有重要的应用，从而提高其对NIH以及整个分子生物学和医学界的价值。

项目成果

Low-temperature hydrothermally grown 100 μm vertically well-aligned ultralong and ultradense ZnO nanorod arrays with improved PL property.

• DOI: 10.1016/j.jallcom.2017.01.273
• 发表时间: 2017-04-25
• 期刊: Journal of alloys and compounds
• 影响因子: 6.2
• 作者: Kurudirek SV;Pradel KC;Summers CJ
• 通讯作者: Summers CJ