Nanocrystalline Phosphors for Medical Imaging Applications

用于医学成像应用的纳米晶荧光粉

• 批准号: 7746911
• 负责人: Christopher J. Summers
• 金额: $ 15.74万
• 依托单位: PHOSPHORTECH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2010-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7746911
• 关键词: Arts; Characteristics; Chemicals; Collaborations; Communities; Crystallography; Diagnostic radiologic examination; Digital Radiography; Ensure; Europe; Exhibits; Film; Goals; Image; Light; Lighting; Mammography; Marketing; Medical; Medical Imaging; Molecular Biology; Particle Size; Performance; Phase; Polymers; Proteins; Quantum Dots; Reaction Time; Relative (related person); Resolution; Roentgen Rays; Sales; Screening procedure; Synchrotrons; System; Techniques; Testing; Time; United States National Institutes of Health; Visible Radiation; Work; absorption; base; beamline; bioimaging; detector; experience; gadolinium sulfoxylate; light emission; nano; nanocomposite; nanocrystal; nanoscale; nanosecond; particle; public health relevance; research study; sensor; success

DESCRIPTION (provided by applicant): A new class of high-performance X-ray phosphor screens will be developed based on nanocrystal quantum dots (QDs), with applications to protein crystallography, digital radiography and mammography applications, as well as a host of other important imaging and lighting applications. The goal in this project is to maximize X-ray conversion efficiency, spatial resolution, and time response, which will minimize afterglow. Nano-composite phosphor screens will be tested in state-of- the-art crystallographic CCD detectors, and compared with "standard" micro-crystalline ZnSe:Cu,Cl and Gd2O2S:Tb phosphor screens. Although phosphor screens made from micron-sized phosphors are efficient, bright X-ray converters, their large particle size produces a great deal of scatter, which limits their spatial resolution. Preliminary theoretical and experimental studies show that quantum dot phosphors in a transparent polymer-matrix screen exhibit significantly higher spatial resolution than micron-sized phosphor particles. In addition, their pico- to nano-seconds decay times and low afterglow characteristics will ensure response times orders of magnitude faster than existing phosphors. Moreover, QD phosphors can be made from high-Z materials to increase X-ray absorption and their spectral characteristic tuned to match the spectral sensitivity of CCD sensors. Specifically in Phase I, we will prepare QD phosphors and related screening techniques, and quantify their X-ray photoluminescence performance. Success in Phase I will be proven if we can show that nanometer-sized crystalline phosphors are significantly better than existing micron-sized crystalline phosphors, in terms of spatial resolution and time resolution. In Phase II, we will develop the techniques to synthesize large quantities of high quality nanocrystals, and optimize large screen characteristics for protein crystallography and medical imaging CCD detectors. QD-based X-ray converting films will have significant applications in digital radiography, crystallography, mammography, and various other biomedical imaging applications, enhancing their value to the NIH and to the molecular biology and medical communities as a whole. Key Words: Xray phosphor, nano-phosphor, nanocrystals, quantum dots, protein crystallography, digital radiography, mammography, biomedical imaging. PUBLIC HEALTH RELEVANCE: The proposed nanocrystalline phosphor materials will have significant applications in digital radiography, crystallography, and various medical imaging applications, enhancing its value to the NIH and to the molecular biology and medical communities as a whole.

描述（由申请人提供）：将基于量子点（QD）开发新型高性能X射线荧光屏，应用于蛋白质晶体学、数字X射线照相术和乳房X射线照相术应用，以及许多其他重要的成像和照明应用。该项目的目标是最大限度地提高X射线转换效率，空间分辨率和时间响应，从而最大限度地减少余辉。纳米复合荧光屏将在最先进的晶体CCD探测器中进行测试，并与“标准”微晶ZnSe：Cu，Cl和Gd2O2S：Tb荧光屏进行比较。虽然由微米级荧光粉制成的荧光屏是高效、明亮的X射线转换器，但它们的大颗粒尺寸会产生大量散射，这限制了它们的空间分辨率。初步的理论和实验研究表明，在透明的聚合物基质屏幕中的量子点磷光体表现出显着更高的空间分辨率比微米尺寸的磷光体颗粒。此外，其皮科至纳秒的衰减时间和低余辉特性将确保响应时间比现有磷光体快几个数量级。此外，QD磷光体可以由高Z材料制成，以增加X射线吸收，并且其光谱特性被调谐以匹配CCD传感器的光谱灵敏度。具体来说，在第一阶段，我们将制备量子点荧光粉和相关的筛选技术，并量化其X射线光致发光性能。如果我们能够证明纳米尺寸的晶体磷光体在空间分辨率和时间分辨率方面明显优于现有的微米尺寸的晶体磷光体，那么第一阶段的成功将得到证明。在第二阶段，我们将开发合成大量高质量纳米晶体的技术，并优化蛋白质晶体学和医学成像CCD探测器的大屏幕特性。基于QD的X射线转换膜将在数字放射照相术、晶体照相术、乳房X射线照相术和各种其他生物医学成像应用中具有重要应用，从而提高其对NIH以及整个分子生物学和医学界的价值。关键词：X射线荧光粉，纳米荧光粉，纳米晶体，量子点，蛋白质晶体学，数字放射摄影，乳腺摄影，生物医学成像。公共卫生关系：所提出的纳米晶磷光体材料将在数字放射照相、晶体学和各种医学成像应用中具有重要应用，从而提高其对NIH以及整个分子生物学和医学界的价值。