MAPP Research Network Second Phase

MAPP研究网络二期

• 批准号: 8775612
• 负责人: Emeran A Mayer
• 金额: $ 90万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8775612
• 关键词: Abdomen; Address; Anxiety; Biological; Biological Factors; Biological Markers; Bladder; Brain; Brain imaging; Brain region; Chronic; Classification; Clinical; Clinical Management; Collaborations; Data; Data Set; Development; Diagnostic; Disease; Etiology; Face; Foundations; Frequencies; Fright; Functional disorder; Funding; Future; Goals; Hyperalgesia; ImProv; Increased frequency of micturition; Individual; Ingestion; Intervention; Lead; Measures; Metadata; Methods; Modeling; Molecular; Natural History; Observational Study; Outcome; Pain; Participant; Pathology; Patients; Pattern; Pelvic Floor Muscle; Pelvic floor structure; Peripheral; Phase; Phenotype; Procedures; Psychological Stress; Quality Control; Rattus; Reporting; Request for Proposals; Research; Risk Factors; Rodent Model; Role; Sampling; Scanning; Sensory; Site; Stimulus; Stress; Subgroup; Symptoms; Syndrome; System; Testing; Time; Translational Research; Urinary tract infection; Urination; Vertebral column; Water; Woman; Women' s Group; base; chronic pelvic pain; clinically relevant; insight; male; men; neuroimaging; novel; pre-clinical; prospective; public health relevance; repository; response; tool; urinary; urologic

DESCRIPTION (provided by applicant): The goal of the MAPP Research Network is to provide new insights into underlying etiology, natural history, and risk factors of UCPPS in order to provide a translational foundation to facilitate future clinical intervention efforts and improv clinical management of the syndromes. The UCLA MAPP-II proposal builds on the significant insights gained from MAPP-I studies into symptom patterns, UCPPS subtypes and various biomarkers, including brain signatures. In addition to be continued analysis of data sets generated in MAPP-I, it aims to identify factors associated with and predictive of symptom change, in both UCPPS subjects and in a rodent model. The UCLA proposal addresses these goals in four specific aims, all of which, if funded, are expected to be addressed collaboratively in transMAPP studies: Aim 1. To conduct a symptom pattern study across the MAPP Research Network which will form the backbone for Aims 2 and 3. Aim 2. To determine functional and structural brain correlates of patient subgroups, symptom fluctuations, and natural history. Aim 3. To develop and apply enhanced functional assessments for UCPPS, including assessment of endogenous pain modulation systems. Aim 4. To evaluate central mechanisms underlying symptom fluctuations, including stress mechanisms and related molecular brain changes in a rodent model of UCPPS. It is expected that the proposed studies will provide an unprecedented wealth of data, which will facilitate major breakthroughs in our understanding of UCPPS pathophysiology and identification of novel treatment approaches.

描述（由申请人提供）：MAPP 研究网络的目标是提供对 UCPPS 的潜在病因学、自然史和风险因素的新见解，以便为促进未来的临床干预工作和改进综合征的临床管理提供转化基础。 UCLA MAPP-II 提案建立在 MAPP-I 对症状模式、UCPS 亚型和各种生物标志物（包括大脑特征）研究中获得的重要见解的基础上。除了对 MAPP-I 中生成的数据集进行持续分析之外，它还旨在确定 UCPPS 受试者和啮齿动物模型中与症状变化相关的因素并预测症状变化。加州大学洛杉矶分校的提案通过四个具体目标来解决这些目标，所有这些目标如果获得资助，预计将在 transMAPP 研究中共同解决： 目标 1. 在 MAPP 研究网络中进行症状模式研究，这将构成目标 2 和 3 的支柱。 目标 2. 确定患者亚组、症状波动和自然史的功能和结构大脑相关性。目标 3. 开发和应用 UCPPS 的增强功能评估，包括内源性疼痛调节系统的评估。目标 4. 评估 UCPPS 啮齿动物模型中症状波动的中心机制，包括应激机制和相关的分子大脑变化。预计拟议的研究将提供前所未有的丰富数据，这将有助于我们对 UCPPS 病理生理学的理解和新治疗方法的识别取得重大突破。