MAPP Research Network Second Phase

MAPP研究网络二期

• 批准号: 8775612
• 负责人: Emeran A Mayer
• 金额: $ 90万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8775612
• 关键词: Abdomen; Address; Anxiety; Biological; Biological Factors; Biological Markers; Bladder; Brain; Brain imaging; Brain region; Chronic; Classification; Clinical; Clinical Management; Collaborations; Data; Data Set; Development; Diagnostic; Disease; Etiology; Face; Foundations; Frequencies; Fright; Functional disorder; Funding; Future; Goals; Hyperalgesia; ImProv; Increased frequency of micturition; Individual; Ingestion; Intervention; Lead; Measures; Metadata; Methods; Modeling; Molecular; Natural History; Observational Study; Outcome; Pain; Participant; Pathology; Patients; Pattern; Pelvic Floor Muscle; Pelvic floor structure; Peripheral; Phase; Phenotype; Procedures; Psychological Stress; Quality Control; Rattus; Reporting; Request for Proposals; Research; Risk Factors; Rodent Model; Role; Sampling; Scanning; Sensory; Site; Stimulus; Stress; Subgroup; Symptoms; Syndrome; System; Testing; Time; Translational Research; Urinary tract infection; Urination; Vertebral column; Water; Woman; Women' s Group; base; chronic pelvic pain; clinically relevant; insight; male; men; neuroimaging; novel; pre-clinical; prospective; public health relevance; repository; response; tool; urinary; urologic

DESCRIPTION (provided by applicant): The goal of the MAPP Research Network is to provide new insights into underlying etiology, natural history, and risk factors of UCPPS in order to provide a translational foundation to facilitate future clinical intervention efforts and improv clinical management of the syndromes. The UCLA MAPP-II proposal builds on the significant insights gained from MAPP-I studies into symptom patterns, UCPPS subtypes and various biomarkers, including brain signatures. In addition to be continued analysis of data sets generated in MAPP-I, it aims to identify factors associated with and predictive of symptom change, in both UCPPS subjects and in a rodent model. The UCLA proposal addresses these goals in four specific aims, all of which, if funded, are expected to be addressed collaboratively in transMAPP studies: Aim 1. To conduct a symptom pattern study across the MAPP Research Network which will form the backbone for Aims 2 and 3. Aim 2. To determine functional and structural brain correlates of patient subgroups, symptom fluctuations, and natural history. Aim 3. To develop and apply enhanced functional assessments for UCPPS, including assessment of endogenous pain modulation systems. Aim 4. To evaluate central mechanisms underlying symptom fluctuations, including stress mechanisms and related molecular brain changes in a rodent model of UCPPS. It is expected that the proposed studies will provide an unprecedented wealth of data, which will facilitate major breakthroughs in our understanding of UCPPS pathophysiology and identification of novel treatment approaches.

描述（由申请人提供）：MAPP研究网络的目标是为UCPP的潜在病因，自然历史和危险因素提供新的见解，以提供转化基础，以促进未来的临床干预工作和即兴综合症的临床管理。 UCLA MAPP-II提案建立在从MAPP-I研究中获得症状模式，UCPPS亚型和各种生物标志物（包括脑签名）的重要见解。除了对MAPP-I中产生的数据集进行持续分析外，它旨在确定UCPPS受试者和啮齿动物模型中与症状变化相关的因素和预测。加州大学洛杉矶分校的提案以四个具体目标解决了这些目标，所有这些目标都将在TransMapp研究中协作解决：目标1。在MAPP研究网络上进行症状模式研究，以构成目标2和AIM 2。目标2。以确定功能和结构性大脑的障碍，确定患者子组的功能和结构性大脑相关，并具有症状，自然效应和自然病史。目标3。为UCPPS开发和应用增强的功能评估，包括评估内源性疼痛调节系统。目标4。评估啮齿动物UCPPS模型中的压力机制和相关分子大脑的变化，包括压力机制和相关的分子大脑变化。预计拟议的研究将提供前所未有的数据，这将有助于我们对UCPPS病理生理学的理解和新型治疗方法的鉴定。