MAPP Research Network Second Phase

描述（由申请人提供）：MAPP研究网络的目标是为UCPPS的潜在病因、自然史和危险因素提供新的见解，以便为未来的临床干预工作提供转化基础，并改善综合征的临床管理。加州大学洛杉矶分校的MAPP-II提案建立在从MAPP-I研究中获得的关于症状模式、UCPPS亚型和各种生物标志物（包括大脑特征）的重要见解之上。除了继续分析MAPP-I中生成的数据集外，它的目的是在UCPPS受试者和啮齿动物模型中确定与症状变化相关的因素并预测其变化。加州大学洛杉矶分校的提案以四个具体目标来解决这些目标，如果得到资助，所有这些目标都有望在transMAPP研究中得到合作解决：目标1。在MAPP研究网络上进行症状模式研究，这将成为目标2和目标3的主干。目标2。确定患者亚组、症状波动和自然病史的脑功能和结构相关性。目标3。开发和应用增强的UCPPS功能评估，包括内源性疼痛调节系统的评估。目标4。评估UCPPS啮齿动物模型中症状波动的核心机制，包括应激机制和相关的脑分子变化。预计这些研究将提供前所未有的丰富数据，这将有助于我们对UCPPS病理生理学的理解取得重大突破，并确定新的治疗方法。

DESCRIPTION (provided by applicant): The goal of the MAPP Research Network is to provide new insights into underlying etiology, natural history, and risk factors of UCPPS in order to provide a translational foundation to facilitate future clinical intervention efforts and improv clinical management of the syndromes. The UCLA MAPP-II proposal builds on the significant insights gained from MAPP-I studies into symptom patterns, UCPPS subtypes and various biomarkers, including brain signatures. In addition to be continued analysis of data sets generated in MAPP-I, it aims to identify factors associated with and predictive of symptom change, in both UCPPS subjects and in a rodent model. The UCLA proposal addresses these goals in four specific aims, all of which, if funded, are expected to be addressed collaboratively in transMAPP studies: Aim 1. To conduct a symptom pattern study across the MAPP Research Network which will form the backbone for Aims 2 and 3. Aim 2. To determine functional and structural brain correlates of patient subgroups, symptom fluctuations, and natural history. Aim 3. To develop and apply enhanced functional assessments for UCPPS, including assessment of endogenous pain modulation systems. Aim 4. To evaluate central mechanisms underlying symptom fluctuations, including stress mechanisms and related molecular brain changes in a rodent model of UCPPS. It is expected that the proposed studies will provide an unprecedented wealth of data, which will facilitate major breakthroughs in our understanding of UCPPS pathophysiology and identification of novel treatment approaches.