MAPP Research Network Second Phase

描述(由申请人提供)：MAPP研究网络的目标是对UCPPS的潜在病因、自然病史和风险因素提供新的见解，以便提供翻译基础，促进未来的临床干预努力和改善综合征的临床管理。加州大学洛杉矶分校的MAPP-II提案建立在MAPP-I研究对症状模式、UCPPS亚型和包括大脑签名在内的各种生物标记物的重要见解的基础上。除了继续分析MAPP-I中产生的数据集外，它的目的是在UCPPS受试者和啮齿动物模型中识别与症状变化相关的因素和对症状变化的预测。加州大学洛杉矶分校的提案在四个具体目标中解决了这些目标，如果获得资金，所有这些目标都有望在跨MAPP研究中协同解决：目标1.在MAPP研究网络中进行症状模式研究，这将成为目标2和3的主干。目标2.确定患者亚组、症状波动和自然病史之间的功能和结构相关性。目的3.开发和应用增强的UCPPS功能评估，包括评估内源性疼痛调制系统。目的4.评价引起症状波动的中枢机制，包括应激机制和相关的分子脑变化。预计拟议的研究将提供前所未有的丰富数据，这将有助于我们在了解UCPPS的病理生理和确定新的治疗方法方面取得重大突破。

DESCRIPTION (provided by applicant): The goal of the MAPP Research Network is to provide new insights into underlying etiology, natural history, and risk factors of UCPPS in order to provide a translational foundation to facilitate future clinical intervention efforts and improv clinical management of the syndromes. The UCLA MAPP-II proposal builds on the significant insights gained from MAPP-I studies into symptom patterns, UCPPS subtypes and various biomarkers, including brain signatures. In addition to be continued analysis of data sets generated in MAPP-I, it aims to identify factors associated with and predictive of symptom change, in both UCPPS subjects and in a rodent model. The UCLA proposal addresses these goals in four specific aims, all of which, if funded, are expected to be addressed collaboratively in transMAPP studies: Aim 1. To conduct a symptom pattern study across the MAPP Research Network which will form the backbone for Aims 2 and 3. Aim 2. To determine functional and structural brain correlates of patient subgroups, symptom fluctuations, and natural history. Aim 3. To develop and apply enhanced functional assessments for UCPPS, including assessment of endogenous pain modulation systems. Aim 4. To evaluate central mechanisms underlying symptom fluctuations, including stress mechanisms and related molecular brain changes in a rodent model of UCPPS. It is expected that the proposed studies will provide an unprecedented wealth of data, which will facilitate major breakthroughs in our understanding of UCPPS pathophysiology and identification of novel treatment approaches.