Real-time Asthma and Air Pollution Project (Asthma APP)

实时哮喘与空气污染项目（哮喘APP）

• 批准号: 9077039
• 负责人: FRANK D. GILLILAND
• 金额: $ 214.69万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9077039
• 关键词: 12 year old; Accounting; Acute; Address; Adherence; Air Pollutants; Air Pollution; Asthma; Biomedical Research; Bronchitis; California; Caregivers; Caring; Cations; Cessation of life; Child; Child health care; Childhood; Childhood Asthma; Chronic; Chronic Disease; Clinic; Clinical; Clinical Management; Communities; Coughing; Data; Development; Emergency department visit; Ensure; Environment; Etiology; Evaluation; Event; Exposure to; Family; Feedback; Future; Goals; Health; Hospitalization; Individual; Indoor environment; Intervention; Longitudinal Studies; Los Angeles; Measurement; Measures; Medical; Morbidity - disease rate; Neighborhoods; Outcome; Ozone; Participant; Particulate Matter; Patients; Pattern; Performance; Pharmaceutical Preparations; Physicians; Physiological; Play; Pollen; Pollution; Prevention; Preventive Intervention; Process; Production; Protocols documentation; Psychosocial Factor; Public Health; Quality of life; Recommendation; Recording of previous events; Recruitment Activity; Research Personnel; Risk; Scientific Advances and Accomplishments; Self Management; Sleep; Societies; Stress; Symptoms; System; Testing; Time; Validity and Reliability; abstracting; ambient air pollution; asthmatic patient; base; cost; economic cost; improved; information display; mHealth; meetings; performance tests; personalized intervention; personalized medicine; predictive modeling; prototype; psychosocial; sensor; trafficking; usability

PROJECT 3 ABSTRACT (PROJECT DESCRIPTION) Asthma exacerbations lasting for weeks occur in 25-50% of children with asthma each year in Southern Califor- nia. Remarkably, ozone and particulate matter (PM) may account for as much as 70% of bronchitis-related ex- acerbations in the polluted communities studied in the landmark Children’s Health Study (CHS). Given the clinical and public health burden from asthma exacerbations, there is a clear need for improved prevention and clinical management approaches. The Los Angeles PRISMS Center will develop a system to advance the scientific understanding of asthma symptoms and exacerbations as well as deliver timely, personalized interventions and treatments to support self-management activities, promote adherence, and provide active feedback to patients, caregivers, clinicians, and researchers. In this U54 application, we propose to develop and test an integrated asthma management platform, the Bio- medical REAl-Time Health Evaluation for Pediatric Asthma (BREATHE). The broad objectives of Project 3 are to develop, assess performance, and test field protocols for the integrative BREATHE platform; to improve sci- entific understanding of asthma exacerbations; and to develop risk prediction models using real-time data on determinates of exacerbations. To meet these objectives, we propose the following specific aims for this appli- cation: 1) to evaluate field performance of the BREATHE platform in key microenvironments including accuracy and precision of highly resolved spatial and temporal data for exposure assessment, reliability and validity of asthma outcomes and psychosocial variables (e.g., stress); 2) to develop and test field protocols for use of BREATHE in longitudinal studies of 8-12 year old children with asthma, including potential PRISMS U01 sensors; 3) to assess usability of BREATHE for children with asthma and their caregivers, for clinicians, and for research- ers including iterative refinement of protocols and the user interfaces; 4) to increase scientific understanding of the contextual real-time determinants of asthma exacerbations; and 5) to enhance a risk prediction model by incorporating real-time contextual data and analytics to provide actionable information for personalized self- management and prevention of exacerbations among children with asthma. The participants for Project 3 will be recruited from the UCLA Pediatric Asthma Clinic. Efforts in Project 3 are thus closely coordinated with the tech- nical developments in Projects 1 & 2 to ensure a usable end-to-end platform. Our anticipated outcome is a well- characterized and operational prototype demonstrating BREATHE, with great potential for supporting PRISMS and future pediatric biomedical research.

项目3摘要（项目说明） 在南加州，每年有25-50%的哮喘儿童发生持续数周的哮喘恶化， nia。值得注意的是，臭氧和颗粒物（PM）可能占支气管炎相关疾病的70%。 在具有里程碑意义的儿童健康研究（CHS）中研究的污染社区中，鉴于临床 由于哮喘急性发作和公共卫生负担，显然需要改善预防和临床治疗， 管理方法。洛杉矶PRISMS中心将开发一个系统， 了解哮喘症状和急性发作，并提供及时、个性化的干预措施， 支持自我管理活动的治疗，促进依从性，并为患者提供积极的反馈， 护理人员、临床医生和研究人员。 在这个U 54应用程序中，我们建议开发和测试一个集成的哮喘管理平台，生物， 儿科哮喘医学实时健康评估（呼吸）。项目3的主要目标是 为一体化BREATHE平台开发、评估性能和测试现场协议;提高科学技术水平; 有效了解哮喘急性发作;并使用以下方面的实时数据开发风险预测模型： 确定加重。为了达到这些目标，我们建议这项申请的具体目标如下： 阳离子：1）评估BREATHE平台在关键微环境中的现场性能，包括准确性 高分辨率空间和时间数据的精确性， 哮喘结果和心理社会变量（例如，2）开发和测试现场协议，以使用 8-12岁哮喘儿童纵向研究中的呼吸，包括潜在的PRISMS U 01传感器; 3)评估呼吸对哮喘儿童及其护理人员、临床医生和研究的可用性- 包括协议和用户界面的迭代改进; 4）增加对 哮喘急性发作的背景实时决定因素;以及5）通过以下方式增强风险预测模型： 整合实时上下文数据和分析，为个性化的自助服务提供可操作的信息， 管理和预防儿童哮喘加重。项目3的参与者将是 从加州大学洛杉矶分校儿科哮喘诊所招募的因此，项目3的工作与技术密切协调， 项目1和2中的技术开发，以确保可用的端到端平台。我们的预期结果是- 展示BREATHE的特征化和操作原型，具有支持PRISMS的巨大潜力 以及未来的儿科生物医学研究。