Impact of preconception and onward exposure to air pollution on growth trajectories of infants and children (R01)
怀孕前和以后接触空气污染对婴儿和儿童生长轨迹的影响(R01)
基本信息
- 批准号:9817079
- 负责人:
- 金额:$ 52.14万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-03 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdolescenceAdultAffectAirAir PollutantsAir PollutionAlcohol consumptionAromatic Polycyclic HydrocarbonsBehavioralBirthBirth WeightBody WeightBreast FeedingCaloriesChildChildhoodChronic DiseaseConceptionsCongenital Heart DefectsConsumptionDataData SetDevelopmentDietEconomicsEnrollmentEnvironmental ExposureEpigenetic ProcessEthnic OriginExposure toFathersFetal GrowthFetusGametogenesisGeneticGerm CellsGestational AgeGestational DiabetesGovernmentGrowthHealthHeightHospitalsHumanHypertensionImpairmentIn VitroInfantInfant CareInfectionIntakeKnowledgeLeadLifeLongitudinal StudiesLongitudinal cohortLow Birth Weight InfantMaternal ExposureMeasurementMeasuresModelingMonitorMothersNeonatalNewborn InfantNitrogen DioxideObesityObesity EpidemicOutcomeParentsParticulate MatterPaternal ExposurePatternPhenotypePhysical activityPlacentaPollutionPolynomial ModelsPopulationPredispositionPregnancyProcessPublishingReportingResolutionRisk FactorsRoleSample SizeScheduleSiteSmokingSmoking StatusSpecific qualifier valueStatistical ModelsStudy SubjectTestingTimeTobacco smokeWeightWeight GainWomanadverse outcomeair monitoringbasecohortcritical developmental perioddietary supplementsearly childhoodearly life exposurefetal programmingfine particlesflexibilityglobal healthin uteroinfancyland usematernal cigarette smokingmenmetropolitanobesity developmentobesity in childrenobesity riskphysical conditioningpollutantpostnatalpostnatal periodprenatalprenatal exposureprogramsresidencesexsocialurban area
项目摘要
PROJECT SUMMARY/ABSTRACT
Childhood obesity is a risk factor for many chronic diseases in childhood and adulthood. Excessive calorie
consumption, inadequate physical activity, and genetics are important factors in the burgeoning obesity epidemic;
but emerging evidence suggests a role for early-life exposure to air pollution, beginning at the preconception
period of gametes maturation and continuing into the entire childhood. Despite that 92% of world’s population
today lives in places where ambient air quality exceeds health-based limits per a 2016 WHO report, no published
studies have assessed the potential critical time windows, including the preconception period, during which air
pollution exposures may adversely affect birth weight and growth trajectory, two significant predictors for
childhood obesity.
Here we present an overarching hypothesis that air pollution exposures during critical early
life developmental periods of preconception, in utero, and first 2 years of life, are associated with obesity-related
developmental perturbations, which is manifested by low birth weight and higher growth trajectories during early
childhood. We propose to examine this hypothesis in 20,000 newborns whose fathers and mothers have both
been enrolled in the Shanghai PreConception Cohort (SPCC) throughout 29 hospitals from year 2016-2018.
Each of these newborns has detailed paternal and maternal preconception baseline health, dietary supplement,
smoking, alcohol consumption, and demographic data, detailed maternal gestational information, and birth
outcome data. During their first 2 years of life, these newborns have up to 6 scheduled physical and health
exams, providing data for us to calculate weight and height, potentially non-linear, growth trajectories and assess
relevant postnatal variables such as breast-feeding, infection, and illness. Across the 20,000 residence
addresses of study subjects, there exist unusually large temporal and spatial variabilities in pollutant
concentrations especially for traffic related air pollutants. We will use cutting-edge tempo-spatial exposure
models, validated with air monitoring data from 10 governmental stations and our supplementary air pollution
measurements, to compute pollutant concentrations at residence addresses for a set of specified time windows
including sensitive preconception periods for mothers and fathers (respectively), gestational months and
trimesters, and throughout the first 2 years of infancy. By leveraging the rich dataset of this large longitudinal
cohort of 20,000 children,
we will use distributed lag models to identify critical exposure windows and to examine
potential effect differences by factors such as child sex, social economic status and parental smoking status
from preconception to gestation periods. If our hypothesis is proven true, this study will provide the first scientific
evidence supporting paternal and maternal air pollution exposure during critical time windows, including
preconception and in utero periods, as a risk factor for low birth weight and excessive body growth in childhood.
项目总结/摘要
儿童期肥胖是儿童期和成年期许多慢性疾病的危险因素。热量过多
消费、体育活动不足和遗传是肥胖症流行迅速发展的重要因素;
但新出现的证据表明,早期暴露于空气污染的作用,
配子成熟并持续到整个童年的时期。尽管世界上92%的人口
根据2016年世卫组织的一份报告,今天生活在环境空气质量超过健康限值的地方,
研究评估了潜在的关键时间窗口,包括孕前时期,在此期间,空气
污染暴露可能会对出生体重和生长轨迹产生不利影响,这是两个重要的预测因素,
儿童肥胖症
在这里,我们提出了一个总体假设,即空气污染暴露在关键的早期
孕前、子宫内和生命头2年的生命发育期与肥胖相关
发育障碍,表现为低出生体重和早期较高的生长轨迹
童年.我们建议在20,000名新生儿中检验这一假设,这些新生儿的父亲和母亲都有
2016-2018年,在29家医院入组上海孕前队列研究(SPCC)。
这些新生儿中的每一个都有详细的父亲和母亲孕前基线健康,膳食补充剂,
吸烟、饮酒和人口统计学数据,详细的孕产妇妊娠信息,以及出生
结果数据。在他们生命的前2年,这些新生儿有多达6个预定的身体和健康
考试,为我们提供数据来计算体重和身高,潜在的非线性,生长轨迹和评估
相关的产后变量,如母乳喂养,感染和疾病。在20,000个住宅中,
由于研究对象的不同,污染物的时空变异性异常大,
特别是与交通有关的空气污染物。我们将使用最先进的时空曝光技术
模型,用10个政府监测站的空气监测数据和我们的补充空气污染数据进行验证
测量,以计算一组指定时间窗内居住地址的污染物浓度
包括母亲和父亲(分别)的敏感孕前期、妊娠月数和
妊娠期和婴儿期的前两年。通过利用这一大型纵向数据库的丰富数据集,
两万名儿童组成的队列,
我们将使用分布式滞后模型来确定关键的暴露窗口,并检查
儿童性别、社会经济状况和父母吸烟状况等因素的潜在影响差异
从怀孕前到怀孕期。如果我们的假设被证明是正确的,这项研究将提供第一个科学的
在关键时间窗内,支持父亲和母亲空气污染暴露的证据,包括
怀孕前和子宫内时期,作为低出生体重和儿童期身体过度生长的风险因素。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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FRANK D. GILLILAND其他文献
FRANK D. GILLILAND的其他文献
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{{ truncateString('FRANK D. GILLILAND', 18)}}的其他基金
Impact of preconception and onward exposure to air pollution on growth trajectories of infants and children (R01)
怀孕前和以后接触空气污染对婴儿和儿童生长轨迹的影响(R01)
- 批准号:
10159920 - 财政年份:2019
- 资助金额:
$ 52.14万 - 项目类别:
Impact of preconception and onward exposure to air pollution on growth trajectories of infants and children (R01)
怀孕前和以后接触空气污染对婴儿和儿童生长轨迹的影响(R01)
- 批准号:
10006854 - 财政年份:2019
- 资助金额:
$ 52.14万 - 项目类别:
Impact of preconception and onward exposure to air pollution on growth trajectories of infants and children (R01)
怀孕前和以后接触空气污染对婴儿和儿童生长轨迹的影响(R01)
- 批准号:
10415058 - 财政年份:2019
- 资助金额:
$ 52.14万 - 项目类别:
Real-time Asthma and Air Pollution Project (Asthma APP)
实时哮喘与空气污染项目(哮喘APP)
- 批准号:
9077039 - 财政年份:2015
- 资助金额:
$ 52.14万 - 项目类别:
Project 1: Effects of Air Pollution on the Development of Obesity in Children
项目1:空气污染对儿童肥胖发展的影响
- 批准号:
8875809 - 财政年份:2014
- 资助金额:
$ 52.14万 - 项目类别:
INTEGRATIVE GENETIC APPROACHES TO GENE-AIR POLLUTION INTERACTIONS IN ASTHMA
哮喘中基因与空气污染相互作用的综合遗传方法
- 批准号:
8626197 - 财政年份:2012
- 资助金额:
$ 52.14万 - 项目类别:
Genes, Air Pollution, Oxidant Stress, Inflammation and Children's Resp
基因、空气污染、氧化应激、炎症和儿童呼吸
- 批准号:
8279266 - 财政年份:2011
- 资助金额:
$ 52.14万 - 项目类别:
Genes, Air Pollution, Oxidant Stress, Inflammation and Children's Resp
基因、空气污染、氧化应激、炎症和儿童呼吸
- 批准号:
8075551 - 财政年份:2010
- 资助金额:
$ 52.14万 - 项目类别:
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