Comparative Energetics and Aging
比较能量学和衰老
基本信息
- 批准号:8958637
- 负责人:
- 金额:$ 50.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-07-15 至 2020-06-30
- 项目状态:已结题
- 来源:
- 关键词:AgeAgingAging-Related ProcessAlabamaAllyAnimal ModelAnimalsAreaAssimilationsBioenergeticsBiological ModelsBiologyBiology of AgingBirdsBody CompositionBrown FatBudgetsCellsChronic DiseaseCollaborationsCommunitiesComparative BiologyComparative StudyComplementComplexCountryDataData SetDependenceDependencyDevelopmentDiseaseDistantEatingElderlyEnergy IntakeEnergy MetabolismEnvironmentExpenditureFishesFosteringGenesGeroscienceGoalsHealthHeartInstructionIntakeInvertebratesInvestigationLaboratoriesLifeLinkLongevityMammalsMetabolicMetabolismMethodologyMethodsMitochondriaMitochondrial DNAModelingMusNuclearNutrientObesityOrganellesOxidative StressPatternPhylogenetic AnalysisPopulationRegulationResearchResearch InfrastructureResearch PersonnelResistanceResourcesRodentSamplingServicesShockSignal TransductionSumTechniquesTechnologyTemperatureThinnessTissuesTraining SupportTraining and EducationTwin Multiple BirthUnited States National Institutes of HealthUniversitiesVariantYeastscohortcomparativedetection of nutrientenergy balanceflyindexinginnovationinstrumentationinterestmetabolomicsmitochondrial dysfunctionnew technologynovelprogramsresearch and developmentresearch study
项目摘要
DESCRIPTION (provided by applicant): The University of Alabama at Birmingham (UAB) proposes to establish a Nathan Shock Center of Excellence in the Basic Biology of Aging focused on comparative energetics and aging. Energetics is comprehensively defined for this purpose as the study of the causes, mechanisms, and consequences of the acquisition, storage, and utilization of metabolizable energy. Comparative energetics is the study of metabolic processes at multiple scales and across multiple species, in this case as it relates to health and aging. Nearly a century of aging research has reinforced the link between energetics and aging. In modern terms this link is reified as dysregulated mitochondrial function, metabolic signaling, and nutrient responsiveness. The twin objectives of the Center will be to (1) explore in
greater depth and detail than previously the complex relationship among cellular and organismal energetics and their relationship to health and aging, and (2) provide quantitative, state-of-the-art technologies and novel methodologies in the assessment and analysis of energetics to the basic aging research community at large. In pursuit of these objectives, we propose developing three research cores. First, the Comparative Organismal Energetics Core will provide expertise and cutting edge instruction and methodology for determining complete whole animal energy balance (intake, assimilation, expenditure) and body composition, including regional distribution of white and brown adipose tissue, in living animals of various species including flies, fish, mice
or other mammals, under any ambient temperature or activity regime. Second, the Comparative Mitochondrial Health Assessment Core will provide integrated, quantitative energetics analysis at the level of the organelle, cell, or tissue for both traditional and emerging animal models, including targeted metabolomics, assessment of mitophagy, and oxidative stress. Mitochondrial-nuclear exchange models are also available to enable experiments that evaluate the contribution of mtDNA variation to bioenergetics. Third, the Comparative Data Analytics Core will provide innovative analytic approaches to data sets linking comparative energetics to organismal health and longevity. With these research cores plus the administrative and research development core, we aim to: (i) facilitate hypothesis-driven research and leverage these technologies into new projects, interactions, and collaborations nationwide in basic aging research; (ii) foster meaningful novel interactions among investigators within UAB and across the region and country; and (iii) provide resources, education, training, and direction to junior investigators through the intellectual resources and research infrastructure, the Center will develop. In sum, these cores and the outstanding cohort of investigators assembled for this Center will provide unique expertise and novel collaborative opportunities for new and established investigators at UAB and beyond.
描述(由申请人提供):阿拉巴马大学伯明翰分校(UAB)提议建立一个专注于比较能量学和衰老基础生物学的Nathan Shock卓越中心。为此,能量学被全面定义为研究代谢能的获取、储存和利用的原因、机制和后果。比较能量学是研究多尺度和多物种的代谢过程,在这种情况下,它与健康和衰老有关。近一个世纪的衰老研究强化了能量学与衰老之间的联系。在现代术语中,这种联系被具体化为线粒体功能失调、代谢信号和营养反应。该中心的两个目标是:(1)探索
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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STEVEN N. AUSTAD其他文献
STEVEN N. AUSTAD的其他文献
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{{ truncateString('STEVEN N. AUSTAD', 18)}}的其他基金
A New Translational Rat Model for Evaluating Anti-Aging Interventions
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10665539 - 财政年份:2022
- 资助金额:
$ 50.69万 - 项目类别:
A New Translational Rat Model for Evaluating Anti-Aging Interventions
用于评估抗衰老干预措施的新转化大鼠模型
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10369517 - 财政年份:2022
- 资助金额:
$ 50.69万 - 项目类别:
A Four Core Genotype (FCG) Approach to Investigating Sex Differences in Health and Longevity
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9504206 - 财政年份:2018
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$ 50.69万 - 项目类别:
A sex difference approach to evaluating resilience as a predictor of healthspan in mice
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10166754 - 财政年份:2017
- 资助金额:
$ 50.69万 - 项目类别:
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