Comparative Energetics and Aging

比较能量学和衰老

• 批准号: 8958637
• 负责人: STEVEN N. AUSTAD
• 金额: $ 50.69万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8958637
• 关键词: Age; Aging; Aging-Related Process; Alabama; Ally; Animal Model; Animals; Area; Assimilations; Bioenergetics; Biological Models; Biology; Biology of Aging; Birds; Body Composition; Brown Fat; Budgets; Cells; Chronic Disease; Collaborations; Communities; Comparative Biology; Comparative Study; Complement; Complex; Country; Data; Data Set; Dependence; Dependency; Development; Disease; Distant; Eating; Elderly; Energy Intake; Energy Metabolism; Environment; Expenditure; Fishes; Fostering; Genes; Geroscience; Goals; Health; Heart; Instruction; Intake; Invertebrates; Investigation; Laboratories; Life; Link; Longevity; Mammals; Metabolic; Metabolism; Methodology; Methods; Mitochondria; Mitochondrial DNA; Modeling; Mus; Nuclear; Nutrient; Obesity; Organelles; Oxidative Stress; Pattern; Phylogenetic Analysis; Population; Regulation; Research; Research Infrastructure; Research Personnel; Resistance; Resources; Rodent; Sampling; Services; Shock; Signal Transduction; Sum; Techniques; Technology; Temperature; Thinness; Tissues; Training Support; Training and Education; Twin Multiple Birth; United States National Institutes of Health; Universities; Variant; Yeasts; cohort; comparative; detection of nutrient; energy balance; fly; indexing; innovation; instrumentation; interest; metabolomics; mitochondrial dysfunction; new technology; novel; programs; research and development; research study

DESCRIPTION (provided by applicant): The University of Alabama at Birmingham (UAB) proposes to establish a Nathan Shock Center of Excellence in the Basic Biology of Aging focused on comparative energetics and aging. Energetics is comprehensively defined for this purpose as the study of the causes, mechanisms, and consequences of the acquisition, storage, and utilization of metabolizable energy. Comparative energetics is the study of metabolic processes at multiple scales and across multiple species, in this case as it relates to health and aging. Nearly a century of aging research has reinforced the link between energetics and aging. In modern terms this link is reified as dysregulated mitochondrial function, metabolic signaling, and nutrient responsiveness. The twin objectives of the Center will be to (1) explore in greater depth and detail than previously the complex relationship among cellular and organismal energetics and their relationship to health and aging, and (2) provide quantitative, state-of-the-art technologies and novel methodologies in the assessment and analysis of energetics to the basic aging research community at large. In pursuit of these objectives, we propose developing three research cores. First, the Comparative Organismal Energetics Core will provide expertise and cutting edge instruction and methodology for determining complete whole animal energy balance (intake, assimilation, expenditure) and body composition, including regional distribution of white and brown adipose tissue, in living animals of various species including flies, fish, mice or other mammals, under any ambient temperature or activity regime. Second, the Comparative Mitochondrial Health Assessment Core will provide integrated, quantitative energetics analysis at the level of the organelle, cell, or tissue for both traditional and emerging animal models, including targeted metabolomics, assessment of mitophagy, and oxidative stress. Mitochondrial-nuclear exchange models are also available to enable experiments that evaluate the contribution of mtDNA variation to bioenergetics. Third, the Comparative Data Analytics Core will provide innovative analytic approaches to data sets linking comparative energetics to organismal health and longevity. With these research cores plus the administrative and research development core, we aim to: (i) facilitate hypothesis-driven research and leverage these technologies into new projects, interactions, and collaborations nationwide in basic aging research; (ii) foster meaningful novel interactions among investigators within UAB and across the region and country; and (iii) provide resources, education, training, and direction to junior investigators through the intellectual resources and research infrastructure, the Center will develop. In sum, these cores and the outstanding cohort of investigators assembled for this Center will provide unique expertise and novel collaborative opportunities for new and established investigators at UAB and beyond.

描述（由申请人提供）：位于伯明翰的亚拉巴马大学（UAB）建议建立一个内森休克卓越中心，专注于比较能量学和衰老的基础生物学。能量学被广泛定义为研究代谢能的获取、储存和利用的原因、机制和后果。比较能量学是在多个尺度和跨多个物种的代谢过程的研究，在这种情况下，因为它涉及到健康和衰老。近世纪的老龄化研究加强了能量学和老龄化之间的联系。在现代术语中，这种联系被具体化为线粒体功能失调，代谢信号和营养反应。该中心的双重目标将是（1）探索 比以前更深入和详细的细胞和有机体能量学之间的复杂关系，以及它们与健康和衰老的关系，（2）提供定量的，最先进的技术和新的方法，在评估和分析能量学的基础老龄化研究社区。为了实现这些目标，我们建议开发三个研究核心。首先，比较有机体能量学核心将提供专业知识和尖端的指导和方法，用于确定完整的整个动物能量平衡（摄入，同化，支出）和身体组成，包括白色和棕色脂肪组织的区域分布，在各种物种的活动物，包括苍蝇，鱼，老鼠 或其它哺乳动物的任何环境温度或活动状态下。其次，比较线粒体健康评估核心将为传统和新兴动物模型提供细胞器，细胞或组织水平的综合，定量能量学分析，包括靶向代谢组学，线粒体自噬评估和氧化应激。线粒体-核交换模型也可用于评估mtDNA变异对生物能量学的贡献的实验。第三，比较数据分析核心将提供创新的分析方法，将比较能量学与生物体健康和寿命联系起来。 有了这些研究核心加上行政和研究开发核心，我们的目标是：（i）促进假设驱动的研究，并利用这些技术到新的项目，互动，并在全国范围内的基础老龄化研究合作;（ii）促进有意义的新的UAB内部和整个地区和国家的研究人员之间的互动;以及（iii）通过智力资源和研究基础设施，为初级研究人员提供资源、教育、培训和指导。 总之，这些核心和为该中心聚集的优秀研究者队列将为UAB及其他地区的新老研究者提供独特的专业知识和新颖的合作机会。