Mentoring Translational Researchers in Louisiana

指导路易斯安那州的转化研究人员

• 批准号: 8883035
• 负责人: AUGUSTO C. OCHOA
• 金额: $ 109.5万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8883035
• 关键词: AIDS Malignancy Consortium; AIDS/HIV problem; Academic Medical Centers; Address; Affect; Apoptosis; Award; Back; Biological; Biomedical Research; Cancer Center; Centers of Research Excellence; Cessation of life; Chronic; Clinical; Clinical Trials; Core Facility; Critiques; Development; Disease; Ensure; Evaluation; Extramural Activities; Faculty; Funding; Funding Opportunities; Generations; Goals; Grant; Health; Health Sciences; Healthcare; Hospitals; Hurricane; Immune response; Immunity; Individual; Inflammation; Inflammatory; Institution; Investigation; Lead; Leadership; Louisiana; Malignant - descriptor; Malignant Neoplasms; Mentors; Mentorship; Minority; Molecular; Molecular Genetics; Normal tissue morphology; Obesity; Patients; Peer Review; Phase; Pilot Projects; Population; Preventive; Process; Recruitment Activity; Regulation; Research; Research Personnel; Research Project Grants; Research Support; Resources; Secure; Technology; Therapeutic; Time; Training; Translating; Translational Research; Underrepresented Minority; United States Department of Veterans Affairs; United States National Institutes of Health; Virus; Work; base; bench to bedside; biobank; career; catalyst; design; expectation; experience; health disparity; infrastructure development; innovation; minority health; novel; novel diagnostics; prevent; programs; promoter; public health relevance; research study; success; tool; tumor; tumor microenvironment; virus genetics

 DESCRIPTION (provided by applicant): The COBRE "Mentoring Translational Researcher in Louisiana" was the first program in Louisiana to focus and train a new generation of researchers on the intricacies of translating research "from the bench to the bedside and back." Started in the immediate post-Hurricane Katrina crisis, the results of work supported by this COBRE went above and beyond expectations. COBRE funded research helped establish teams of highly productive researchers that developed unique translational research programs addressing the health issues that affect the citizens of Louisiana, in particular the underserved minorities. Research has centered on the scientific goal of understanding the cellular, genetic and molecular mechanisms regulating chronic inflammation as the initiator and promoter of disease. COBRE researchers developed unique observations on viruses, immunity and cancer; obesity and disease; and the molecular regulation of inflammation in cancer. They also established cutting-edge scientific cores, and catalyzed the development of infrastructure such as the Tumor and HIV/AIDS Biorepositories, the only AIDS Malignancy Consortium Center in the region, and the only state wide clinical trials program. COBRE research helped multiply the number of extramural grants, including an NIH Directors Transformative Award. In addition, unique and novel observations resulted in the development of major NIH supported programs including a new Center for Minority Health and Health Disparities. This COBRE was also essential in recruiting established investigators that have expanded the depth and scope of our research. Phase III will provide investigators with an integrated "one-stop shop" research and support program that provides scientific planning and mentoring by senior researchers, access to cutting edge scientific cores, and a dedicated grants development team and administrative support to oversee the fiscal aspects of research. This approach will provide new opportunities for promising junior investigators (PJI) and senior researchers developing individual research projects or team-based investigation on the molecular determinants of inflammation and its impact on disease, with particular emphasis on minority populations. The scientific results and the grants obtained, and the integration of the scientific cores within the LSU Health Sciences Center will ensure the long-term stability and success of this research program. To achieve this we propose to: 1) Provide researchers with an integrated translational research support program; 2) Provide funding opportunities through a Pilot Projects Program to promising junior investigators (PJI) eager to develop independent research careers, or to teams of researchers developing highly innovative translational research; 3) Complete the integration of the Scientific Cores into the LSU Cancer Center at the LSU Health Sciences Center.

 描述（由申请人提供）：COBRE“指导路易斯安那州的翻译研究员”是路易斯安那州的第一个项目，旨在关注和培训新一代研究人员了解翻译研究的复杂性“从长凳到床边和背部。“从卡特里娜飓风危机后立即开始，COBRE支持的工作成果超出了预期。COBRE资助的研究帮助建立了高生产力的研究人员团队，开发了独特的转化研究计划，解决影响路易斯安那州公民的健康问题，特别是服务不足的少数民族。研究集中在理解慢性炎症作为疾病的引发者和促进者的细胞、遗传和分子机制的科学目标上。COBRE研究人员对病毒，免疫和癌症;肥胖和疾病;以及癌症炎症的分子调控进行了独特的观察。他们还建立了尖端的科学核心，并促进了基础设施的发展，如肿瘤和艾滋病毒/艾滋病生物储存库，该地区唯一的艾滋病研究联盟中心，以及唯一的全州临床试验计划。COBRE的研究帮助增加了校外赠款的数量，包括NIH主任变革奖。此外，独特和新颖的观察结果导致了NIH支持的主要项目的发展，包括一个新的少数民族健康和健康差异中心。这个COBRE在招募成熟的调查人员方面也是必不可少的，这些调查人员扩大了我们研究的深度和范围。第三阶段将为研究人员提供一个综合的“一站式”研究和支持计划，由高级研究人员提供科学规划和指导，获得尖端科学核心，以及专门的赠款开发团队和行政支持，以监督研究的财务方面。这种方法将为有前途的初级研究人员（PJI）和高级研究人员提供新的机会，他们将开发个人研究项目或基于团队的炎症分子决定因素及其对疾病的影响的研究，特别强调少数群体。科学成果和获得的赠款，以及路易斯安那州立大学健康科学中心内科学核心的整合将确保该研究计划的长期稳定和成功。为了实现这一目标，我们建议：1）为研究人员提供一个综合的翻译研究支持计划; 2）通过试点项目计划提供资金的机会，有前途的初级研究人员（PJI）渴望发展独立的研究事业，或研究人员团队发展高度创新的翻译研究; 3）完成科学核心到路易斯安那州立大学癌症中心在路易斯安那州立大学健康科学中心的整合。