Mentoring Translational Researchers in Louisiana

指导路易斯安那州的转化研究人员

• 批准号: 8883035
• 负责人: AUGUSTO C. OCHOA
• 金额: $ 109.5万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8883035
• 关键词: AIDS Malignancy Consortium; AIDS/HIV problem; Academic Medical Centers; Address; Affect; Apoptosis; Award; Back; Biological; Biomedical Research; Cancer Center; Centers of Research Excellence; Cessation of life; Chronic; Clinical; Clinical Trials; Core Facility; Critiques; Development; Disease; Ensure; Evaluation; Extramural Activities; Faculty; Funding; Funding Opportunities; Generations; Goals; Grant; Health; Health Sciences; Healthcare; Hospitals; Hurricane; Immune response; Immunity; Individual; Inflammation; Inflammatory; Institution; Investigation; Lead; Leadership; Louisiana; Malignant - descriptor; Malignant Neoplasms; Mentors; Mentorship; Minority; Molecular; Molecular Genetics; Normal tissue morphology; Obesity; Patients; Peer Review; Phase; Pilot Projects; Population; Preventive; Process; Recruitment Activity; Regulation; Research; Research Personnel; Research Project Grants; Research Support; Resources; Secure; Technology; Therapeutic; Time; Training; Translating; Translational Research; Underrepresented Minority; United States Department of Veterans Affairs; United States National Institutes of Health; Virus; Work; base; bench to bedside; biobank; career; catalyst; design; expectation; experience; health disparity; infrastructure development; innovation; minority health; novel; novel diagnostics; prevent; programs; promoter; public health relevance; research study; success; tool; tumor; tumor microenvironment; virus genetics

 DESCRIPTION (provided by applicant): The COBRE "Mentoring Translational Researcher in Louisiana" was the first program in Louisiana to focus and train a new generation of researchers on the intricacies of translating research "from the bench to the bedside and back." Started in the immediate post-Hurricane Katrina crisis, the results of work supported by this COBRE went above and beyond expectations. COBRE funded research helped establish teams of highly productive researchers that developed unique translational research programs addressing the health issues that affect the citizens of Louisiana, in particular the underserved minorities. Research has centered on the scientific goal of understanding the cellular, genetic and molecular mechanisms regulating chronic inflammation as the initiator and promoter of disease. COBRE researchers developed unique observations on viruses, immunity and cancer; obesity and disease; and the molecular regulation of inflammation in cancer. They also established cutting-edge scientific cores, and catalyzed the development of infrastructure such as the Tumor and HIV/AIDS Biorepositories, the only AIDS Malignancy Consortium Center in the region, and the only state wide clinical trials program. COBRE research helped multiply the number of extramural grants, including an NIH Directors Transformative Award. In addition, unique and novel observations resulted in the development of major NIH supported programs including a new Center for Minority Health and Health Disparities. This COBRE was also essential in recruiting established investigators that have expanded the depth and scope of our research. Phase III will provide investigators with an integrated "one-stop shop" research and support program that provides scientific planning and mentoring by senior researchers, access to cutting edge scientific cores, and a dedicated grants development team and administrative support to oversee the fiscal aspects of research. This approach will provide new opportunities for promising junior investigators (PJI) and senior researchers developing individual research projects or team-based investigation on the molecular determinants of inflammation and its impact on disease, with particular emphasis on minority populations. The scientific results and the grants obtained, and the integration of the scientific cores within the LSU Health Sciences Center will ensure the long-term stability and success of this research program. To achieve this we propose to: 1) Provide researchers with an integrated translational research support program; 2) Provide funding opportunities through a Pilot Projects Program to promising junior investigators (PJI) eager to develop independent research careers, or to teams of researchers developing highly innovative translational research; 3) Complete the integration of the Scientific Cores into the LSU Cancer Center at the LSU Health Sciences Center.

 描述（由适用提供）：路易斯安那州的“指导翻译研究人员”是路易斯安那州的第一个计划，重点介绍并培训新一代研究人员关于“从长凳到床边和背部”翻译研究的复杂性。始于直接发生的赫里里卡飓风危机，这家鞋匠支持的工作结果超出了预期。 COBRE资助的研究帮助建立了高产研究人员的团队，这些研究人员开发了独特的转化研究计划，以解决影响路易斯安那州公民的健康问题，尤其是服务不足的少数民族。研究集中在理解细胞，遗传和分子机制的科学目标上，调节慢性感染是疾病的发起者和启动子。毛病研究人员对病毒，免疫学和癌症进行了独特的观察。肥胖和疾病；以及癌症感染的分子调节。他们还建立了尖端的科学核心，并促进了基础设施的发展，例如肿瘤和艾滋病毒/艾滋病生物库，这是该地区唯一的艾滋病恶性财团中心，也是唯一的全州广泛的临床试验计划。 Cobre Research有助于多个校外赠款的数量，包括NIH导演的变革性奖励。此外，独特而新颖的观察结果导致了NIH主要支持计划的发展，包括新的少数族裔健康和健康差异中心。这种毛绒对于招募已扩大我们研究深度和范围的研究人员也至关重要。第三阶段将为调查人员提供一个综合的“一站式商店”研究与支持计划，该计划提供高级研究人员的科学计划和心理，获得最先进的科学核心，以及专门的赠款发展团队和行政支持，以监督研究的财务方面。这种方法将为有前途的初级调查人员（PJI）和开发个人研究项目的高级研究人员提供新的机会，或者基于团队的感染分子决定剂及其对疾病的影响，特别是重点是少数人群。科学结果和获得的赠款，以及在LSU健康科学中心内的科学核心的整合将确保该研究计划的长期稳定性和成功。为了实现这一目标，我们建议：1）为研究人员提供集成的翻译研究支持计划； 2）通过试点项目计划提供资金机会，以承诺渴望发展独立研究职业的初级调查人员（PJI），或者向开发高度创新的翻译研究的研究人员团队； 3）将科学核心整合到LSU健康科学中心的LSU癌症中心。