Cell Immunology and Metabolism Core (CIMC)
细胞免疫学与代谢核心(CIMC)
基本信息
- 批准号:10223346
- 负责人:
- 金额:$ 2.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-15 至 2022-07-14
- 项目状态:已结题
- 来源:
- 关键词:AntigensBiological AssayBiological MarkersBiological Response ModifiersBiopsyCancer CenterCell CycleCell DeathCell ProliferationCell SeparationCell SurvivalCell-Mediated CytolysisCellsCellular ImmunologyCenters of Research ExcellenceCommunitiesData AnalysesDetectionDevelopmentDiseaseEffectivenessEnergy MetabolismEquipmentEvaluationFatty AcidsFlow CytometryFoundationsFrequenciesFundingGene ExpressionGenus HippocampusGoalsHealth systemHuman ResourcesImmuneImmunoassayImmunologyIn VitroInflammationInfrastructureInstitutionInternetLaboratoriesLaboratory PersonnelLinkLouisianaMalignant NeoplasmsMediationMentorsMetabolicMetabolic MarkerMetabolismMitochondriaMitogensNitrogenOncologyOncoproteinsOxygenOxygen ConsumptionPathway interactionsPhasePhosphoproteinsPopulationPositioning AttributeProductionProtocols documentationPublicationsResearch PersonnelResearch Project GrantsResearch SupportResourcesRunningSerumServicesSignal TransductionSorting - Cell MovementSpeedSystemTechnologyTestingTimeTissuesTrainingTranslational ResearchUniversitiesViralVirusWorkanticancer researchanticancer treatmentbasecell growthcytokinecytotoxiceffector T cellepigenetic regulationexperimental studyglucose uptakeinnovationinstrumentinstrumentationmedical schoolsmeetingsneoplastic cellnew technologynovelnovel therapeuticsresponsesocial mediastemnesstumortumor immunologytumor metabolismvirus related cancer
项目摘要
ABSTRACT
The Cellular Immunology and Metabolism Core (CIMC) of the LSU Cancer Center provides cutting edge flow
cytometry, immunology and metabolism technologies LSUHSC investigators including COBRE PJI's, and to
other users in our region. The CIMC laboratory now provides comprehensive analytic flow cytometry, high-
speed cell sorting services, functional assays including antigen-specific and mitogen-induced cell proliferation,
cytokine production, cell death and survival, cell mediated cytotoxicity, and effector T cell frequency. The CIMC
also acquired and developed the infrastructure and expertise to study cellular metabolism, including oxygen
consumption and acidification rates, mitochondrial function; and the detection of immune mediators through
multiplex approaches. Therefore, state-of-the-art services of the CIMC are very well suited to support the
needs of PJIs of the new Phase I COBRE application ”Center for translational Viral Oncology” (CTVO). This
will be done by fully utilizing present services and resources, and by expending their expertise to identify new
biomarkers for virus-induced cancer, evaluation of cell growth and cell death responses associated with the
expression of viral oncoproteins and anticancer treatment. In addition, innovative approaches, which are
continuously implemented by the CIMC personnel will allow PJIs and their mentors to develop new
experimental strategies explaining virus-induced changes at the levels of tumor cell signaling, epigenetic
regulation and tumor cell energy metabolism, thereby increasing their chances for high impact publications and
federal and foundation-related funding. These advanced technologies have positioned the CIMC as the leading
laboratory in cancer and immunology in the region, which has resulted in an increased number of users,
including PJIs of the CTVO, and its integration as a core laboratory at the LSUHSC School of Medicine and the
LSU-Cancer Center.
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摘要
路易斯安那州立大学癌症中心的细胞免疫学和代谢核心(CIMC)提供尖端的流动
包括COBRE PJI在内的LSUHSC研究人员,以及
我们地区的其他用户。CIMC实验室现在提供全面的分析流式细胞术,高
加速细胞分选服务,功能性检测,包括抗原特异性和有丝分裂原诱导的细胞增殖,
细胞因子产生、细胞死亡和存活、细胞介导的细胞毒性和效应T细胞频率。中集
我还获得并发展了研究细胞代谢(包括氧气)的基础设施和专业知识
消耗和酸化率,线粒体功能;以及通过检测免疫介质
多元方法因此,中集集团最先进的服务非常适合支持
新一期COBRE申请“转化病毒肿瘤学中心”(CTVO)的PJIs需求。这
将通过充分利用现有的服务和资源,并通过扩大其专门知识,以确定新的
用于病毒诱导的癌症的生物标志物,与病毒诱导的癌症相关的细胞生长和细胞死亡应答的评价,
病毒癌蛋白的表达和抗癌治疗。此外,创新的方法,
由中集集团人员持续实施,将使PJIs及其导师能够开发新的
实验策略解释病毒诱导的肿瘤细胞信号水平的变化,表观遗传
调节和肿瘤细胞的能量代谢,从而增加他们的机会,高影响力的出版物,
联邦和基金会相关的资金。这些先进的技术使中集集团成为领先的
该区域的癌症和免疫学实验室,这导致用户人数增加,
包括CTVO的PJIs,以及它作为LSUHSC医学院和
路易斯安那州立大学癌症中心。
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项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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AUGUSTO C. OCHOA其他文献
AUGUSTO C. OCHOA的其他文献
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{{ truncateString('AUGUSTO C. OCHOA', 18)}}的其他基金
Project 2-Metabolic Modulation of Myeloid-Derived Suppressor Cells to Increase Efficacy of Neo adjuvant Chemotherapy and Immunotherapy
项目2-骨髓源性抑制细胞的代谢调节以提高新辅助化疗和免疫疗法的疗效
- 批准号:
10005254 - 财政年份:2018
- 资助金额:
$ 2.28万 - 项目类别:
Mentoring Translational Researchers in Louisiana
指导路易斯安那州的转化研究人员
- 批准号:
8883035 - 财政年份:2015
- 资助金额:
$ 2.28万 - 项目类别:
Gulf South Minority-based NCI Community Oncology Research Program
海湾南部少数民族 NCI 社区肿瘤学研究计划
- 批准号:
9328027 - 财政年份:2014
- 资助金额:
$ 2.28万 - 项目类别:
Gulf South Minority/Underserved Clinical Trials Network (Gulf South M/U CTN)
海湾南部少数民族/服务不足的临床试验网络(海湾南部 M/U CTN)
- 批准号:
10675065 - 财政年份:2014
- 资助金额:
$ 2.28万 - 项目类别:
Gulf South Minority/Underserved Clinical Trials Network (Gulf South M/U CTN)
海湾南部少数民族/服务不足的临床试验网络(海湾南部 M/U CTN)
- 批准号:
10197649 - 财政年份:2014
- 资助金额:
$ 2.28万 - 项目类别:
Gulf South Minority/Underserved Clinical Trials Network (Gulf South M/U CTN)
海湾南部少数民族/服务不足的临床试验网络(海湾南部 M/U CTN)
- 批准号:
10678186 - 财政年份:2014
- 资助金额:
$ 2.28万 - 项目类别:
Gulf South Minority-based NCI Community Oncology Research Program
海湾南部少数民族 NCI 社区肿瘤学研究计划
- 批准号:
8901096 - 财政年份:2014
- 资助金额:
$ 2.28万 - 项目类别:
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