Improving Antiretroviral Management for HIV

改善艾滋病毒抗逆转录病毒治疗

• 批准号: 8848023
• 负责人: RICHARD H HAUBRICH
• 金额: $ 19.31万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-15 至 2015-03-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8848023
• 关键词: Adherence; African American; Anti-Retroviral Agents; Antiretroviral resistance; Applications Grants; Behavior; Behavioral; California; Caregivers; Censuses; Chlamydia trachomatis; Clinical; Clinical Research; Communicable Diseases; Communities; Data; Development; Dose; Drug resistance; Ensure; Ethnic Origin; Event; Faculty; Failure; Family member; Funding; Gender; Goals; Grant; HIV; Incidence; Individual; Ingestion; Institutional Review Boards; Internet; Intervention; Investigation; Laboratories; Measures; Mentors; Methodology; Methods; Molecular; Neisseria gonorrhoeae; Outcome; Pathogenesis; Patients; Phylogenetic Analysis; Physicians; Prevalence; Principal Investigator; Process; Publications; Race; Research Project Grants; Resistance; Risk; Risk Factors; Risk Reduction; Sampling; Science; Scientist; Site; Surveys; Syphilis; System; Tenofovir; Time; Training Programs; Walkers; Woman; Work; Writing; career; cohort; data sharing; efavirenz; emtricitabine; graduate student; high risk behavior; high risk sexual behavior; improved; medication compliance; meetings; men; mucosal site; next generation; novel; protocol development; sensor; sexually active; transmission process; trend

DESCRIPTION (provided by applicant): The goal of this K24 renewal application is to allow the applicant to continue to mentor trainees pursuing a career in clinical HIV investigation. This application would provide continued opportunities to utilize ongoing and planned clinical studies to mentor Infectious Disease fellows, junior faculty and graduate students in HIV related clinical research projects through the UCSD AVRC, the California Collaborative Treatment Group (CCTG) and the CFAR Network of Integrated Clinical Systems (CNICS) and to continue to expand the applicant's participation in the UCSD training programs for clinical research. The studies outlined in the aims provide opportunities for in-depth mentoring as well as investigation of timely and important scientific questions in HIV management and pathogenesis. For each of the aims and sub-aims, a mentee is the primary leader of the study: trainees have worked with the applicant to develop the studies from the inception and will participate in every aspect of protocol development, study execution, statistical analyses, results interpretation, presentation and publication of the results. All of the main studies are funded (mentees participated in the grant writing process) and for laboratory sub-aims, trainees have participated in recently submitted grant applications. The goal of mentoring will be achieved through the conduct of 2 scientific aims which incorporate several clinical studies. SPECIFIC AIM 1: To analyze CNICS cohort data to evaluate trends in antiretroviral (ARV) exposure and resultant virologic and resistance outcomes including disparities in outcome among women and African Americans. Clinical Studies: CNICS 002, CNICS 019 plus new CNICS concept proposal in development. SPECIFIC AIM 2: To investigate technologic and behavioral methodologies which improve adherence to ARV and reduce high-risk behavior in order to potentially reduce transmission from HIV- infected subjects. Clinical studies: CCTG 592 and new CCTG studies in development. The goal of this project is to allow the Principal Investigator to continue to mentor trainees pursuing a career in clinical HIV investigation. This application would provide continued opportunities to utilize ongoing and planned clinical studies to mentor Infectious Disease fellows, junior faculty and graduate students in HIV related clinical research projects through the UCSD AVRC, the California Collaborative Treatment Group (CCTG) and the CFAR Network of Integrated Clinical Systems (CNICS). Ultimately, the project would help to ensure that the next generation of scientists is available to meet the challenges of improving science and treatment of HIV infected patients.

描述（由申请人提供）：本 K24 续签申请的目的是让申请人能够继续指导从事临床 HIV 调查职业的学员。该申请将提供持续的机会，利用正在进行的和计划中的临床研究，通过 UCSD AVRC、加州合作治疗组 (CCTG) 和 CFAR 综合临床系统网络 (CNICS) 指导传染病研究员、初级教师和研究生参与 HIV 相关临床研究项目，并继续扩大申请人对 UCSD 临床研究培训计划的参与。目标中概述的研究为深入指导以及研究艾滋病毒管理和发病机制中及时且重要的科学问题提供了机会。对于每个目标和子目标，受训者是研究的主要领导者：受训者从一开始就与申请人一起开发研究，并将参与方案制定、研究执行、统计分析、结果解释、结果呈现和结果发布的各个方面。所有主要研究均获得资助（受训者参与了资助撰写过程），对于实验室子目标，受训者参与了最近提交的资助申请。 指导目标将通过实施两项科学目标来实现，其中包括多项临床研究。具体目标 1：分析 CNICS 队列数据，以评估抗逆转录病毒 (ARV) 暴露趋势以及由此产生的病毒学和耐药结果，包括女性和非裔美国人之间的结果差异。临床研究：CNICS 002、CNICS 019 以及正在开发的新 CNICS 概念提案。具体目标 2：研究提高 ARV 依从性并减少高危行为的技术和行为方法，以潜在地减少 HIV 感染者的传播。临床研究：CCTG 592 和新的 CCTG 研究正在开发中。 该项目的目标是让首席研究员继续指导从事临床艾滋病毒调查职业的学员。该应用程序将提供持续的机会，利用正在进行的和计划中的临床研究，通过 UCSD AVRC、加州合作治疗组 (CCTG) 和 CFAR 综合临床系统网络 (CNICS) 指导传染病研究员、初级教师和研究生参与 HIV 相关临床研究项目。最终，该项目将有助于确保下一代科学家能够应对改进科学和治疗艾滋病毒感染患者的挑战。

项目成果

Comparisons of reported sexual behaviors from a retrospective survey versus a prospective diary in the Botswana Defence Force.

• DOI: 10.1521/aeap.2013.25.6.495
• 发表时间: 2013-12
• 期刊: AIDS education and prevention : official publication of the International Society for AIDS Education
• 作者: Tran BR;Thomas AG;Vaida F;Ditsela M;Phetogo R;Kelapile D;Chambers C;Haubrich R;Shaffer R
• 通讯作者: Shaffer R

Will risk compensation accompany pre-exposure prophylaxis for HIV?

• DOI: 10.1001/virtualmentor.2014.16.11.stas1-1411
• 发表时间: 2014-11-01
• 期刊: The virtual mentor : VM
• 作者: Blumenthal, Jill;Haubrich, Richard H
• 通讯作者: Haubrich, Richard H

A computer-based system to aid in the interpretation of plasma concentrations of antiretrovirals for therapeutic drug monitoring.

一种基于计算机的系统，有助于解释抗逆转录病毒药物的血浆浓度，以进行治疗药物监测。

• 发表时间: 2007
• 期刊: Antiviral therapy
• 影响因子: 1.2
• 作者: Goicoechea,Miguel;Vidal,Andrea;Capparelli,Edmund;Rigby,Andrew;Kemper,Carol;Diamond,Catherine;Witt,MalloryD;Haubrich,Richard;CaliforniaCollaborativeTreatmentGroup
• 通讯作者: CaliforniaCollaborativeTreatmentGroup