ACTG A5079 PHYSIOLOGIC TESTOSTERONE SUPPLEMENTATION IN HIV

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。对于血清睾酮水平轻度至中度下降的HIV阳性腹型肥胖男性，测试这样一种假设，即从基线到24周，服用睾丸素的男性内脏脂肪横截面积的变化将大于服用安慰剂的情况。评估这种治疗的安全性和耐受性。评价睾酮替代治疗对脂代谢的影响。用DEXA和CT评估局部脂肪。评估睾酮替代疗法对瘦体重的影响。评估对腰臀比和腹围的影响，评估对生活质量和身体形象的影响，评估睾酮替代治疗效果的48周持久性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Test the hypothesis that the change in visceral fat cross-sectional area from baseline to 24 weeks will be greater with testosterone replacement than with placebo in HIV-positive men with abdominal obesity who have mildly to moderately reduced serum testosterone levels. Evaluate the safety and tolerability of this treatment. Evaluate the effect of testosterone replacement on lipid metabolism. Assess regional fat by DEXA and CT. Evaluate the effect of testosterone replacement on lean body mass. Evaluate the effect on waist-to-hip ratio and abdominal circumfrance, evaluate effect on quality of life and body image, and evaluate the 48 week durability of the effect of testosterone replacement.