ACTG A5079 PHYSIOLOGIC TESTOSTERONE SUPPLEMENTATION IN HIV

ACTG A5079 HIV 患者的生理睾酮补充

• 批准号: 7374162
• 负责人: RICHARD H HAUBRICH
• 金额: $ 0.39万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374162
• 关键词: fats; testosterone

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Test the hypothesis that the change in visceral fat cross-sectional area from baseline to 24 weeks will be greater with testosterone replacement than with placebo in HIV-positive men with abdominal obesity who have mildly to moderately reduced serum testosterone levels. Evaluate the safety and tolerability of this treatment. Evaluate the effect of testosterone replacement on lipid metabolism. Assess regional fat by DEXA and CT. Evaluate the effect of testosterone replacement on lean body mass. Evaluate the effect on waist-to-hip ratio and abdominal circumfrance, evaluate effect on quality of life and body image, and evaluate the 48 week durability of the effect of testosterone replacement.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。在血清睾酮水平轻度至中度降低的hiv阳性腹部肥胖男性中，睾酮替代比安慰剂从基线到24周内脏脂肪横截面积的变化更大，这一假设得到验证。评估这种治疗的安全性和耐受性。评价睾酮替代对脂质代谢的影响。通过DEXA和CT评估区域脂肪。评估睾酮替代对瘦体重的影响。评估对腰臀比和腹围的影响，评估对生活质量和身体形象的影响，评估睾酮替代效果的48周持久性。