Improving Antiretroviral Management for HIV

改善艾滋病毒抗逆转录病毒治疗

• 批准号: 7578888
• 负责人: RICHARD H HAUBRICH
• 金额: $ 16.94万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-15 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7578888
• 关键词: AIDS clinical trial group; Anti-Retroviral Agents; California; Clinic; Clinical; Clinical Management; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Communicable Diseases; Development; Drug Kinetics; Drug Monitoring; Evaluation; Faculty; Failure; Fostering; Funding; Genetic; Genetic Crossing Over; Genetic Polymorphism; Genetic Variation; Goals; HIV; Lopinavir; Master of Public Health; Mentors; Nucleosides; Outcome; Pathogenesis; Pathway interactions; Patients; Principal Investigator; Randomized Controlled Trials; Research; Research Personnel; Research Project Grants; Role; Students; Therapeutic; Training; Viral; antiretroviral therapy; base; design; graduate student; improved; insight; patient oriented research; response; treatment response

The goal of this project is to conduct high quality patient oriented research with HIV infected patients which focuses on answering clinical and pathogenesis based questions concerning antiretroviral therapy and evaluates new and emerging strategies to improve the clinical management of antiretroviral therapy. The central hypothesis of the project is that carefully planned and analyzed studies can not only answer questions about specific treatment combinations, but can also provide insight into the pathogenesis of treatment responses and define strategies to manage patients in the clinic. Mentoring young investigators (M.P.H. students, Infectious Disease fellows, and junior faculty) will be a central goal of this project. These goals will be accomplished by conceiving, designing, initiating, carrying out, and analyzing randomized controlled trials in collaboration with local (UCSD AVRC), statewide (California Collaborative Treatment Group [CCTG]), and national (AIDS Clinical Trials Group [ACTG]) clinical trials organizations. As the overall Principal Investigator of the CCTG, I will be able to continue the tradition of fostering the development of junior investigators through active participation in CCTG studies. The primary research theme is to understand the antiretroviral exposure-response relationship and its implications for the pathogenesis and management of HIV. The specific aims are: 1) To examine the mechanistic pathways leading to therapeutic failure of TDF + ABC by evaluating nucleoside plasma and intracellular exposure-response relationships. The study will use a unique clinical trial design (cross-over, pharmacokinetic evaluation of short-term viral dynamics) to evaluate the interaction between TDF and ABC. 2) To define the role of antiretroviral exposure-response relationships in HIV therapeutics. Aim 2A: To evaluate the value of therapeutic drug monitoring (TDM) to improve the management and outcome of antiretroviral therapy. Aim 2B: To define the impact of genetic differences (defined by allelic variants of single nucleoside polymorphisms) on exposure and response to lopinavir, the antiretroviral agent.

该项目的目标是对艾滋病毒感染患者进行高质量的以患者为导向的研究