Clinical Investigation

临床研究

• 批准号: 7278950
• 负责人: RICHARD H HAUBRICH
• 金额: $ 23.3万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7278950
• 关键词: AIDS prevention; Adult; Antiviral Agents; Awareness; Behavioral; Biometry; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Collaborations; Communication; Communities; Community Outreach; Computerized Medical Record; Consultations; Data; Data Collection; Data Element; Databases; Development; Disease; Education; Education and Outreach; Educational process of instructing; Environment; Evaluation; Faculty; Fostering; Funding; Future; HIV; Health Personnel; Human Resources; Individual; Industry; Infection; Injecting drug user; Institution; Interdisciplinary Study; Laboratories; Measures; Medical Education; Mentors; Minority; Outcome; Outcomes Research; Pathogenesis; Patient Education; Patient Recruitments; Patients; Pharmacists; Physicians; Population; Process; Publications; Range; Research; Research Design; Research Infrastructure; Research Methodology; Research Personnel; Resistance; Resources; Scientist; Services; Site; Students; System; Training; Training Support; Training and Education; Translational Research; Underrepresented Minority; Woman; Work; abstracting; base; cohort; design; experience; outreach; outreach program; programs; quality assurance; sample collection

The UCSD CFAR Clinical Investigation Core promotes translational, epidemiologic, and outcomes research in HIV disease by providing access to an established and successful infrastructure. The objectives of the Core are as follows: (1) provide the services, expertise, and environment necessary for clinical investigation and translational research; (2) provide access to a longitudinal database for epidemiologic, behavioral, and outcomes research; (3) foster communication and collaboration between basic and clinical investigators in academics and industry; (4) support training of junior HIV investigators and education of medical personnel; and (5) provide education and awareness of HIV-related research opportunities and CFAR research findings to all HIV-infected individuals, including women and minorities. To meet these objectives, the resources of a large, well-established clinical trials unit are made accessible to a broad range of clinical investigators for pilot and funded projects. Physicians, basic scientists, pharmacists, fellows, junior faculty, and students use Core services. The Core has also processed requests from academic institutions outside UCSD. The Core provides a full range of services, including patient outreach and recruitment; specimen collection; data collection, entry, and analysis; trial design consultation; training of clinical research personnel; and access to a longitudinal, 5,000-patient database containing cumulative clinical, behavioral, and laboratory indicators for epidemiologic- and outcomes-related research. In addition, the Core Directors and affiliated experienced investigators mentor junior investigators and participate in CFAR didactic courses in clinical research methods and biostatistics. The opportunities for outcomes and translational work have been expanded with the CNICS (CFAR Network of Integrated Clinical Systems) project, a collaboration of seven CFAR sites with electronic medical records databases. Core personnel have facilitated the addition of resistance data to the CNICS cohort. In addition, the Core supports an extensive community outreach and education program, which includes concerted efforts to reach women, minorities, and injection drug users. CFAR support of the Clinical Investigation Core has enabled the development of new funded programs, scientific collaborations, and numerous abstracts and publications. Future plans include (1) expanding outcome, resistance and translational research through the CNICS collaboration; (2) expanding the Core's current database to include patient-based measures and enhanced quality assurance of data elements; and (3) fostering multidisciplinary research in the many complications and co-infections that accompany

UCSD CFAR临床研究核心促进翻译、流行病学和结果研究 通过提供进入已建立和成功的基础设施的途径，在艾滋病毒疾病方面取得进展。该计划的目标 核心是：(1)提供临床所需的服务、专业知识和环境 调查和转化研究；(2)提供对流行病学纵向数据库的访问， 行为和结果研究；(3)促进基础和临床之间的沟通和合作 学术界和工业界的调查人员；(4)支持初级艾滋病毒调查人员的培训和教育 医务人员；及(5)提供与艾滋病毒有关的研究机会的教育和认识，以及 CFAR的研究结果适用于所有艾滋病毒感染者，包括妇女和少数族裔。为了满足这些要求 目标，一个大型的、完善的临床试验单位的资源被广泛地提供给 试点项目和资助项目的临床研究人员范围。 医生、基础科学家、药剂师、研究员、初级教员和学生使用核心服务。《核心》 还处理了加州大学圣地亚哥分校以外的学术机构的请求。酷睿提供了全方位的 服务，包括病人外展和招募；标本收集；数据收集、录入和 分析；试验设计咨询；临床研究人员的培训；以及获得纵向、 5,000名患者数据库，包含以下各项的累积临床、行为和实验室指标 流行病学和与结果相关的研究。此外，核心董事和联属公司经验丰富 研究人员指导初级研究人员，并参加临床研究中的CFAR教学课程 方法和生物统计学。 通过CNICs(CFAR)扩大了成果和翻译工作的机会 综合临床系统网络)项目，这是一个由七个CFAR站点与电子 病历数据库。核心人员协助将耐药性数据添加到CNIC 一群人。此外，该中心还支持广泛的社区外联和教育方案，该方案 包括共同努力接触妇女、少数民族和注射吸毒者。 CFAR对临床研究核心的支持使新资助项目的发展成为可能， 科学合作，以及大量摘要和出版物。未来的计划包括(1)扩大 通过CNICs合作的成果、阻力和翻译研究；(2)扩大核心的 目前的数据库包括以病人为基础的措施和加强数据要素的质量保证； 以及(3)促进对伴随而来的许多并发症和合并感染的多学科研究