Training of Surgeons for Studies of the Tumor Microenvironment

外科医生肿瘤微环境研究培训

• 批准号: 8999649
• 负责人: STEVEN K. LIBUTTI
• 金额: $ 13.22万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-25 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8999649
• 关键词: Surgeon; Training; tumor microenvironment

 DESCRIPTION (provided by applicant): This is a new application for funds to support The Ruth L. Kirschstein NRSA Institutional Research Training Grant (T32) titled "Training of Surgeons for Studies of the Tumor Microenvironment". The program is designed for surgical residents in the department of surgery to spend two years dedicated to training in the conduct of basic and translational research. The goal of our program is to provide a comprehensive curriculum for training surgical residents in the conduct of basic laboratory research focused on the study of the tumor microenvironment. Tumors are complex pseudo organs made up of a variety of cell types in addition to the tumor cells themselves. The recognition that these cell types interact with one another to create a novel tumor microenvironment has lead to important advances in both the understanding of tumor pathophysiology and in the identification of novel targets for cancer therapy. Advances in the understanding of the mechanisms controlling invasion and metastasis as well as the role of the immune system in tumor growth inhibition are examples of the coordination between host cells and neoplastic cells. By bringing together a team of mentors with a strong track record of research accomplishments as well as sustained experience in training post-graduate fellows, we plan to address an unmet need in the preparation of surgeons for a career in cancer research. Our application includes outstanding faculty mentors and co-mentors representing 6 clinical departments and 4 basic science departments. The 15 faculty members include 9 senior mentors, 3 co-mentors and 3 educators. Our goal is to improve the training of future surgeon scientists by providing them with the tools necessary to succeed in a scientific career. The training program will consist of two years of laboratory research, formal coursework and participation in relevant journal clubs and seminars. The training will also include participation in the department of surgery's annual research day and attendance at departmental and professional conferences and relevant workshops. Successful trainees will have submitted at least two abstracts to national meetings and at least one original manuscript for peer review by the completion of the training program. The curriculum is designed to prepare the trainee to pursue a career as a surgeon scientist. The program is structured with a formal evaluation process in place to evaluate trainee, mentor and overall program performance.

 描述（由应用程序提供）：这是支持Ruth L. Kirschstein NRSA机构研究培训补助金（T32）的新申请，标题为“肿瘤微环境研究的外科医生培训”。该计划是为手术系的外科居民设计的，花了两年时间致力于进行基础和翻译研究的培训。我们计划的目的是为培训外科居民提供一项全面的课程，以进行基础实验室研究，重点是研究肿瘤微环境。除了肿瘤细胞本身，肿瘤是由多种细胞类型组成的复杂伪器官。这些细胞类型彼此相互作用以创造新的肿瘤微环境的认识导致对肿瘤病理生理学的理解和鉴定新的癌症治疗靶标的了解。理解控制侵袭和转移机制的进步以及免疫系统在肿瘤生长抑制中的作用是宿主细胞与肿瘤细胞之间协调的例子。通过将一群导师团队汇集在一起​​，具有良好的研究成就以及持续的培训研究生研究员的经验，我们计划满足为外科医生准备癌症研究事业的未满足需求。我们的申请包括代表6个临床部门和4个基础科学部门的杰出教师和联合主管。 15名教职员工包括9名高级导师，3名合伙人和3名教育工作者。我们的目标是通过为在科学职业中取得成功所需的工具来改善对未来外科医生的培训。该培训计划将包括两年的实验室研究，正式课程以及参与相关期刊俱乐部和半人物。该培训还将包括参加外科部的年度研究日，以及参加部门和专业会议以及相关研讨会的出席。成功的受训者将在完成培训计划完成后至少向国家会议提交至少两个摘要，并至少有一个原始手稿进行同行评审。该课程旨在为受训者做好准备，以从事外科医生科学家的职业。该计划的结构是正式的评估过程，以评估学员，心理和整体计划表现。