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Multifunctional Nanoassemblies for Ligand-directed Imaging and Therapy of Endocri

用于内分泌配体定向成像和治疗的多功能纳米组件

基本信息

批准号：
8735865
负责人：
STEVEN K. LIBUTTI
金额：
$ 33.02万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-01 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8735865
关键词：
Address Adenocarcinoma Adhesions Archives Area Bacteriophages Blood Vessels Cancer Biology Cancer Center Collaborations Computer Simulation Detection Development Disease Drug Carriers Early Diagnosis Endocrine Engineering Generations Gold Heating Homing Human Image Immunohistochemistry Infrared Rays Islet Cell Tumor Ligands Liposomes Malignant Neoplasms Malignant neoplasm of ovary Methods Modality Molecular Nanotechnology Output Ovarian Pancreas Peptide Library Phage Display Pharmacologic Substance Positron-Emission Tomography Property Raman Spectrum Analysis Relative (related person)Sampling Science Services Shapes Signal Transduction Silicon Specificity Streptozocin Surface Surface Properties System Texas Therapeutic Therapeutic Agents Therapeutic Effect Thermal Ablation Therapy Tissues Tracer Transgenic Mice Translating Vascular Endothelium X-Ray Computed Tomography angiogenesis base biomathematics chemical property chemotherapy clinical application combinatorial density design human disease imaging probe in vivo mathematical model molecular imaging mouse model nano nanoassembly nanoengineering nanomedicine nanoparticle novel oncology ovarian neoplasm pancreatic neoplasm particle physical property receptor receptor expression response scaffold screening selective expression simulation targeted delivery tool tool development tumor vascular bed

项目摘要

PROJECT TITLE: Multifunctional Nanoassemblies for Ligand-Directed Imaging and Therapy of Endocrine Pancreatic Tumors PROJECT SUMMARY: The development of tools for the targeted delivery of Imaging-probes and therapeufic agents has become the focus of intense efforts in the context of many human diseases. The in vivo screening method in which phage can be selected from engineered combinatorial peptide libraries for their ability to target specific vascular beds has uncovered a vascular address system that allows specific angiogenesis-related targeting to blood vessels in cancer. This phage display-based targeting Is expanded by the direct-assembly of gold and nanoporous silicon nanoparticles onto phage for nanomedical applications. Through exploiting the nanodimensions of the phage particle as a molecular network we generated biologically active nanoassemblies (NAs) with concomitant unique and tunable chemical and physical properties. These properties include near-infrared (NIR) radiation conversion to heat, enhancement of fluorescent signals, NIR surface enhanced Raman scattering (SERS) and the ability to conjugate and incorporate therapies or imaging-tracers. This tuning capability combined with the programmable tissue targefing affords the Integrafion of multiple funcfionalities into a single NA and serves as a complementary and non-mutually exclusive tool among different applicafions, including chemotherapy targeting and molecular imaging. Project 4 aims to develop the ligand-directed Si particles- phage- Au particles NAs as novel systems for targeted imaging and therapy in endocrine pancreatic tumors. These efforts will be translated into wide-ranging clinical applications.

项目名称：用于内分泌胰腺肿瘤配体导向成像和治疗的多功能纳米组装体项目概要：用于成像探针和治疗剂的靶向递送的工具的开发已经成为许多人类疾病背景下的密集努力的焦点。体内筛选方法，其中噬菌体可以从工程化的组合肽文库中选择其靶向特定血管床的能力，已经揭示了血管寻址系统，其允许特异性血管生成相关靶向癌症中的血管。这种基于噬菌体展示的靶向通过将金和纳米多孔硅纳米颗粒直接组装到噬菌体上以用于纳米医学应用而扩展。通过利用噬菌体颗粒的纳米尺寸作为分子网络，我们产生了具有生物活性的纳米组装体（NAs），其具有独特的和可调的化学和物理性质。这些性质包括近红外（NIR）辐射转化为热、荧光信号增强、NIR表面增强的拉曼散射（Sers）以及结合和并入治疗或成像示踪剂的能力。这种调谐能力与可编程组织靶向相结合，提供了将多个功能集成到单个NA中，并在不同的应用（包括化疗靶向和分子成像）中用作互补和非相互排斥的工具。项目4旨在开发配体导向的Si颗粒-噬菌体- Au颗粒NAs作为胰腺内分泌肿瘤的靶向成像和治疗的新系统。这些努力将转化为广泛的临床应用。