Multifunctional Nanoassemblies for Ligand-directed Imaging and Therapy of Endocri

用于内分泌配体定向成像和治疗的多功能纳米组件

• 批准号: 8735865
• 负责人: STEVEN K. LIBUTTI
• 金额: $ 33.02万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8735865
• 关键词: Address; Adenocarcinoma; Adhesions; Archives; Area; Bacteriophages; Blood Vessels; Cancer Biology; Cancer Center; Collaborations; Computer Simulation; Detection; Development; Disease; Drug Carriers; Early Diagnosis; Endocrine; Engineering; Generations; Gold; Heating; Homing; Human; Image; Immunohistochemistry; Infrared Rays; Islet Cell Tumor; Ligands; Liposomes; Malignant Neoplasms; Malignant neoplasm of ovary; Methods; Modality; Molecular; Nanotechnology; Output; Ovarian; Pancreas; Peptide Library; Phage Display; Pharmacologic Substance; Positron-Emission Tomography; Property; Raman Spectrum Analysis; Relative (related person); Sampling; Science; Services; Shapes; Signal Transduction; Silicon; Specificity; Streptozocin; Surface; Surface Properties; System; Texas; Therapeutic; Therapeutic Agents; Therapeutic Effect; Thermal Ablation Therapy; Tissues; Tracer; Transgenic Mice; Translating; Vascular Endothelium; X-Ray Computed Tomography; angiogenesis; base; biomathematics; chemical property; chemotherapy; clinical application; combinatorial; density; design; human disease; imaging probe; in vivo; mathematical model; molecular imaging; mouse model; nano; nanoassembly; nanoengineering; nanomedicine; nanoparticle; novel; oncology; ovarian neoplasm; pancreatic neoplasm; particle; physical property; receptor; receptor expression; response; scaffold; screening; selective expression; simulation; targeted delivery; tool; tool development; tumor; vascular bed

PROJECT TITLE: Multifunctional Nanoassemblies for Ligand-Directed Imaging and Therapy of Endocrine Pancreatic Tumors PROJECT SUMMARY: The development of tools for the targeted delivery of Imaging-probes and therapeufic agents has become the focus of intense efforts in the context of many human diseases. The in vivo screening method in which phage can be selected from engineered combinatorial peptide libraries for their ability to target specific vascular beds has uncovered a vascular address system that allows specific angiogenesis-related targeting to blood vessels in cancer. This phage display-based targeting Is expanded by the direct-assembly of gold and nanoporous silicon nanoparticles onto phage for nanomedical applications. Through exploiting the nanodimensions of the phage particle as a molecular network we generated biologically active nanoassemblies (NAs) with concomitant unique and tunable chemical and physical properties. These properties include near-infrared (NIR) radiation conversion to heat, enhancement of fluorescent signals, NIR surface enhanced Raman scattering (SERS) and the ability to conjugate and incorporate therapies or imaging-tracers. This tuning capability combined with the programmable tissue targefing affords the Integrafion of multiple funcfionalities into a single NA and serves as a complementary and non-mutually exclusive tool among different applicafions, including chemotherapy targeting and molecular imaging. Project 4 aims to develop the ligand-directed Si particles- phage- Au particles NAs as novel systems for targeted imaging and therapy in endocrine pancreatic tumors. These efforts will be translated into wide-ranging clinical applications.

项目标题：用于胰腺内分泌肿瘤的配体导向成像和治疗的多功能纳米组件 项目概述：在许多人类疾病的背景下，开发定向递送成像探头和治疗剂的工具已成为紧张努力的重点。体内筛选方法可以从工程组合肽库中选择噬菌体，因为它们具有靶向特定血管床的能力，该方法揭示了一种血管地址系统，该系统允许在癌症中针对血管生成相关的特定靶向。这种基于噬菌体展示的靶向是通过将金和纳米多孔硅纳米颗粒直接组装到噬菌体上用于纳米医学应用而扩展的。通过利用噬菌体颗粒的纳米尺寸作为分子网络，我们产生了具有生物活性的纳米组件(NAS)，具有伴随的独特的和可调节的化学和物理性质。这些特性包括近红外(NIR)辐射到热的转换、荧光信号的增强、近红外表面增强拉曼散射(SERS)以及结合和整合疗法或成像示踪剂的能力。这种调谐能力与可编程的组织靶标相结合，将多种功能集成到单个NA中，并在不同的应用之间充当互补和非互斥的工具，包括化疗靶向和分子成像。项目4旨在开发配体导向的硅颗粒-噬菌体-金颗粒Nas作为胰腺内分泌肿瘤靶向成像和治疗的新系统。这些努力将转化为广泛的临床应用。