Multifunctional Nanoassemblies for Ligand-directed Imaging and Therapy of Endocri

用于内分泌配体定向成像和治疗的多功能纳米组件

基本信息

批准号：
8735865
负责人：
STEVEN K. LIBUTTI
金额：
$ 33.02万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-01 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8735865
关键词：
Address Adenocarcinoma Adhesions Archives Area Bacteriophages Blood Vessels Cancer Biology Cancer Center Collaborations Computer Simulation Detection Development Disease Drug Carriers Early Diagnosis Endocrine Engineering Generations Gold Heating Homing Human Image Immunohistochemistry Infrared Rays Islet Cell Tumor Ligands Liposomes Malignant Neoplasms Malignant neoplasm of ovary Methods Modality Molecular Nanotechnology Output Ovarian Pancreas Peptide Library Phage Display Pharmacologic Substance Positron-Emission Tomography Property Raman Spectrum Analysis Relative (related person)Sampling Science Services Shapes Signal Transduction Silicon Specificity Streptozocin Surface Surface Properties System Texas Therapeutic Therapeutic Agents Therapeutic Effect Thermal Ablation Therapy Tissues Tracer Transgenic Mice Translating Vascular Endothelium X-Ray Computed Tomography angiogenesis base biomathematics chemical property chemotherapy clinical application combinatorial density design human disease imaging probe in vivo mathematical model molecular imaging mouse model nano nanoassembly nanoengineering nanomedicine nanoparticle novel oncology ovarian neoplasm pancreatic neoplasm particle physical property receptor receptor expression response scaffold screening selective expression simulation targeted delivery tool tool development tumor vascular bed

项目摘要

PROJECT TITLE: Multifunctional Nanoassemblies for Ligand-Directed Imaging and Therapy of Endocrine Pancreatic Tumors PROJECT SUMMARY: The development of tools for the targeted delivery of Imaging-probes and therapeufic agents has become the focus of intense efforts in the context of many human diseases. The in vivo screening method in which phage can be selected from engineered combinatorial peptide libraries for their ability to target specific vascular beds has uncovered a vascular address system that allows specific angiogenesis-related targeting to blood vessels in cancer. This phage display-based targeting Is expanded by the direct-assembly of gold and nanoporous silicon nanoparticles onto phage for nanomedical applications. Through exploiting the nanodimensions of the phage particle as a molecular network we generated biologically active nanoassemblies (NAs) with concomitant unique and tunable chemical and physical properties. These properties include near-infrared (NIR) radiation conversion to heat, enhancement of fluorescent signals, NIR surface enhanced Raman scattering (SERS) and the ability to conjugate and incorporate therapies or imaging-tracers. This tuning capability combined with the programmable tissue targefing affords the Integrafion of multiple funcfionalities into a single NA and serves as a complementary and non-mutually exclusive tool among different applicafions, including chemotherapy targeting and molecular imaging. Project 4 aims to develop the ligand-directed Si particles- phage- Au particles NAs as novel systems for targeted imaging and therapy in endocrine pancreatic tumors. These efforts will be translated into wide-ranging clinical applications.

项目名称：用于配体指导成像和内分泌胰腺肿瘤疗法的多功能纳米仪表项目摘要：开发针对成像探针和治疗剂的目标交付工具的开发已成为许多人类疾病的强烈努力的重点。可以从工程组合肽库中选择噬菌体以靶向特定血管床的能力的体内筛查方法，它发现了一个血管地址系统，该系统允许特定的血管生成相关的靶向癌症中的血管。基于噬菌体显示的靶向是通过黄金和纳米多孔硅纳米颗粒的直接组装扩展到纳米医学应用的噬菌体上的。通过利用噬菌体颗粒的纳米二维为分子网络，我们生成具有独特且可调化的化学和物理特性的生物活性纳米夹（NAS）。这些特性包括近红外（NIR）辐射转换为热量，增强荧光信号，NIR表面增强的拉曼散射（SERS）以及结合并结合疗法或成像跟踪器的能力。这种调整能力与可编程组织的结合可以使多个函数的整合到单个NA中，并在不同的应用程序中充当互补和非纯粹的独占工具，包括靶向化学疗法和分子成像。项目4旨在开发配体指导的Si颗粒 - 噬菌体颗粒NAS作为内分泌胰腺肿瘤中靶向成像和治疗的新型系统。这些努力将转化为广泛的临床应用。