Comprehensive Assessment of Retinal Vasculature (CARV)
视网膜血管系统综合评估(CARV)
基本信息
- 批准号:8905943
- 负责人:
- 金额:$ 68.93万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-03-01 至 2017-08-31
- 项目状态:已结题
- 来源:
- 关键词:AdoptionAgeAge-YearsAlgorithmsArteriesCardiovascular DiseasesCardiovascular systemClassificationClinicClinical TrialsCopperDataDatabasesDetectionDevicesDiabetic RetinopathyDiagnosticDiagnostic ProcedureDiseaseEmbolismEnvironmentEventHeart failureHemorrhageHypertensive RetinopathyImageIncidenceIndividualInstitutesIntentionLesionLocationManualsMarketingMeasurementMedicalMethodsMicroaneurysmMonitorMyocardial InfarctionOptometristPatientsPerformancePersonsPharmacy facilityPhasePopulationPrevalencePrimary Health CareProcessProspective StudiesReaderReadingReal-Time SystemsResearchResearch PersonnelRetinaRetinalRiskRisk AssessmentRisk FactorsRuralSamplingSilverSingaporeSiteSmokingSoftware ToolsSolutionsSpecialistStagingSystemTelemedicineTestingTimeTrainingValidationVeinsVisionWeightbasecardiovascular disorder riskcommercializationcostexperienceimprovedinnovationinsightpublic health relevanceretina blood vessel structurescreeningtoolvascular abnormality
项目摘要
DESCRIPTION (provided by applicant): In the US, there are 720,000 annual incidences of heart attack, out of which 515,000 are first time heart attacks. Risk factors for cardiovascular disease (CVD) are thought to be well-defined, but they do not identify all at-risk individuals. Therefore, there is a need to detect other factors that provide more near-term risk assessment for CVD. The early manifestations of risk factors found in the retina can detect a threat of an impending cardiovascular event, and monitoring these precursors provides an early insight into risk of CVD. For this reason, we have developed the "Comprehensive Assessment of Retinal Vasculature" (CARV), a fully automated screening device for the detection of retinal abnormalities and assessment of associated CVD risk. In Phase I, the research team at Vision Quest Biomedical demonstrated the feasibility of the CARV second reader system to provide objective measurements and detect potential vascular abnormalities to assist a retinal reader, resulting in increased disease detection at a reduced reading time. In Phase II, the second reader system will evolve into a fully automatic first reader system that quantifies the risk of CVD based on retinal abnormalities. We will accomplish this through two specific aims. In the first aim, we will add additional methods for detecting retinal abnormalities and lesions. We will then develop a classifier to automatically assign a CVD risk of low, moderate, or severe to each case CARV processes. In the second aim, we will combine these software tools to produce a near real-time system to automatically detect signs of hypertensive retinopathy and assign a CVD risk grade based on the results. At the end of Phase II, we will demonstrate a validated CARV first reader and second reader system. CARV second reader will likely be given a Class I device by the FDA, and we expect clearance within a year. The intended use will be that of an aid to readers in a telemedicine environment. With CARV second reader serving as a predicate device, the CARV first reader system can be submitted as a 510k device to the FDA, following the successful completion of a clinical trial.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Vinayak S Joshi其他文献
Vinayak S Joshi的其他文献
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{{ truncateString('Vinayak S Joshi', 18)}}的其他基金
Automated system to improve compliance to diabetic retinopathy screening
自动化系统可提高糖尿病视网膜病变筛查的依从性
- 批准号:
10697609 - 财政年份:2023
- 资助金额:
$ 68.93万 - 项目类别:
Malarial retinopathy screening system for improved diagnosis of cerebral malaria
疟疾视网膜病变筛查系统可改善脑型疟疾的诊断
- 批准号:
10401912 - 财政年份:2021
- 资助金额:
$ 68.93万 - 项目类别:
Malarial retinopathy screening system for improved diagnosis of cerebral malaria
疟疾视网膜病变筛查系统可改善脑型疟疾的诊断
- 批准号:
10253474 - 财政年份:2021
- 资助金额:
$ 68.93万 - 项目类别:
Comprehensive Assessment of Retinal Vasculature (CARV)
视网膜血管系统综合评估(CARV)
- 批准号:
8644662 - 财政年份:2014
- 资助金额:
$ 68.93万 - 项目类别:
Comprehensive Assessment of Retinal Vasculature (CARV)
视网膜血管系统综合评估(CARV)
- 批准号:
9146953 - 财政年份:2014
- 资助金额:
$ 68.93万 - 项目类别:
Malarial Retinopathy Screening System for Improved Diagnosis of Cerebral Malaria
疟疾视网膜病变筛查系统可改善脑型疟疾的诊断
- 批准号:
8714453 - 财政年份:2014
- 资助金额:
$ 68.93万 - 项目类别:
Malarial Retinopathy Screening System for Improved Diagnosis of Cerebral Malaria
疟疾视网膜病变筛查系统可改善脑型疟疾的诊断
- 批准号:
8850325 - 财政年份:2014
- 资助金额:
$ 68.93万 - 项目类别:
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