Novel 3T MRI of TMJ Using Short and Ultrashort Echo Time (UTE) Techniques

使用短回波时间和超短回波时间 (UTE) 技术的新型 TMJ 3T MRI

• 批准号: 8628663
• 负责人: CHRISTINE B CHUNG
• 金额: $ 55.9万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-03 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8628663
• 关键词: Address; Anatomy; Arthralgia; Biochemical; Biochemistry; Biological Assay; Biological Markers; Biomechanics; Classification; Clinical; Clinical assessments; Collagen; Complex; Data; Digestion; Elements; Evaluation; Face; Fiber; Fibrocartilages; General Population; Glycosaminoglycans; Head and neck structure; Histologic; Histopathology; Hybrids; Hydroxyproline; Imaging Techniques; Imaging problem; In Vitro; Joints; Magnetic Resonance Imaging; Mechanics; Methods; Modeling; Muscle; Musculoskeletal; Musculoskeletal Pain; Orthopedics; Pain; Pathology; Patients; Pattern; Physiologic pulse; Polarization Microscopy; Preparation; Property; Proteoglycan; Protons; Randomized; Relaxation; Resolution; Signal Transduction; Source; Staining method; Stains; Structure; Structure of articular disc of temporomandibular joint; System; Techniques; Temporomandibular Joint; Temporomandibular Joint Disorders; Time; Tissues; Trypsin; Weight; base; biopsychosocial; bone; collagenase; density; design; dimethylmethylene blue; disability; in vivo; innovation; interest; millisecond; novel; prospective; rho; soft tissue; volunteer

DESCRIPTION (provided by applicant): Temporomandibular disorders (TMDs) represent the second most commonly occurring musculoskeletal condition resulting in pain and disability, combining orthopedic principles with biopsychosocial models of pain. The TMJ has complex anatomy comprised largely of fibrocartilaginous components that on MRI are characterized as short T2 tissues (intrinsic MR property). Clinical Imaging Problem and Background: Standard clinical MRI sequences portray these tissues as signal void (black), making them difficult to visually characterize and to quantitatively evaluate. We have implemented high resolution short TE sequences and developed a new 3D UTE technique that was designed to optimally characterize the TMJ tissues. We have also developed novel quantitative MR sequences that combine UTE technique (to allow signal acquisition from TMJ disc, fibrocartilage, condylar subchondral bone) with T2 and T1 rho applications. The UTE T2 prep sequence is a hybrid quantitative MR technique designed to accurately evaluate short T2 values (reflecting collagen orientation and integrity) in the 2 to 10 msec range (as in TMJ tissues determined by our preliminary studies). The UTE T1 rho sequence is a quantitative MR technique that was designed to evaluate proteoglycan integrity in short T2 tissues. Hypothesis: We hypothesize that our prospective, randomized study will show that our novel 3T short TE and UTE MRI techniques tailored for short T2 tissue evaluation of TMJ condylar fibrocartilage and disc, compared to existing techniques tailored for long T2 tissues, will 1) provide more accurate morphologic and structural data including bony changes when evaluated qualitatively in vitro, 2) serve as more sensitive biomarkers of biochemical and biomechanical alterations, as well as degeneration, when evaluated quantitatively in vitro, and 3) offer stronger qualitative and quantitative correlates to in vivo clinical assessment scores. We propose to address this through 3 aims. In the first, we will compare the accuracy of morphologic MR grading based on high resolution 2D short TE and newly developed 3D UTE techniques to those tailored for long T2 tissues. In the second, we will compare sensitivity of quantitative MR properties determined from UTE MRI techniques (short T2 and T1rho values) to those obtained from techniques tailored for long T2 tissues (long T2 and T1rho values) to biochemical and biomechanical alterations, as well as histopathology. In the third we will implement novel 3T UTE MRI high resolution morphologic, 3D UTE, and quantitative UTE MR sequences (2D T2*, UTE T2 Prep and UTE T1 rho) sequences in asymptomatic volunteers and symptomatic patients and correlate findings with a clinical assessment scoring system. Innovation: Our study is innovative in that it uses newly developed MR pulse sequences that propose both morphologic and biochemical evaluation of tissue, and presents new concepts regarding tailoring MRI parameters to specific tissues, and exploring quantitative MR techniques as a biomarker for tissue function.

描述(申请人提供)：颞下颌关节紊乱病(TMD)是导致疼痛和残疾的第二种最常见的肌肉骨骼疾病，它结合了骨科原理和疼痛的生物心理社会模型。TMJ具有复杂的解剖结构，主要由纤维软骨成分组成，在MRI上表现为短T2组织(固有的MR特性)。临床影像问题和背景：标准的临床MRI序列将这些组织描绘为信号空洞(黑色)，这使得它们难以直观地表征和定量评估。我们已经实现了高分辨率短TE序列，并开发了一种新的3D UTE技术，旨在优化TMJ组织的特征。我们还开发了新的定量MR序列，将UTE技术(允许从TMJ盘、纤维软骨、髁突软骨下骨获取信号)与T2和T1 Rho应用相结合。UTE T2 PREP序列是一种混合定量磁共振技术，旨在准确评估2到10毫秒范围内(如我们初步研究确定的TMJ组织)的短T2值(反映胶原的取向和完整性)。UTE T1 Rho序列是一种定量磁共振技术，旨在评估短T2组织中蛋白多糖的完整性。假设：我们假设，我们的前瞻性随机研究将显示，与现有的针对长T2组织的技术相比，我们专为TMJ短T2组织评估的新型3T Short TE和UTE MRI技术将1)在体外进行定性评估时提供更准确的形态和结构数据，包括骨骼变化，2)当在体外进行定量评估时，作为生化和生物力学改变以及退变的更敏感的生物标记物，以及3)提供更强的定性和定量与体内临床评估评分的相关性。我们建议通过三个目标来解决这个问题。首先，我们将比较基于高分辨率2D短TE和新开发的3D UTE技术的形态MR分级的准确性，以及为长T2组织量身定做的那些。在第二项研究中，我们将比较UTE MRI技术(短T2和T1RHO值)和为长T2组织量身定做的技术(长T2和T1RHO值)所确定的定量MR特性对生化和生物力学改变以及组织病理学的敏感性。在第三项研究中，我们将在无症状志愿者和有症状患者中实施新的3T UTE MRI高分辨率形态、3D UTE和定量UTE MR序列(2D T2*、UTE T2 Prep和UTE T1 Rho)序列，并将结果与临床评估评分系统相关联。创新：我们的研究具有创新性，因为它使用了新开发的MR脉冲序列，提出了对组织的形态和生化评估，并提出了关于针对特定组织定制MRI参数的新概念，并探索了定量MR技术作为组织功能的生物标记物。