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Joint Imaging Core of the MARC

MARC 联合成像核心

基本信息

批准号：
10254251
负责人：
CHRISTINE B CHUNG
金额：
$ 16.45万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10254251
关键词：
3-Dimensional Adipose tissue Algorithms Animals Arthritis Basic Science Biochemical Biological Markers Biology Biomedical Engineering Biopsy Bone Marrow Cartilage Clinical Clinical Investigator Clinical Research Collagen Color Communities Coupled Data Data Set Development Devices Diagnosis Diffusion Magnetic Resonance Imaging Engineering Evaluation Fibrosis Functional Imaging Goals Human Human Resources Image Imaging technology Ionizing radiation Joints Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Maps Meniscus structure of joint Metabolism Microscopy Morphology Muscle Muscle Fibers Musculoskeletal Musculoskeletal Diseases Nature Orthopedics Pathology Phosphorus Positioning Attribute Production Proteoglycan Protocols documentation Radiology Specialty Reproducibility Research Research Personnel Resolution Resources Rheumatism Rheumatology Science Services Specimen Structural Biochemistry Structure Synovial Membrane Techniques Technology Time Tissue Sample Tissues Training animal imaging base biomarker development bone clinical phenotype data acquisition experience experimental study follow-up human imaging imaging study implementation barriers in vivo in vivo imaging innovation joint loading multidisciplinary muscle metabolism novel therapeutic intervention pre-clinical radio frequency radiologist structured data tool transcriptomics translational study

项目摘要

JOINT IMAGING CORE ABSTRACT The objective of the Joint Imaging (JI) Core of the Microenvironment in Arthritis Resource Center (MARC) is to facilitate research in the San Diego community focused on the biology of the joint through magnetic resonance imaging (MRI). The JI Core will provide a non-invasive means to image in vivo tissue structure, metabolism, and function of human and small animal joints. The Core's technologies can also provide structured data that can be analyzed and integrated with other datasets, such as transcriptomics from biopsies on the same joint and clinical phenotype. The Core offers a unique integration of radiology and rheumatology that is uncommon among Rheumatic Diseases Research Resource-based Centers, particularly when combined with the computational support from other MARC resources. The non-invasive nature of MRI, coupled with the absence of ionizing radiation and the ability to evaluate all musculoskeletal tissues, renders this resource highly valuable for joint pathology projects and for translational studies aimed at development of biomarkers or novel therapeutic approaches. The Aims of the JI Core are 1) to provide investigators with MR imaging protocols that offer non-invasive morphologic, biochemical and functional evaluation of musculoskeletal tissues, 2) to provide investigators with MR engineering support to include MR compatible devices and radiofrequency (RF) coil development for in vivo, tissue specimen or animal imaging, and 3) to assist investigators with imaging data post-processing algorithms that allow desired expression of data. The Core will also facilitate interactions of pre-clinical investigators with established rheumatology and orthopaedics clinical research resources and with affiliated services if non-MRI small animal imaging is needed. The JI Core will act as catalyzer of multi- disciplinary and innovative science that and bring human imaging technology to basic science investigators.

关节成像核心摘要关节炎资源中心（MARC）微环境联合成像（JI）核心的目标是促进圣地亚哥社区的研究，重点是通过磁共振研究关节的生物学成像（MRI）。JI Core将提供一种非侵入性手段，用于对体内组织结构、代谢以及人类和小动物关节的功能。Core的技术还可以提供结构化数据，可以与其他数据集进行分析和整合，例如来自同一关节活检的转录组学和临床表型。核心提供了一个独特的放射学和风湿病学的整合，这是罕见的在风湿病研究资源为基础的中心，特别是当结合其他MARC资源的计算支持。MRI的非侵入性，加上缺乏电离辐射和评估所有肌肉骨骼组织的能力，使这一资源高度对于联合病理学项目和旨在开发生物标志物或新的治疗方法。JI核心的目的是：1）为研究者提供MR成像方案，提供肌肉骨骼组织的非侵入性形态学、生物化学和功能评估，2）提供 MR工程支持的研究者，包括MR兼容器械和射频（RF）线圈开发体内、组织标本或动物成像，以及3）协助研究者获得成像数据后处理算法，允许所需的数据表达。该核心还将促进以下方面的互动：临床前研究者，具有已建立的风湿病学和骨科临床研究资源，如果需要非MRI小动物成像，则提供附属服务。联合执行核心将作为多方面的催化剂，这是一门学科和创新科学，它将人类成像技术带给基础科学研究人员。