Development and Translation of Novel UTE-MuSIC MR Sequence to Image Around Metal

新型 UTE-MuSIC MR 序列的开发和转化为金属周围的图像

• 批准号: 8594503
• 负责人: CHRISTINE B CHUNG
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8594503
• 关键词: Aging; Area; Arthroplasty; Biochemical; Biological Assay; Characteristics; Chromium; Clinical; Clinical Research; Cobalt; Collagen; Collection; Complication; Degenerative polyarthritis; Development; Diagnosis; Diagnostic; Disease; Eligibility Determination; Evaluation; Failure; Grant; Hip Prosthesis; Hip region structure; Histologic; Image; Imagery; Implant; In Vitro; Injury; Ions; Joints; Liquid substance; Magnetic Resonance; Magnetic Resonance Imaging; Metals; Methods; Modeling; Morphologic artifacts; Motion; Musculoskeletal; Musculoskeletal System; Needles; Orthopedics; Pathogenesis; Pathologic; Pathology; Patient Care; Patients; Pelvis; Physiologic pulse; Population; Predisposition; Prosthesis; Protons; Publishing; Recruitment Activity; Reference Standards; Research; Sepharose; Serum; Signal Transduction; Simulate; Site; Solutions; Structure; System; Techniques; Tendon structure; Testing; Time; Tissues; Translations; Veterans; Visit; cohort; collagenase; improved; in vivo; insight; magnetic field; novel; public health relevance; reconstruction; soft tissue; standard of care

DESCRIPTION (provided by applicant): The aim of the study is to develop and implement novel MR sequences that decrease metallic susceptibility artifact about orthopedic hardware, specifically, total hip arthroplasties (THA). TH metal distorts magnetic field and leads to areas in MR images that are black, and obscure underlying tissue. Other areas appear bright (signal pile up), and are difficult to distinguish fro pathology. In Aim 1, we develop a novel pulse sequence that decreases metallic artifact and allows signal acquisition from short T2 tissues (those black on all clinical MR images). They are black because protons relax before the MR can switch from transmit (proton excitation), to receive (signal collection). Short T2 tissue signal can be accessed with a pulse sequence allowing near immediate signal acquisition after proton excitation (Ultrashort echo time (UTE) MRI). We developed UTE-MSI (Ultrashort Echo Time - Multi-spectral Imaging) with a single published article describing it. It uses a 3D acquisition to allow multiplanar reconstruction, a technique called Multi-spectral imaging to decrease metal artifact, and UTE to visualize short T2 tissues. This sequence suffers from long imaging time. In aim 1, we further develop UTE-MSI sequence, optimize it for improved suppression of metal artifact, better contrast and use a technique called compressed sensing to decrease imaging times. This sequence is UTE-MuSIC (Ultrashort Time to Echo - Multi-Spectral Imaging with Compressed Sensing). Also in aim 1, we compare UTE-MuSIC to a clinical sequence and a well-accepted research sequence (limited distribution to test sites only) that decrease metal artifact. This allows evalution of UTE-MuSIC as compared to standard of care, and best case scenario in research setting. We have developed both qualitative and quantitative methods to compare sequences and will do so in phantoms with metal. In Aim 2, UTE-MuSIC will be compared to clinical and research sequences to quantitatively evaluate fluid collections with varying concentrations of metal ion using techniques from Aim 1. If successful, fluid collections with metal ion could be identified non-invasively. A well-described complication of Metal-on-Metal (MoM) THA is pseudotumor development that contains metal ions and is destructive to soft tissues (tendon). Also in Aim 2, we will compare the ability of UTE-MuSIC sequence to characterize normal and pathologic tendon in phantoms with metal, simulating potential tendon damage in vivo in the setting of pseudotumor. In Aim 3, MRI of patients with MoM THA will be done. The San Diego VA Department of Orthopedics sees 30 to 50 MoM patients/year. Patients will be screened for MR eligibility (standard practice), and patients being followed for MoM THA (n=30) will be recruited for longitudinal MR studies in years 2-4 of the grant. In the MoM cohort, at yearly visits, serum ion levels will be checked. In the presence of peri-prosthetic fluid collections, fluid analysis wil be performed. If revision arthroplasty is indicated from a clinical standpoint, joint tissue and prostheses will be evaluated. Tissue will undergo histological evaluation and grading.

描述(由申请人提供)： 该研究的目的是开发和实施新的MR序列，以减少矫形外科硬件，特别是全髋关节置换术(THA)中的金属易感性伪影。这种金属会扭曲磁场，导致磁共振图像中出现黑色区域，并遮挡住下面的组织。其他区域呈明亮(信号堆积)，很难与病理相鉴别。在目标1中，我们开发了一种新的脉冲序列，它减少了金属伪影，并允许从短T2组织(所有临床MR图像上的黑色组织)获取信号。它们是黑色的，因为质子在MR可以从发射(质子激发)切换到接收(信号采集)之前松弛。短T2组织信号可以通过允许在质子激发(超短回波时间(UTE)MRI)后近乎立即获取信号的脉冲序列来访问。我们开发了UTE-MSI(超短回波时间-多光谱成像)，只发表了一篇文章来描述它。它使用3D采集来进行多平面重建，这是一种被称为多光谱成像的技术，以减少金属伪影，并对短T2组织进行可视化。该序列存在成像时间长的问题。在目标1中，我们进一步开发UTE-MSI序列，对其进行优化以提高对金属伪影的抑制、更好的对比度，并使用一种称为压缩传感的技术来减少成像时间。这个序列是UTE-MUSIC(超短回波时间-压缩传感多光谱成像)。同样在目标1中，我们将UTE-MUSIC与临床序列和广泛接受的研究序列(仅限于测试地点)进行比较，以减少金属伪影。这允许与护理标准和研究环境中的最佳案例情景相比较来评估UTE-MUSIC。我们已经开发了定性和定量的方法来比较序列，并将在模体中与金属进行比较。在目标2中，UTE-MUSIC将与临床和研究序列进行比较，以使用目标1的技术对不同浓度的金属离子液体收集进行定量评估。如果成功，可以非侵入性地识别含有金属离子的液体收集。金属对金属(MOM)全髋关节置换术的一个常见并发症是含有金属离子的假瘤发展，对软组织(肌腱)具有破坏性。同样在目标2中，我们将比较UTE-MUSIC序列对正常和病理肌腱在模体和金属中的表征能力，模拟假瘤背景下体内潜在的肌腱损伤。在目标3中，将对MOMA-THA患者进行MRI检查。圣地亚哥退伍军人事务部整形外科每年接待30到50名母亲患者。将对患者进行MR资格筛查(标准做法)，并将在拨款的2-4年内招募30名接受MOM THA的患者进行纵向MR研究。在母亲队列中，在每年的访问中，将检查血清离子水平。在存在假体周围液体收集的情况下，将进行液体分析。如果从临床的角度来看，翻修关节成形术是必要的，那么将对关节组织和假体进行评估。组织将接受组织学评估和分级。