Development and Translation of Novel UTE-MuSIC MR Sequence to Image Around Metal

新型 UTE-MuSIC MR 序列的开发和转化为金属周围的图像

• 批准号: 8594503
• 负责人: CHRISTINE B CHUNG
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8594503
• 关键词: Aging; Area; Arthroplasty; Biochemical; Biological Assay; Characteristics; Chromium; Clinical; Clinical Research; Cobalt; Collagen; Collection; Complication; Degenerative polyarthritis; Development; Diagnosis; Diagnostic; Disease; Eligibility Determination; Evaluation; Failure; Grant; Hip Prosthesis; Hip region structure; Histologic; Image; Imagery; Implant; In Vitro; Injury; Ions; Joints; Liquid substance; Magnetic Resonance; Magnetic Resonance Imaging; Metals; Methods; Modeling; Morphologic artifacts; Motion; Musculoskeletal; Musculoskeletal System; Needles; Orthopedics; Pathogenesis; Pathologic; Pathology; Patient Care; Patients; Pelvis; Physiologic pulse; Population; Predisposition; Prosthesis; Protons; Publishing; Recruitment Activity; Reference Standards; Research; Sepharose; Serum; Signal Transduction; Simulate; Site; Solutions; Structure; System; Techniques; Tendon structure; Testing; Time; Tissues; Translations; Veterans; Visit; cohort; collagenase; improved; in vivo; insight; magnetic field; novel; public health relevance; reconstruction; soft tissue; standard of care

DESCRIPTION (provided by applicant): The aim of the study is to develop and implement novel MR sequences that decrease metallic susceptibility artifact about orthopedic hardware, specifically, total hip arthroplasties (THA). TH metal distorts magnetic field and leads to areas in MR images that are black, and obscure underlying tissue. Other areas appear bright (signal pile up), and are difficult to distinguish fro pathology. In Aim 1, we develop a novel pulse sequence that decreases metallic artifact and allows signal acquisition from short T2 tissues (those black on all clinical MR images). They are black because protons relax before the MR can switch from transmit (proton excitation), to receive (signal collection). Short T2 tissue signal can be accessed with a pulse sequence allowing near immediate signal acquisition after proton excitation (Ultrashort echo time (UTE) MRI). We developed UTE-MSI (Ultrashort Echo Time - Multi-spectral Imaging) with a single published article describing it. It uses a 3D acquisition to allow multiplanar reconstruction, a technique called Multi-spectral imaging to decrease metal artifact, and UTE to visualize short T2 tissues. This sequence suffers from long imaging time. In aim 1, we further develop UTE-MSI sequence, optimize it for improved suppression of metal artifact, better contrast and use a technique called compressed sensing to decrease imaging times. This sequence is UTE-MuSIC (Ultrashort Time to Echo - Multi-Spectral Imaging with Compressed Sensing). Also in aim 1, we compare UTE-MuSIC to a clinical sequence and a well-accepted research sequence (limited distribution to test sites only) that decrease metal artifact. This allows evalution of UTE-MuSIC as compared to standard of care, and best case scenario in research setting. We have developed both qualitative and quantitative methods to compare sequences and will do so in phantoms with metal. In Aim 2, UTE-MuSIC will be compared to clinical and research sequences to quantitatively evaluate fluid collections with varying concentrations of metal ion using techniques from Aim 1. If successful, fluid collections with metal ion could be identified non-invasively. A well-described complication of Metal-on-Metal (MoM) THA is pseudotumor development that contains metal ions and is destructive to soft tissues (tendon). Also in Aim 2, we will compare the ability of UTE-MuSIC sequence to characterize normal and pathologic tendon in phantoms with metal, simulating potential tendon damage in vivo in the setting of pseudotumor. In Aim 3, MRI of patients with MoM THA will be done. The San Diego VA Department of Orthopedics sees 30 to 50 MoM patients/year. Patients will be screened for MR eligibility (standard practice), and patients being followed for MoM THA (n=30) will be recruited for longitudinal MR studies in years 2-4 of the grant. In the MoM cohort, at yearly visits, serum ion levels will be checked. In the presence of peri-prosthetic fluid collections, fluid analysis wil be performed. If revision arthroplasty is indicated from a clinical standpoint, joint tissue and prostheses will be evaluated. Tissue will undergo histological evaluation and grading.

描述（由申请人提供）： 该研究的目的是开发和实施新型的MR序列，以减少有关骨科硬件的金属敏感性伪像，特别是总髋关节置换术（THA）。金属会扭曲磁场，并导致MR图像中黑色的区域，并掩盖了潜在的组织。其他区域显得明亮（信号堆积），并且很难区分出来的病理学。 在AIM 1中，我们开发了一种新型的脉冲序列，可减少金属伪像，并允许从短T2组织（所有临床MR图像上的黑色）中获取信号。它们是黑色的，因为质子在MR可以从传输（质子激发）转换为接收（信号收集）之前放松。可以使用脉冲序列访问短T2组织信号，允许质子激发后接近立即获得信号（Ultrashort Echo Time（UTE）MRI）。我们开发了UTE-MSI（Ultrashort Echo Time - 多光谱成像），其中一篇已发表的文章描述了它。它使用3D采集来允许多平台重建，该技术称为多光谱成像以减少金属伪像，并可视化短T2组织。该序列遭受了较长的成像时间。在AIM 1中，我们进一步开发了UTE-MSI序列，优化它以改善金属伪影的抑制，更好的对比度并使用一种称为压缩传感的技术来减少成像时间。该序列是ute-music（超时的时间回声 - 带有压缩感应的多光谱成像）。同样在AIM 1中，我们将Ute-Music与临床序列和良好接受的研究序列（仅对测试位点的分布限制）进行了比较，从而减少了金属伪像。与护理标准和研究环境中的最佳案例相比，这允许评估UTE音乐。我们已经开发了定性和定量方法来比较序列，并将在金属的幻象中进行。 在AIM 2中，将使用AIM 1的技术进行定量评估金属离子的液体收集的临床和研究序列。如果成功，可以非侵入性地鉴定出具有金属离子的液体。金属对金属（MOM）THA的描述良好的并发症是伪云的发育，其中包含金属离子，对软组织具有破坏性（肌腱）。同样在AIM 2中，我们将比较UTE-Music序列表征具有金属幻像中正常和病理肌腱的能力，从而在假肿瘤的情况下模拟体内潜在的肌腱损伤。 在AIM 3中，将完成妈妈THA患者的MRI。弗吉尼亚州圣地亚哥骨科部门看到30至50名妈妈/年患者。将筛选患者的MR资格（标准实践），并将在授予2 - 4年内招募妈妈THA（n = 30）的患者进行纵向MR研究。在妈妈队列中，每年拜访时，将检查血清离子水平。在存在周围液体液体收集的情况下，将进行液体分析。如果从临床角度表明修订性关节置换术，则将评估关节组织和假体。组织将接受组织学评估和分级。