Joint Imaging Core of the MARC

联合成像岩芯摘要 关节炎资源中心(MARC)微环境联合成像(JI)核心的目标是 促进圣地亚哥社区通过磁共振重点研究关节生物学 成像(MRI)。JI Core将提供一种非侵入性手段来成像体内的组织结构、新陈代谢、 以及人体和小动物关节的功能。核心的技术还可以提供结构化数据， 可以分析并与其他数据集集成，例如同一关节活检的转录本 和临床表型。核心提供独特的放射学和风湿学的结合，这是不常见的 在风湿病研究资源中心中，特别是与 来自其他MARC资源的计算支持。磁共振成像的非侵入性，加上缺乏 电离辐射和评估所有肌肉骨骼组织的能力，使这一资源具有很高的 对联合病理学项目和旨在开发生物标记物或新奇生物的翻译研究有价值 治疗方法。JI Core的目标是1)为调查人员提供磁共振成像方案， 提供肌肉骨骼组织的非侵入性形态、生化和功能评估，2)提供 具有MR工程支持的调查人员将包括MR兼容设备和射频(RF)线圈 开发活体、组织标本或动物成像，以及3)协助研究人员处理成像数据 允许所需数据表达的后处理算法。核心还将促进以下各项的互动 拥有风湿学和骨科临床研究资源的临床前研究人员 如果需要非核磁共振小动物成像，则提供附属服务。JI Core将作为多项技术的催化剂 学科和创新科学，并将人类成像技术带给基础科学研究人员。

JOINT IMAGING CORE ABSTRACT The objective of the Joint Imaging (JI) Core of the Microenvironment in Arthritis Resource Center (MARC) is to facilitate research in the San Diego community focused on the biology of the joint through magnetic resonance imaging (MRI). The JI Core will provide a non-invasive means to image in vivo tissue structure, metabolism, and function of human and small animal joints. The Core's technologies can also provide structured data that can be analyzed and integrated with other datasets, such as transcriptomics from biopsies on the same joint and clinical phenotype. The Core offers a unique integration of radiology and rheumatology that is uncommon among Rheumatic Diseases Research Resource-based Centers, particularly when combined with the computational support from other MARC resources. The non-invasive nature of MRI, coupled with the absence of ionizing radiation and the ability to evaluate all musculoskeletal tissues, renders this resource highly valuable for joint pathology projects and for translational studies aimed at development of biomarkers or novel therapeutic approaches. The Aims of the JI Core are 1) to provide investigators with MR imaging protocols that offer non-invasive morphologic, biochemical and functional evaluation of musculoskeletal tissues, 2) to provide investigators with MR engineering support to include MR compatible devices and radiofrequency (RF) coil development for in vivo, tissue specimen or animal imaging, and 3) to assist investigators with imaging data post-processing algorithms that allow desired expression of data. The Core will also facilitate interactions of pre-clinical investigators with established rheumatology and orthopaedics clinical research resources and with affiliated services if non-MRI small animal imaging is needed. The JI Core will act as catalyzer of multi- disciplinary and innovative science that and bring human imaging technology to basic science investigators.