Integrating optical coherence tomography with laryngeal high-speed videoendoscopy

光学相干断层扫描与喉高速视频内窥镜集成

• 批准号: 8647260
• 负责人: NICUSOR IFTIMIA
• 金额: $ 22.5万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8647260
• 关键词: Address; Anatomy; Animals; Anterior; Appearance; Clinical; Collaborations; Data; Data Analyses; Devices; Dimensions; Disease; Endoscopes; Engineering; Ensure; Epithelial; Evaluation; General Hospitals; Government; Human; Image; Imagery; Imaging technology; Lamina Propria; Laryngoscopes; Larynx; Lateral; Light; Massachusetts; Measures; Modality; Modeling; Monitor; Motion; Operative Surgical Procedures; Optical Coherence Tomography; Optics; Otolaryngology; Patients; Performance; Persons; Phase; Phonation; Preclinical Testing; Production; Property; Qualifying; Research; Resolution; Rest; Scanning; Scientist; Shapes; Slice; Source; Specimen; Speed; Structure; Superficial Lesion; Surface; System; Technology; Testing; Time; Tissues; Treatment outcome; Validation; Voice; Voice Disorders; base; design; improved; in vivo; instrument; kinematics; multidisciplinary; operation; physical science; programs; prototype; public health relevance; research study; signal processing; success; vibration; vocal cord

DESCRIPTION (provided by applicant): There is a growing clinical need for improving the assessment of vocal fold tissue properties in vivo, especially dynamic properties measured during human voice production. To address this need, Physical Sciences Inc. (PSI), in collaboration with MGH Voice Center, will develop a clinically-viable imaging system that will integrate optical coherence tomography (OCT) with laryngeal high-speed videoendoscopy (HSV). A transoral endoscope will be developed to assess surface appearance, surface shape, and sub-epithelial anatomy of vocal fold tissue at rest and during phonation. Phase I bench-top testing on fresh calf larynges will include empirical validation of spatial and temporal alignment and optimization of the field of view for each modality. The PSI/MGH team will perform data analysis and assessment of the results to continue to develop effective ways of visualizing the vocal folds using the different modes of system operation. A clinical prototype is proposed to be developed in Phase II and tested on human patients.

描述（由申请人提供）：临床上越来越需要改进体内声带组织特性的评估，特别是在人类发声过程中测量的动态特性。为了满足这一需求，物理科学公司。(PSI)与MGH语音中心合作，将开发一种临床可行的成像系统，该系统将光学相干断层扫描（OCT）与喉部高速视频内窥镜（HSV）相结合。将开发一种经口内窥镜，以评估声带组织在休息和发声期间的表面外观、表面形状和上皮下解剖结构。新鲜小牛喉的第一阶段实验室测试将包括空间和时间对齐的经验验证以及每种模式的视野优化。PSI/MGH团队将对结果进行数据分析和评估，以继续开发使用不同系统操作模式可视化声带的有效方法。临床原型拟在第二阶段开发，并在人类患者身上进行测试。