Electrohydraulic impactor for peripheral arterial occlusion management

用于外周动脉闭塞治疗的电动液压冲击器

基本信息

  • 批准号:
    10256269
  • 负责人:
  • 金额:
    $ 26.31万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-04-01 至 2024-03-31
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract The primary goal of this research project is to develop and pre-clinically validate a novel electrohydraulic impact (EHI) device that will aid clinicians in treating patients with peripheral artery chronic total occlusions (CTOs). CTOs represent the complete blockage of the blood vessels and are difficult to recanalize using traditional percutaneous transluminal angioplasty (PTA) techniques and apparatus. The presence of calcifications and fibrotic tissues within CTOs, together with the vessel size and tortuosity, are the causes of multiple complications during treatment. Therefore, a significant number of CTOs are treated using an invasive bypass surgery, which has significant morbidity and requires extensive recovery time. The central challenge to catheter based nonsurgical percutaneous CTO treatment is that it often is incredibly difficult to cross the calcified and resistant chronic blockage with an angioplasty wire. Although efforts have been made to use excimer lasers or rotational atherectomy devices (rotablator), these plaque modification devices require a wire to cross the CTO, which limits their utility if no wire crossing is established. To address this clinically important problem of difficult CTO crossing, Physical Sciences Inc. (PSI) in collaboration with Brigham and Women's Hospital (BWH) and Impact Vascular (IVAS) proposes to develop and pre-clinically evaluate a novel and safer method and device for CTO management. The proposed device uses an electrohydraulic impactor that creates a directed impact pressure of several hundred bar to penetrate the CTO plaque without damaging normal elastic arterial tissue. Therefore, EHI will facilitate CTO crossing and distal guide-wire passage to enable definitive treatment with balloons and stents.
项目总结/摘要 本研究项目的主要目标是开发和临床前验证一种新型的电动液压 冲击(EHI)器械,将帮助临床医生治疗外周动脉慢性完全闭塞患者 (CTO)。CTO代表血管的完全阻塞,并且难以使用血管造影剂再通。 传统的经皮腔内血管成形术(PTA)技术和设备。的存在 CTO内的钙化和纤维化组织以及血管尺寸和迂曲度是导致 治疗过程中出现多种并发症。因此,大量的CTO使用侵入性治疗。 旁路手术,其具有显著的发病率并且需要长时间的恢复。核心挑战是 基于导管的非手术经皮CTO治疗的另一个问题是, 钙化和抗血管成形术线的慢性阻塞。尽管已经努力利用 准分子激光或旋转斑块切除术设备(旋转消融器),这些斑块修饰设备需要电线 穿过CTO,如果没有建立导线交叉,则限制了它们的实用性。为了解决这个临床上重要的 CTO穿越困难的问题,Physical Sciences Inc. (PSI)与布里格姆和妇女组织合作, Hospital(BWH)和Impact Vascular(IVAS)提议开发一种新型且更安全的 一种CTO管理的方法和装置。所提出的装置使用电动液压冲击器, 几百巴的定向冲击压力穿透CTO斑块而不损坏正常弹性 动脉组织因此,EHI将有助于CTO通过和远端导丝通过, 用球囊和支架治疗。

项目成果

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NICUSOR IFTIMIA其他文献

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{{ truncateString('NICUSOR IFTIMIA', 18)}}的其他基金

Smart sensor for guiding safe delivery of anesthetic and pain drugs through epidurals
智能传感器用于指导通过硬膜外麻醉剂和止痛药物的安全输送
  • 批准号:
    10883933
  • 财政年份:
    2022
  • 资助金额:
    $ 26.31万
  • 项目类别:
Intelligent Optical Probe for Guiding Core Needle Biopsy Procedures
用于引导核心针活检程序的智能光学探头
  • 批准号:
    10481578
  • 财政年份:
    2022
  • 资助金额:
    $ 26.31万
  • 项目类别:
Smart sensor for guiding safe delivery of anesthetic and pain drugs through epidurals
智能传感器用于指导通过硬膜外麻醉剂和止痛药物的安全输送
  • 批准号:
    10545953
  • 财政年份:
    2022
  • 资助金额:
    $ 26.31万
  • 项目类别:
Intelligent Optical Probe for Guiding Core Needle Biopsy Procedures
用于引导核心针活检程序的智能光学探头
  • 批准号:
    10625956
  • 财政年份:
    2022
  • 资助金额:
    $ 26.31万
  • 项目类别:
Optical probe for in situ assessment of pulmonary fibrosis
用于肺纤维化原位评估的光学探头
  • 批准号:
    9907714
  • 财政年份:
    2020
  • 资助金额:
    $ 26.31万
  • 项目类别:
Endoscopic Multifunctional Optical Coherence Tomography for Airway Tissue Injury Management
用于气道组织损伤管理的内窥镜多功能光学相干断层扫描
  • 批准号:
    10081106
  • 财政年份:
    2020
  • 资助金额:
    $ 26.31万
  • 项目类别:
Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance
用于皮肤癌检测和治疗指导的多模态光学探头
  • 批准号:
    10206472
  • 财政年份:
    2019
  • 资助金额:
    $ 26.31万
  • 项目类别:
Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance
用于皮肤癌检测和治疗指导的多模态光学探头
  • 批准号:
    10224140
  • 财政年份:
    2019
  • 资助金额:
    $ 26.31万
  • 项目类别:
IGF::OT::IGF: SBIR PHASE II, TOPIC 331: OPTICAL BIOSENSOR FOR REAL-TIME ASSESSMENT OF TUMOR CELLULARITY DURING CORE NEEDLE BIOPSY PROCEDURES.
IGF::OT::IGF:SBIR 第二阶段,主题 331:用于在芯针活检过程中实时评估肿瘤细胞性的光学生物传感器。
  • 批准号:
    9360347
  • 财政年份:
    2016
  • 资助金额:
    $ 26.31万
  • 项目类别:
Integrating optical coherence tomography with laryngeal high-speed videoendoscopy
光学相干断层扫描与喉高速视频内窥镜集成
  • 批准号:
    8647260
  • 财政年份:
    2014
  • 资助金额:
    $ 26.31万
  • 项目类别:

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