Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance

用于皮肤癌检测和治疗指导的多模态光学探头

• 批准号: 10206472
• 负责人: NICUSOR IFTIMIA
• 金额: $ 67.22万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-18 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10206472
• 关键词: 3-Dimensional; Ablation; Adoption; Aftercare; Agreement; Area; Biological; Biopsy; Caliber; Cancer Detection; Cicatrix; Clinic; Clinical; Coagulation Process; Cold Therapy; Collaborations; Complement; Confocal Microscopy; Curettage procedure; Dermis; Dermoscopy; Diagnosis; Diagnostic Imaging; Dose; Early Diagnosis; Emotional; Engineering; Evaluation; Excision; Feedback; Frequencies; Goals; Health Care Costs; Histology; Image; Image Enhancement; Imaging Device; Imaging Techniques; Imaging technology; Incidence; Lasers; Lateral; Lesion; Magnetic Resonance Imaging; Malignant Neoplasms; Measurement; Measures; Memorial Sloan-Kettering Cancer Center; Methods; Mohs Surgery; Morphology; Mosaicism; Multimodal Imaging; Older Population; Operative Surgical Procedures; Optical Coherence Tomography; Optics; PUVA Photochemotherapy; Patient Care; Patients; Pharmacotherapy; Phase; Physicians; Prevalence; Radiation; Radiation therapy; Recovery; Recurrence; Research Project Grants; Residual Tumors; Resolution; Risk; Screening for Skin Cancer; Selection for Treatments; Skin; Skin Cancer; Skin Carcinoma; Source; Specificity; Specimen; Speed; System; Technology; Time; Tissues; Translating; Trauma; Trauma patient; Triage; Tumor Subtype; Ultrasonography; Validation; Visit; Visual; aging population; base; cancer diagnosis; cancer subtypes; cancer therapy; commercialization; cost; design; dosage; effective therapy; healing; imaging capabilities; imaging probe; improved; instrument; microscopic imaging; multidisciplinary; multimodality; non-invasive monitor; novel; optical imaging; patient population; physical science; programs; prototype; psychological trauma; reconstruction; side effect; submicron; success; targeted treatment; tool; treatment planning; tumor; tv watching

Project Summary/Abstract The primary goal of this research project is to develop and translate to clinical use a novel optical imaging technology based on combined Optical Coherence Tomography (OCT) and Confocal Microscopy (CM) for non- invasive real-time diagnosis of non-melanoma skin cancers (NMSCs), tumor subtyping and margin mapping that will assist physician-patient decision in treatment planning (biopsy vs. no biopsy, surgery vs. non-surgical), as well as on performing the therapy. The increasing incidence and prevalence in skin cancer, especially among the aging population, combined with the high costs of surgery and subsequent reconstruction, and the physical and psychological trauma that patient endures with surgical intervention, has led to an increasing adoption and implementation of alternative non-surgical treatments that can be highly effective and less invasive. Laser ablation and radiotherapy have been proven to be effective therapies for common skin cancers and have the additional benefits that are easily tolerable and not associated with less scarring or disfigurement. Therefore, their clinical use has substantially increased within the recent years to treat skin cancers. However, the primary challenge in delivering effective laser fluence or radiotherapy dose for skin cancer is accurate delineation of the cancer target, both in depth and laterally. Fortunately, the unique capability of OCT/CM to visualize tissue morphology with micron-scale resolution can be used in real-time in the clinics to aid therapy target delineation and enable more precise delivery of therapy without need to “estimate” the subclinical extent of spread, thereby minimizing side effects. In addition, CM/OCT can be used to confirm eradication of skin cancer, which is currently limited to visual inspection, a highly insensitive and subjective method. The preliminary evaluation of the feasibility of this technology for aiding accurate target delineation will be performed during the Phase I program. Based on Phase I conclusions, the technology will be refined in Phase II and evaluated clinically on a large pool of patient population. Both therapy decision aiding and therapy guidance capabilities will be evaluated.

项目摘要/摘要 该研究项目的主要目标是开发并转化为临床使用一种新型的光学成像 基于非光学相干断层扫描（OCT）和共聚焦显微镜（CM）的技术 非黑色素瘤皮肤癌（NMSC）的侵入性实时诊断，肿瘤亚型和边缘映射 这将有助于治疗计划中的身体健康决定（活检与无活检，手术与非手术）， 以及进行疗法。 皮肤癌的发病率和患病率增加，尤其是在老龄化的人群中，合并 凭借高昂的手术成本以及随后的重建以及身体和心理创伤 患者通过手术干预持久，导致了越来越多的采用和实施 非手术治疗可能是非常有效且侵入性较小的非手术治疗方法。激光消融和放射疗法具有 事实证明，他是常见皮肤癌的有效疗法，并具有额外的好处 可以容忍的，并且与较少的疤痕或毁容无关。因此，它们的临床使用大大 近年来治疗皮肤癌的增加。但是，提供有效的主要挑战 激光通量或放射治疗剂量用于皮肤癌是癌症靶标的准确描述 并横向。幸运的是，OCT/cm的独特能力可以通过微米尺度可视化组织形态 分辨率可以在诊所实时使用，以帮助治疗目标划分，并使更精确 无需“估计”接种范围的疗法的交付，从而最大程度地减少了副作用。 此外，CM/OCT可用于确认根除皮肤癌，目前仅限于视觉 检查，一种高度不敏感和主观的方法。 对这项技术对有助于准确目标描述的可行性的初步评估将是 在第一阶段计划中执行。根据第一阶段的结论，该技术将在 第二阶段并在大量患者人群上进行临床评估。两种疗法的决定和治疗 将评估指导能力。