Seizure focus delineation using spontaneous and stimulus evoked EEG features

 描述(由申请人提供)：使用自发和刺激诱发脑电特征描绘癫痫灶摘要全球估计有5000万人患有癫痫。在这些人中，预计约30%的人尽管接受了最大限度的药物治疗，但仍有癫痫发作。如果引起癫痫发作的大脑区域被完全限制，这些患者的癫痫发作可以通过适当的手术干预得到控制。在前期工作的基础上，本研究将致力于三个研究目标：(A)利用简单的神经活动记录、复杂的信号处理技术和先进的决策算法来描绘难治性癫痫患者的致痫区域；(B)检查不同大脑的刺激反应特征 区域和(C)转向非侵入性方法，包括利用上述方法的高密度头皮脑电和经颅磁刺激。拟议中的项目的另一个主要目标是让卡什博士能够在成功的指导记录的基础上，建立一个指导计划，以满足正在为以患者为导向的研究生涯做准备的住院医生和神经学研究员的需求。该提案这一方面的主要目的是：(A)加强现有的个人辅导能力；(B)创造基于团体的职业发展经验；(C)扩大住院医师和研究员在翻译神经科学方面获得辅导和基础研究经验的能力。这些目标最终旨在极大地提高高素质、有动力的初级调查人员实现独立并开始富有成效的以患者为导向的研究生涯的能力。

 DESCRIPTION (provided by applicant): Seizure focus delineation using spontaneous and stimulus evoked EEG features Abstract an estimated 50 million people worldwide suffer from epilepsy. Of these, it is expected that ~30% continue to have seizures despite maximal medical therapy. The seizures of these patients may be controlled through appropriate surgical intervention if the region of brain giving rise to seizure activity is full circumscribed. Buildingon preliminary work, this study will pursue three research aims focused on (a) using brief recordings of neural activity, sophisticated signal processing techniques and advanced decision algorithms to delineate the epileptogenic region in patients with intractable epilepsy; augment this procedure with (b) examinations of the stimulation-response characteristics of different brain regions and (c) move toward non-invasive methodologies including high-density scalp EEG and transcranial magnetic stimulation that leverage the above approaches. The other major goal of the proposed project is to allow Dr. Cash to build on a successful record of mentoring and build a mentoring program tailored to the needs of residents and fellows in neurology who are preparing for a career in patient oriented research. The primary aims of this aspect of the proposal are to (a) bolster existing individual mentoring capabilities, (b) create group based career development experiences and (c) broaden the ability of residents and fellows to obtain mentoring and foundational research experiences in translational neuroscience. These goals ultimately are intended to greatly improve the ability of highly qualified, motived junior investigators to reach independence and begin productive patient-oriented research careers.